Ligand L-selenocysteine

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

Basic Ligand Information

Molecular Structure
Picture of L-selenocysteine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C3H7NO2Se
L-selenocysteine
ZKZBPNGNEQAJSX-REOHCLBHSA-N
Synonyms:
selenocysteine


Show all pahtways known for Show all BRENDA pathways known for L-selenocysteine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
O-succinyl-L-homoserine + L-selenocysteine = selenocystathionine + succinate
show the reaction diagram
-
L-selenocysteine + reduced acceptor = selenide + L-alanine + acceptor
show the reaction diagram

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
O-acetyl-L-serine + selenide = L-selenocysteine + acetate
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (17 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
hercynine + L-selenocysteine + O2 = S-(hercyn-2-yl)-L-selenocysteine S-oxide + H2O
show the reaction diagram
-
S-adenosyl-L-methionine + L-selenocysteine = S-adenosyl-L-homocysteine + Se-methyl-L-selenocysteine
show the reaction diagram
-
L-selenocysteine = L-alanine + H2Se
show the reaction diagram
-
ATP + selenocysteine + tRNACys = AMP + diphosphate + selenocysteinyl-tRNACys
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
O-acetyl-L-serine + selenide = L-selenocysteine + acetate
show the reaction diagram
-
-
O-acetyl-Ser + selenide = selenocysteine + acetate
show the reaction diagram
-

Inhibitor in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
0.015 mM, 10% residual activity
-
above 1 mM
-
inhibits desulfuration of L-cysteine
-
-
-

Metals and Ions (12 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
the enzyme contains selenocysteine
-

3D Structure of Enzyme-Ligand-Complex (PDB) (97 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (11 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
1600
-
-
0.357
-
for the L-cysteine desulfurase domain, 2 mM DTT, pH 9.3, 37°C
46
-
pH 9.0, 37°C

KM Value (32 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.62
-
-
0.07
-
-
0.2
-
for the L-cysteine desulfurase domain, 2 mM DTT, pH 9.3, 37°C

References & Links

Links to other databases for L-selenocysteine

ChEBI
PubChem
-
PubChem