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3-hydroxy-benzo(a)pyrene + UDP-glucuronate = 3-hydroxy-benzo(a)pyrene 3-O-glucuronate + UDP
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3-hydroxy-benzo[a]pyrene + UDP-D-glucose = benzo[a]pyrenil-3-O-D-glucoside + UDP
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3-hydroxybenzo(a)pyrene + UDP-glucuronate = ?
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3-hydroxybenzo[a]pyrene + UDP-glucuronate = UDP + benzo[a]pyren-3-yl-beta-D-glucuronide
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3-hydroxybenzo[a]pyrene + UDPglucuronate = UDP + 3-hydroxybenzo[a]pyrene-O-glucuronide
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3'-phosphoadenylylsulfate + 3-hydroxybenzo[a]pyrene = adenosine 3',5'-bisphosphate + benzo[a]pyrene 3-sulfate
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0.0072
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with UDP-D-xylose, recombinant enzyme in microsomes, pH 7.4, 37°C
0.0075
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with UDP-D-glucose, recombinant enzyme in microsomes, pH 7.4, 37°C
0.271
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wild-type, pH 7.4, 37°C
0.278
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mutant K75R, pH 7.4, 37°C
0.000053
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liver enzyme, pH 7.0, 35°C
0.000069
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intestinal enzyme, pH 7.0, 35°C
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Identification and purification of multiple forms of UDP-glucuronosyltransferase
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Purification of rat-liver microsomal UDP-glucuronyltransferase. Separation of two enzyme forms inducible by 3-methylcholanthrene or phenobarbital
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Purification and characterization of hepatic and intestinal phenol sulfotransferase with high affinity for benzo[a]pyrene phenols from channel catfish, Ictalurus punctatus
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Enzymatic characterization and interspecies difference of phenol sulfotransferases, ST1A forms
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Analysis of substrate specificities and tissue expression of rat UDP-glucuronosyltransferases UGT1A7 and UGT1A8
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Drug Metab. Dispos.
33
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Importance of UDP-glucuronosyltransferase 1A10 (UGT1A10) in the detoxification of polycyclic aromatic hydrocarbons: decreased glucuronidative activity of the UGT1A10139Lys isoform
2006
Dellinger, R.W.; Fang, J.L.; Chen, G.; Weinberg, R.; Lazarus, P.
Drug Metab. Dispos.
34
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Characterization of UDP-glucuronosyltransferase 2A1 (UGT2A1) variants and their potential role in tobacco carcinogenesis
2011
Bushey, R.T.; Chen, G.; Blevins-Primeau, A.S.; Krzeminski, J.; Amin, S.; Lazarus, P.
Pharmacogenet. Genomics
21
55-65
UDP-glycosyltransferase 3A metabolism of polycyclic aromatic hydrocarbons potential importance in aerodigestive tract tissues
2020
Vergara, A.G.; Watson, C.J.W.; Chen, G.; Lazarus, P.
Drug Metab. Dispos.
48
160-168
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