Ligand Cys-Gly

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Basic Ligand Information

Molecular Structure
Picture of Cys-Gly (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C5H10N2O3S
Cys-Gly
ZUKPVRWZDMRIEO-VKHMYHEASA-N
Synonyms:
cysteinylglycine, L-Cys-Gly, L-cysteinyl-glycine, L-cysteinylglycine


Show all pahtways known for Show all BRENDA pathways known for Cys-Gly

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
Cys-Gly + H2O = Cys + Gly
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = 2-oxoglutarate + L-cysteinylglycine
show the reaction diagram
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glutathione = L-cysteinylglycine + 5-oxo-L-proline
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (15 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
Cys-Gly + H2O = Cys + Gly
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (27 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
Pro-Thr-Val-Thr-Gly-Cys-S-S-Cys-Gly + NADPH + H+ = Pro-Thr-Val-Thr-Gly-Cys + Cys-Gly + NADP+
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Gly-L-Cys-Gly + H2O = Gly + L-Cys-Gly
show the reaction diagram
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N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = 2-oxoglutarate + L-cysteinylglycine
show the reaction diagram
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gamma-Glu-Cys-Gly = L-glutamate + Cys-Gly
show the reaction diagram
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glutathione = L-cysteinylglycine + 5-oxo-L-proline
show the reaction diagram
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glutathione = 5-oxoproline + L-Cys-Gly
show the reaction diagram
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ATP + L-cysteine + glycine = ADP + phosphate + L-cysteinyl-glycine
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Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activates
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Inhibitor in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
inhibits the activity of the Zn2+-Zn2+-enzyme with substrate Leu-Gly competitively
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substrate inhibition
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5 mM, 20% inhibition
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (11 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
10700
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pH 7.5, 37°C

KM Value (11 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
2.5
-
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7.8
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pH 7.5, 37°C
1.51
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Ki Value (3 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.041
-
pH 7.4, 38°C
0.0164
-
Mn2+-Zn2+-enzyme, versus substrate Leu-Gly
0.025
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pH 7.0, 37°C

References & Links

Links to other databases for Cys-Gly

ChEBI
PubChem
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PubChem