Ligand 3-oxoglutarate

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Basic Ligand Information

Molecular Structure
Picture of 3-oxoglutarate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C5H6O5
3-oxoglutarate
ZDFDJJJGIRGMBE-FDKCPYSGSA-N
Synonyms:
3-oxoglutaric acid

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
succinyl-CoA + 3-oxoglutarate = succinate + 3-oxoglutaryl-CoA
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive inhibitor with respect to 2-oxoglutarate, noncompetitive with respect to Fe2+
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27% inhibition at 2.5 mM
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3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.8
-
-
2.8
-
competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate

References & Links

Links to other databases for 3-oxoglutarate

ChEBI
PubChem
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PubChem