Ligand beta-thujaplicin

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Basic Ligand Information

Molecular Structure
Picture of beta-thujaplicin (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C10H12O2
beta-thujaplicin
FUWUEFKEXZQKKA-UHFFFAOYSA-N
Synonyms:
2-hydroxy-4-(1-methylethyl)-2,4,6-cycloheptatrien-1-one, hinokitiol

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
UDPglucose + beta-thujaplicin = UDP + beta-thujaplicin beta-D-monoglucoside
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (11 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
best inhibitors are tropolone, hinokitiol and hexestrol
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70-100% inhibition at 0.2 mM
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the cleavage of the cellular eukaryotic translation initiation factor eIF4GI by 2A protease is abolished in the presence of hinokitiol, no significant amounts of eIF4GI cleavage products are found within 24 h of infection
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Enzyme Kinetic Parameters

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.00056
-
pH 7.4, 25°C, recombinant enzyme
0.5
-
-

IC50 Value (10 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.05
-
above, pH 7.4, 25°C, recombinant enzyme

References & Links

Links to other databases for beta-thujaplicin

ChEBI
PubChem
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PubChem