Ligand meso-tartrate

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Basic Ligand Information

Molecular Structure
Picture of meso-tartrate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C4H6O6
meso-tartrate
FEWJPZIEWOKRBE-XIXRPRMCSA-N
Synonyms:
(2R,3S)-dihydroxysuccinic acid, (2R,3S)-tartaric acid, (2R,3S)-tartrate, (2S,3R)-tartrate, (R,S)-tartrate, 2R,3S-tartrate, m-tartrate, meso-Tartarate, meso-tartaric acid, meso-tartrate(S,R), mesotartaric acid, mesotartrate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
meso-tartrate + NAD+ = dihydroxyfumaric acid + NADH
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
trans-2,3-epoxysuccinate + H2O = meso-tartrate
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (14 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
meso-tartrate + NAD+ = ? + NADH
show the reaction diagram
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(2S,3R)-tartrate + NAD(P)+ = ? + NAD(P)H + H+
show the reaction diagram
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meso-tartrate + NAD+ = oxaloglycolate + NADH + H+
show the reaction diagram
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meso-tartrate + acceptor = 2-oxo-3-hydroxybutanoate + reduced acceptor
show the reaction diagram
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meso-tartrate = D-glycerate + CO2
show the reaction diagram
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(R,S)-Tartrate = Oxaloacetate + H2O
show the reaction diagram
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meso-tartrate = ?
show the reaction diagram
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(2R,3S)-Tartrate = (2R,3R)-Tartrate
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
dihydroxyfumaric acid + NADH = meso-tartrate + NAD+
show the reaction diagram
-
-

Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activation in presence of excess carbamoyl phosphate and limiting L-aspartate
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Inhibitor in Enzyme-catalyzed Reactions (27 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive inhibitor
-
competitive
-
10 mM, 14% inhibition
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Ki: 3.15 mM
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competitive
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2.5 mM, 31% inhibition
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3D Structure of Enzyme-Ligand-Complex (PDB) (227 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (3 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.617
-
-

KM Value (8 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

Ki Value (11 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.7
-
inhibition of catalytic subunits, C3
10
-
pH 6.0, 25°C
3.15
-
-
0.66
-
pH 8.0, 37°C

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
8.71
-
pH 8.3, 37°C

References & Links

Links to other databases for meso-tartrate

ChEBI
PubChem
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PubChem