Ligand C14:0-ceramide
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information
Molecular Structure

C32H63NO3
C14:0-ceramide
ZKRPGPZHULJLKJ-JHRQRACZSA-N
D-erythro-C14:0 ceramide, D-eythro-C14:0 ceramide, N-(myristoyl)-sphingoid base, N-myristoylsphingosine
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
C14:0-ceramide + H2O = myristate + sphingosine
-
Substrate in Enzyme-catalyzed Reactions (3 results)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
D-erythro-C14:0 ceramide + ATP = D-erythro-C14:0 ceramide 1-phosphate + ADP
-
ATP + D-eythro-C14:0 ceramide = ADP + D-eythro-C14:0 ceramide 1-phosphate
-
C14:0-ceramide + H2O = myristate + sphingosine
-
Product in Enzyme-catalyzed Reactions (3 results)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
sphingosine + myristoyl-CoA = N-myristoylsphingosine + CoA
-
myristoyl-CoA + a sphingoid base = N-(myristoyl)-sphingoid base + CoA
-
myristic acid + sphingosine = N-myristoylsphingosine + H2O
-
Enzyme Kinetic Parameters
KM Value (1 result)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
References & Links
Literature References (3)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Substrate specificity of human ceramide kinase
2005
Wijesinghe, D.S.; Massiello, A.; Subramanian, P.; Szulc, Z.; Bielawska, A.; Chalfant, C.E.
J. Lipid Res.
46
2706-2716
Ceramide kinase and ceramide-1-phosphate
2007
Wijesinghe, D.S.; Lamour, N.F.; Gomez-Munoz, A.; Chalfant, C.E.
Methods Enzymol.
434
265-292
Substrate specificity, membrane topology, and activity regulation of human alkaline ceramidase 2 (ACER2)
2010
Sun, W.; Jin, J.; Xu, R.; Hu, W.; Szulc, Z.M.; Bielawski, J.; Obeid, L.M.; Mao, C.
J. Biol. Chem.
285
8995-9007
Links to other databases for C14:0-ceramide