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Ligand isovitexin

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Natural Substrate (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.1.106

UDP-glucose + isovitexin = UDP + isovitexin 2''-O-beta-D-glucoside

488401

-

Substrate in Enzyme-catalyzed Reactions (3 results)

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Show Substrate (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.3.50

isovitexin + O2 = 3'-keto-isovitexin + H2O2

765689

-

2.4.1.106

UDP-glucose + isovitexin = UDP + isovitexin 2''-O-beta-D-glucoside

488401, 488403

-

2.4.1.170

UDP-glucose + isovitexin = UDP + isovitexin 7-O-beta-D-glucoside

488803

-

Product in Enzyme-catalyzed Reactions (3 results)

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Show Product (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.1.360

UDP-alpha-D-glucose + 2-hydroxynaringenin = UDP + isovitexin + H2O

0

-

2.4.1.360

UDP-D-galactose + 2-hydroxynaringenin = UDP + isovitexin

0

-

2.4.1.360

UDP-xylose + 2-hydroxynaringenin = UDP + isovitexin

0

-

2.4.1.360

3 entries

Inhibitor in Enzyme-catalyzed Reactions (4 results)

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Show Inhibitors (4 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.213

-

697265

-

3.4.24.24

interacts with enzyme residues Glu121, Leu83, Ala84, Pro140, Ile141, His120, Ala136, Leu116, Ala139, and Leu137, binding structure analysis, and modelling, overview

754869

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3.4.24.34

interacts with enzyme residues Val112, Ser218, Leu119, Glu118, Asn226, Ser225, Thr224, Asn184, Phe192, and Asp115, binding structure analysis, and modelling, overview

754869

-

3.4.24.35

interacts with enzyme residues Glu241, Ala242, Pro255, Pro254, Thr251, Leu222, Tyr248, Arg241, Met247, His226, and Glu227, binding structure analysis, and modeling, overview

754869

-

Enzyme Kinetic Parameters

K_M Value (1 result)

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Show KM Value (1 entry)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.4.1.106

0.09

-

-

488401, 488403

References & Links

Literature References (6)

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Show Reference (6 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

488401

-

The 2'æ-O-glucosylation of vitexin and isovitexin in petals of Silene alba is catalysed by two different enzymes

1980

Heinsbroek, R.; van Brederode, J.; van Nigtevecht, G.; Maas, J.; Kamsteeg, J.; Besson, E.; Chopin, J.

Phytochemistry

19

1935-1937

488403

-

The pH dependent substrate specificity of UDP-fglucose:isovitexin 2'æ-O-glucosyltransferase

1979

Van Brederode, J.; Chopin, J.; Kamsteeg, J.; van Nigtevecht, G.; Heinsbroek, R.

Phytochemistry

18

655-656

488803

8370455

Purification of an UDP-glucose:flavone, 7-O-glucosyltransferase, from Silene latifolia using a specific interaction between the enzyme and phenyl-Sepharose

1993

Vellekoop, P.; Lugones, L.; van Brederode, J.

FEBS Lett.

330

36-40

697265

19007764

AKR1C3 as a potential target for the inhibitory effect of dietary flavonoids

2009

Skarydova, L.; Zivna, L.; Xiong, G.; Maser, E.; Wsol, V.

Chem. Biol. Interact.

178

138-144

754869

29394875

Enzymatic inhibitory activity of Ficus deltoidea leaf extract on matrix metalloproteinase-2, 8 and 9

2019

Abu Bakar, A.R.; Ripen, A.M.; Merican, A.F.; Mohamad, S.B.

Nat. Prod. Res.

33

1765-1768

765689

34583991

FAD-dependent C-glycoside-metabolizing enzymes in microorganisms Screening, characterization, and crystal structure analysis

2021

Kumano, T.; Hori, S.; Watanabe, S.; Terashita, Y.; Yu, H.Y.; Hashimoto, Y.; Senda, T.; Senda, M.; Kobayashi, M.

Proc. Natl. Acad. Sci. USA

118

e2106580118

Links to other databases for isovitexin

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Show Links (1 entry)

ChEBI

PubChem