Ligand duroquinone

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Basic Ligand Information

Molecular Structure
Picture of duroquinone (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C10H12O2
duroquinone
WAMKWBHYPYBEJY-UHFFFAOYSA-N
Synonyms:
1,4-tetramethylbenzoquinone, 2,3,5,6-tetramethyl-1,4-benzoquinone, 2,3,5,6-tetramethyl-p-benzoquinone, tetramethyl-1,4-benzoquinone, tetramethyl-4-benzoquinone, tetramethyl-p-benzoquinone

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
methane + duroquinol + O2 = methanol + duroquinone + H2O
show the reaction diagram
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methane + duroquinol + O2 = methanol + duroquinone + H2O
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (35 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
duroquinone + NADPH = ?
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duroquinone + NADPH = ?
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duroquinone + NADPH + H+ = duroquinol + NADP+
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sn-glycerol 3-phosphate + duroquinone = glycerone phosphate + duroquinol
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(S)-malate + duroquinone = oxaloacetate + duroquinol
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tetramethyl-4-benzoquinone + reduced coenzyme F420 = tetramethyl-1,4-benzoquinol + oxidized coenzyme F420
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H2O + duroquinone + hv = O2 + duroquinol
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phenylacetyl-CoA + H2O + duroquinone = phenylglyoxylyl-CoA + duroquinol
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tetramethyl-1,4-benzoquinone + NADP+ = ? + NADPH + H+
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succinate + duroquinone = fumarate + duroquinol
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15-cis-phytoene + duroquinone = 9,15,9'-tricis-zeta-carotene + duroquinol
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reduced electron-transferring-flavoprotein + duroquinone = electron-transferring-flavoprotein + duroquinol
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trans-4-hydroxy-L-proline + duroquinone = (3R,5S)-3-hydroxy-1-pyrroline-5-carboxylate + duroquinol
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N6-(2-isopentenyl)adenine + duroquinone = ?
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NADH + H+ + duroquinone = NAD+ + duroquinol
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tetramethyl-1,4-benzoquinone + NADPH = ?
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sulfide + duroquinone = sulfur + duroquinol
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Product in Enzyme-catalyzed Reactions (30 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
duroquinol + O2 = duroquinone + H2O
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methane + duroquinol + O2 = methanol + duroquinone + H2O
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NH3 + duroquinol + O2 = NH2OH + duroquinone + H2O
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duroquinol + O2 + H+/in = duroquinone + H2O + H+/out
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duroquinol + O2 = duroquinone + H2O
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duroquinol + plastocyanin = duroquinone + reduced plastocyanin
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2 duroquinol + O2 + 4 H+[side 1] = 2 duroquinone + 2 H2O + 4 H+[side 2]
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tetramethyl-p-benzoquinol + cytochrome c = tetramethyl-p-benzoquinone + reduced cytochrome c
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Activator in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
reduction of 2,6-dichlorophenol indophenol by solubilized enzyme is activated significantly by addition of the quinones decylubiquinone, duroquinone, 2-methyl-1,4-naphthoquinone (vitamin K3), ubiquinone-0 and ubiquinone-1. Optimal activation is observed with ubiquinone-1
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stimulates NQO1 activity
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activates
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Inhibitor in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
noncompetitive inhibitor
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3D Structure of Enzyme-Ligand-Complex (PDB) (14 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (10 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
2.167
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with 2,6-dichlorophenolindophenol, pH 7.6, 30°C
18.1
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recombinant enzyme, pH 7.4, 25°C
0.27
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at pH 7.5 and 25°C
0.3
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pH 7.0, 0.1 M potassium phosphate, 1 mM EDTA, 25°C

KM Value (9 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0195
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recombinant enzyme, pH 7.4, 25°C
0.143
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at pH 7.5 and 25°C
0.489
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Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

References & Links

Links to other databases for duroquinone

ChEBI
PubChem
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PubChem