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Ligand 5-Aminopentanamide

Basic Ligand Information

Molecular Structure

Show all BRENDA pathways known for 5-Aminopentanamide

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Natural Substrate (2 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.5.1.30

5-aminopentanamide + H2O = 5-aminopentanoate + NH3

745703, 745704, 754623, 728239, 746458

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3.5.1.30

5-aminopentanamide + H2O = ?

172030, 172031

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3.5.1.30

2 entries

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

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Show Natural Product (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.13.12.2

L-lysine + O2 = 5-aminopentanamide + CO2 + H2O

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Substrate in Enzyme-catalyzed Reactions (3 results)

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Show Substrate (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.4.22.8

benzoyl-Arg ethyl ester + 5-amino-pentanoic acid amide = ethanol + benzoyl-Arg-5-amino-pentanoic acid amide

652992

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3.5.1.30

5-aminopentanamide + H2O = 5-aminopentanoate + NH3

172030, 172031, 745703, 745704, 754623, 728239, 746458

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3.5.1.30

5-aminopentanamide + H2O = ?

172030, 172031

-

3.5.1.30

2 entries

Product in Enzyme-catalyzed Reactions (2 results)

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Show Product (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.13.12.2

L-lysine + O2 = 5-aminopentanamide + CO2 + H2O

, 390102, 440266, 440278

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1.13.12.2

L-lysine + O2 = 5-aminovaleramide + CO2 + H2O

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1.13.12.2

2 entries

Inhibitor in Enzyme-catalyzed Reactions (1 result)

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Show Inhibitors (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.13.12.2

42% inhibition at 5 mM

440273

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Enzyme Kinetic Parameters

K_M Value (1 result)

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Show KM Value (1 entry)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

3.5.1.30

2

-

-

172030

References & Links

Literature References (12)

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Show Reference (12 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

172030

-

delta-Aminovaleramidase (Pseudomonas putida)

1971

Reitz, M.S.; Rodwell, V.W.

Methods Enzymol.

17

158-165

172031

5432799

delta-Aminovaleramidase of Pseudomonas putida

1970

Reitz, M.S.; Rodwell, V.W.

J. Biol. Chem.

245

3091-3096

390102

-

Flavoprotein oxygenases

1974

Flashner, M.S.; Massey, V.

Mol. Mech. Oxygen Activ. (Hayaishi, O., ed.) Academic Press, New York

-

245-283

440266

1165238

A possible involvement of sulfhydryl groups in the conversion of lysine monooxygenase to an oxidase

1975

Yamauchi, T.; Yamamoto, S.; Hayaishi, O.

J. Biol. Chem.

250

7127-7133

440273

4640470

Regulation of a catabolic pathway. Lysine degradation in Pseudomonas putida

1972

Vandecasteele, J.P.; Hermann, M.

Eur. J. Biochem.

31

80-85

440278

5772467

Studies on monooxygenases. I. General properties of crystalline L-lysine monooxygenase

1969

Takeda, H.; Yamamoto, S.; Kojima, Y.; Hayaishi, O.

J. Biol. Chem.

244

2935-2941

652992

10750491

Investigations on the enzyme specificity of clostripain: a new efficient biocatalyst for the synthesis of peptide isosteres

2000

Gunther, R.; Stein, A.; Bordusa, F.

J. Org. Chem.

65

1672-1679

728239

23246520

Metabolic engineering of Escherichia coli for the production of 5-aminovalerate and glutarate as C5 platform chemicals

2013

Park, S.J.; Kim, E.Y.; Noh, W.; Park, H.M.; Oh, Y.H.; Lee, S.H.; Song, B.K.; Jegal, J.; Lee, S.Y.

Metab. Eng.

16

42-47

745703

27618862

Systems metabolic engineering of Corynebacterium glutamicum for the production of the carbon-5 platform chemicals 5-aminovalerate and glutarate

2016

Rohles, C.; Giesselmann, G.; Kohlstedt, M.; Wittmann, C.; Becker, J.

Microb. Cell Fact.

15

154

745704

27717386

Metabolic engineering of Corynebacterium glutamicum for enhanced production of 5-aminovaleric acid

2016

Shin, J.H.; Park, S.H.; Oh, Y.H.; Choi, J.W.; Lee, M.H.; Cho, J.S.; Jeong, K.J.; Joo, J.C.; Yu, J.; Park, S.J.; Lee, S.Y.

Microb. Cell Fact.

15

174

746458

27510748

Overexpression of transport proteins improves the production of 5-aminovalerate from L-lysine in Escherichia coli

2016

Li, Z.; Xu, J.; Jiang, T.; Ge, Y.; Liu, P.; Zhang, M.; Su, Z.; Gao, C.; Ma, C.; Xu, P.

Sci. Rep.

6

30884

754623

30144560

Metabolic engineering of Corynebacterium glutamicum for the production of glutaric acid, a C5 dicarboxylic acid platform chemical

2019

Kim, H.T.; Khang, T.U.; Baritugo, K.A.; Hyun, S.M.; Kang, K.H.; Jung, S.H.; Song, B.K.; Park, K.; Oh, M.K.; Kim, G.B.; Kim, H.U.; Lee, S.Y.; Park, S.J.; Joo, J.C.

Metab. Eng.

51

99-109

Links to other databases for 5-Aminopentanamide

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Show Links (1 entry)

ChEBI

PubChem

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