Ligand coenzyme Q10

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Basic Ligand Information

Molecular Structure
Picture of coenzyme Q10 (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C59H90O4
coenzyme Q10
ACTIUHUUMQJHFO-UPTCCGCDSA-N
Synonyms:
2-(all-trans-decaprenyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione, co-enzyme Q, coenzyme Q, coenzyme Q-10, CoQ, oxidized coenzyme Q, reduced coenzyme Q10, ubiquinone-50, ubiquinone 50

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + co-enzyme Q = 1-(beta-D-ribofuranosyl)nicotinamide + reduced co-enzyme Q
show the reaction diagram
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(S)-dihydroorotate + coenzyme Q = orotate + reduced coenzyme Q
show the reaction diagram
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trans-4-hydroxy-L-proline + coenzyme Q10 = (3R,5S)-3-hydroxy-1-pyrroline-5-carboxylate + ?
show the reaction diagram
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sulfide + coenzyme Q = sulfane sulfur + reduced coenzyme Q
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
sn-glycerol 3-phosphate + coenzyme Q10 = glycerone phosphate + reduced coenzyme Q10
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (27 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + co-enzyme Q = 1-(beta-D-ribofuranosyl)nicotinamide + reduced co-enzyme Q
show the reaction diagram
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L-dihydroorotate + CoQ = orotate + ?
show the reaction diagram
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trans-4-hydroxy-L-proline + coenzyme Q10 = (3R,5S)-3-hydroxy-1-pyrroline-5-carboxylate + ?
show the reaction diagram
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NADPH + H+ + coenzyme Q10 = NADP+ + reduced coenzyme Q10
show the reaction diagram
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coenzyme Q10 + NAD(P)H = reduced coenzyme Q10 + NAD(P)+
show the reaction diagram
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NADPH + H+ + 2 coenzyme Q10 = NADP+ + ?
show the reaction diagram
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coenzyme Q-10 + NADPH = ubiquinol + NADP+
show the reaction diagram
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NADH + coenzyme Q10 = ?
show the reaction diagram
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NADH + coenzyme Q10 = ?
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
sn-glycerol 3-phosphate + coenzyme Q10 = glycerone phosphate + reduced coenzyme Q10
show the reaction diagram
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NADPH + H+ + coenzyme Q10 = NADP+ + reduced coenzyme Q10
show the reaction diagram
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coenzyme Q10 + NAD(P)H = reduced coenzyme Q10 + NAD(P)+
show the reaction diagram
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sulfide + coenzyme Q10 = sulfur + reduced coenzyme Q10
show the reaction diagram
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hydrogen sulfide + glutathione + coenzyme Q10 = S-sulfanylglutathione + reduced coenzyme Q10
show the reaction diagram
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S-adenosyl-L-methionine + 2-(all-trans-decaprenyl)-5-hydroxy-6-methoxy-3-methylcyclohexa-2,5-diene-1,4-dione = S-adenosyl-L-homocysteine + 2-(all-trans-decaprenyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione
show the reaction diagram
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Enzyme Cofactor/Cosubstrate (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
primary electron acceptor in vivo
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CoQ, an essential component participating in the electron transfer from enzyme HDH to cytochrome bc1 complex. HDH activity can be recovered with exogenous CoQ addition
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Activator in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
primary electron acceptor in vivo
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CoQ, activates
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Inhibitor in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

3D Structure of Enzyme-Ligand-Complex (PDB) (41 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (5 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
61
-
pH 8.0, 30°C
5
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pH 8.0, 25°C, recombinant His-tagged enzyme
5
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pH 7.5, 10°C

KM Value (11 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.05
-
-
0.0119
-
pH 8.0, 25°C, recombinant His-tagged enzyme
0.0119
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pH 7.5, 10°C
0.297
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References & Links

Links to other databases for coenzyme Q10

ChEBI
PubChem
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PubChem