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Ligand L-arginine hydroxamate

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Substrate (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.5.3.6

L-arginine hydroxamate + H2O = ?

711003

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6.3.2.B16

ATP + L-Val + L-Arg-NHOH = ADP + phosphate + L-Val-L-Arg-NHOH + L-Val-L-Val-L-Arg-NHOH

702768

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Inhibitor in Enzyme-catalyzed Reactions (7 results)

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Show Inhibitors (7 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

3.4.11.22

competitive

650310

-

3.4.24.69

-

683671

2g7q, 3D-view

3.4.24.69

-

683671

2imb, 3D-view

3.4.24.69

binding site and complex structure, overview

683349

2g7q, 3D-view

3.4.24.69

binding site and complex structure, overview

683349

2imb, 3D-view

3.4.24.69

4 entries

3.5.1.104

-

752784

-

6.1.1.19

-

257

-

3D Structure of Enzyme-Ligand-Complex (PDB) (8 results)

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Show 3D Structure of Enzyme-Ligand-Complex (PDB) (8 entries)

EC NUMBER

ENZYME 3D STRUCTURE

3.4.24.69

2g7q, 3D-view

3.4.24.69

2imb, 3D-view

3.4.24.69

2g7q, 3D-view

3.4.24.69

2imb, 3D-view

3.4.24.69

2g7q, 3D-view

3.4.24.69

2imb, 3D-view

3.4.24.69

2g7q, 3D-view

3.4.24.69

2imb, 3D-view

3.4.24.69

8 entries

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (1 result)

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Show Turnover Number (1 entry)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

3.5.3.6

0.15

-

in 50 mM CHES/HCl, pH 9.5 containing 10 mM dithiothreitol, at 37°C

711003

K_M Value (1 result)

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Show KM Value (1 entry)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

3.5.3.6

6.9

-

in 50 mM CHES/HCl, pH 9.5 containing 10 mM dithiothreitol, at 37°C

711003

K_i Value (1 result)

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Show KI Value (1 entry)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

3.4.11.22

0.6

-

pH 7.8, 30°C

650310

IC₅₀ Value (1 result)

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Show IC50 Value (1 entry)

EC NUMBER

IC50 VALUE

IC50 VALUE MAXIMUM

COMMENTARY

LITERATURE

3.4.24.69

0.06

-

-

683349

References & Links

Literature References (7)

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Show Reference (7 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

257

6337851

Arginyl-tRNA synthetase from brewer's yeast. Purification, properties, and steady-state mechanism

1983

Thiebe, R.

Eur. J. Biochem.

130

517-524

650310

10862968

The role of amino acid residues in the active site of a midgut microvillar aminopeptidase from the beetle Tenebrio molitor

2000

Cristofoletti, P.T.; Terra, W.R.

Biochim. Biophys. Acta

1479

185-195

683349

17524984

Structures of Clostridium botulinum neurotoxin serotype A light chain complexed with small-molecule inhibitors highlight active-site flexibility

2007

Silvaggi, N.R.; Boldt, G.E.; Hixon, M.S.; Kennedy, J.P.; Tzipori, S.; Janda, K.D.; Allen, K.N.

Chem. Biol.

14

533-542

683671

17244603

Mechanism of substrate recognition by botulinum neurotoxin serotype A

2007

Chen, S.; Kim, J.J.; Barbieri, J.T.

J. Biol. Chem.

282

9621-9627

702768

20057135

A novel L-amino acid ligase from Bacillus subtilis NBRC3134 catalyzed oligopeptide synthesis

2010

Kino, K.; Arai, T.; Tateiwa, D.

Biosci. Biotechnol. Biochem.

74

129-134

711003

19545534

Expression of peptidylarginine deiminase from Porphyromonas gingivalis in Escherichia coli: enzyme purification and characterization

2009

Rodriguez, S.B.; Stitt, B.L.; Ash, D.E.

Arch. Biochem. Biophys.

488

14-22

752784

29257674

Structures of the peptidoglycan N-acetylglucosamine deacetylase Bc1974 and its complexes with zinc metalloenzyme inhibitors

2018

Giastas, P.; Andreou, A.; Papakyriakou, A.; Koutsioulis, D.; Balomenou, S.; Tzartos, S.J.; Bouriotis, V.; Eliopoulos, E.E.

Biochemistry

57

753-763

Links to other databases for L-arginine hydroxamate

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Show Links (1 entry)

ChEBI

PubChem