Ligand dihydroquercetin

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Basic Ligand Information

Molecular Structure
Picture of dihydroquercetin (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C15H12O7
dihydroquercetin
CKLJMWTZIZZHCS-REOHCLBHSA-N
Synonyms:
(+-)-taxifolin, (+/-)-dihydroquercetin, (+/-)-taxifolin, 2,3-dihydroquercetin, dihydro-3,3',4',5,7-pentahydroxy flavone, guaijaverin, rac-taxifolin

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

In Vivo Product in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
dihydrokaempferol + [reduced NADPH-hemoprotein reductase] + O2 = dihydroquercetin + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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-
dihydrokaempferol + [reduced NADPH-hemoprotein reductase] + O2 = dihydroquercetin + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (24 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
S-adenosyl-L-methionine + dihydroquercetin = S-adenosyl-L-homocysteine + ?
show the reaction diagram
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S-adenosyl-L-methionine + dihydro-3,3',4',5,7-pentahydroxy flavone = S-adenosyl-L-homocysteine + dihydroisorhamnetin
show the reaction diagram
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adenosine 3'-phosphate 5'-phosphosulfate + dihydroquercetin = adenosine 3',5'-bisphosphate + dihydroquercetin 7-sulfate
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
dihydrokaempferol + [reduced NADPH-hemoprotein reductase] + O2 = dihydroquercetin + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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-
dihydrokaempferol + [reduced NADPH-hemoprotein reductase] + O2 = dihydroquercetin + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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-
eriodictyol + 2-oxoglutarate + O2 = dihydroquercetin + luteolin + succinate + CO2 + 2 H2O
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
0.025 mM
-
50% inhibition at 0.041163 mM
-
IC50: 0.08 mM
-
0.1 mM, about 25% inhibition
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i.e. (2R,3R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydro-4H-1-benzopyran-4-one
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (9 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
3.1
-
pH 6.3, temperature not specified in the publication

KM Value (14 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.037
-
pH 7.4
0.435
-
-

IC50 Value (3 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.08
-
IC50: 0.08 mM
0.0195
-
at 37C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogen
0.12
-
pH 6.0, 37C

References & Links

Links to other databases for dihydroquercetin

ChEBI
PubChem
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PubChem