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Ligand 2-tetradecenoyl-CoA

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (3 results)

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Show Substrate (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.3.1.8

2-trans-tetradecenoyl-CoA + NADPH = tetradecanoyl-CoA + NADP+

390753, 390870

-

4.2.1.119

tetradec-2-enoyl-CoA + H2O = ?

33737

-

4.2.1.74

trans-2-tetradecenoyl-CoA + H2O = (3S)-3-hydroxytetradecanoyl-CoA

5869, 5868, 698680

-

Product in Enzyme-catalyzed Reactions (10 results)

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Show Product (10 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.3.3.6

myristoyl-CoA + O2 = trans-2-tetradecenoyl-CoA + H2O2

0

-

1.3.8.7

n-tetradecanoyl-CoA + phenazine methosulfate + 2,6-dichloroindophenol = 2-tetradecenoyl-CoA + reduced acceptor

391203, 391272

-

1.3.8.7

tetradecanoyl-CoA + acceptor = 2-tetradecenoyl-CoA + reduced acceptor

391343, 391201

-

1.3.8.8

myristoyl-CoA + acceptor = 2-tetradecenoyl-CoA + reduced acceptor

0

-

1.3.8.8

tetradecanoyl-CoA + electron-transfer flavoprotein = 2-tetradecenoyl-CoA + reduced electron-transfer flavoprotein

391325, 391371, 391272, 391282, 394650

-

1.3.8.8

tetradecanoyl-CoA + Meldola's Blue = 2-tetradecenoyl-CoA + reduced meldola blue

391275

-

1.3.8.8

tetradecanoyl-CoA + phenazine methosulfate = 2-tetradecenoyl-CoA + reduced phenazine methosulfate

394662, 391047, 391203, 391272, 391282, 394667, 391268

-

1.3.8.8

myristoyl-CoA + acceptor = trans(2)-tetradecenoyl-CoA + reduced acceptor

0

-

5.3.3.8

3-cis-Tetradecenoyl-CoA = 2-trans-Tetradecenoyl-CoA

0, 652357

-

5.3.3.8

3-trans-tetradecenoyl-CoA = 2-trans-tetradecenoyl-CoA

652357

-

1.3.8.7

2 entries

1.3.8.8

5 entries

5.3.3.8

2 entries

Enzyme Kinetic Parameters

K_M Value (3 results)

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Show KM Value (3 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

4.2.1.119

0.005

-

-

33737

4.2.1.74

0.024

-

-

5868

4.2.1.74

0.024

-

25°C

698680

4.2.1.74

2 entries

References & Links

Literature References (20)

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Show Reference (20 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

5868

7278662

Short-chain and long-chain enoyl-CoA hydratases from pig heart muscle

1981

Fong, J.C.; Schulz, H.

Methods Enzymol.

71

390-398

5869

8323290

Purification and characterization of the trifunctional beta-oxidation complex from pig heart mitochondria

1993

Luo, M.J.; He, X.Y.; Sprecher, H.; Schulz, H.

Arch. Biochem. Biophys.

304

266-271

33737

8902629

Purification and properties of human D-3-hydroxyacyl-CoA dehydratase: medium-chain enoyl-CoA hydratase is D-3-hydroxyacyl-CoA dehydratase

1996

Jiang, L.L.; Kobayashi, A.; Matsuura, H.; Fukushima, H.; Hashimoto, T.

J. Biochem.

120

624-632

390753

3977322

Solubilization and purification of hepatic microsomal trans-2-enoyl-CoA reductase: evidence for the existence of a second long-chain enoyl-CoA reductase

1985

Prasad, M.R.; Chiang, C.F.; Cook, L.; Cinti, D.L.

Arch. Biochem. Biophys.

237

535-544

390870

3994691

Purification and characterization of 2-enoyl-CoA-reductase from bovine liver

1985

Cvetanovic, M.; Moreno de la Garza, M.; Dommes, V.; Kunau, W.H.

Biochem. J.

227

49-56

391047

2914148

Compartmentation of dicarboxylic acid beta-oxidation in rat liver: importance of peroxisomes in the metabolism of dicarboxylic acids

1989

Suzuki, H.; Yamada, J.; Watanabe, T.; Suga, T.

Biochim. Biophys. Acta

990

25-30

391201

3597357

Purification and properties of short chain acyl-CoA, medium chain acyl-CoA, and isovaleryl-CoA dehydrogenases from human liver

1987

Finocchiaro, G.; Ito, M.; Tanaka, K.

J. Biol. Chem.

262

7982-7989

391203

6401712

Separation and properties of five distinct acyl-CoA dehydrogenases from rat liver mitochondria. Identification of a new 2-methyl branched chain acyl-CoA dehydrogenase

1983

Ikeda, Y.; Dabrowski, C.; Tanaka, K.

J. Biol. Chem.

258

1066-1076

391268

4084576

Spectroscopic analysis of the interaction of rat liver short-chain, medium-chain, and long-chain acyl coenzyme A dehydrogenases with acyl coenzyme A substrates

1985

Ikeda, Y.; Okamura-Ikeda, K.; Tanaka, K.

Biochemistry

24

7192-7199

391272

3968063

Purification and characterization of short-chain, medium-chain, and long-chain acyl-CoA dehydrogenases from rat liver mitochondria. Isolation of the holo- and apoenzymes and conversion of the apoenzyme to the holoenzyme

1985

Ikeda, Y.; Okamura-Ikeda, K.; Tanaka, K.

J. Biol. Chem.

260

1311-1325

391275

6546382

Purification and properties of acyl coenzyme A dehydrogenases from bovine liver. Formation of 2-trans,4-cis-decadienoyl coenzyme A

1984

Dommes, V.; Kunau, W.H.

J. Biol. Chem.

259

1789-1797

391282

7334008

Purification and properties of rat liver acyl-CoA dehydrogenases and electron transfer flavoprotein

1981

Furuta, S.; Miyazawa, S.; Hashimoto, T.

J. Biochem.

90

1739-1750

391325

-

Fatty acid oxidation in cultured skin fibroblasts from patients with inherited disorders of fatty acid metabolism: studies on the specificity of acyl-CoA dehydrogenases

1987

Chalmers, R.A.; English, N.

Biochem. Soc. Trans.

15

489-491

391343

6139087

Peroxisomal fatty acyl-coenzyme A oxidation in chicken liver

1983

Ishii, H.; Ishii, S.; Kazama, M.; Suga, T.

Arch. Biochem. Biophys.

226

484-491

391371

9182995

Characterization of human and pig kidney long-chain-acyl-CoA dehydrogenases and their role in beta-oxidation

1997

Eder, M.; Krautle, F.; Dong, Y.; Vock, P.; Kieweg, V.; Kim, J.J.; Strauss, A.W.; Ghisla, S.

Eur. J. Biochem.

245

600-607

394650

13319294

On the mechanism of dehydrogenation of fatty acyl derivatives of coenzyme A

1956

Hauge, J.G.; Crane, F.L.; Beinert, H.

J. Biol. Chem.

219

727-733

394662

7769092

Purification of human very-long-chain acyl-coenzyme A dehydrogenase and characterization of its deficiency in seven patients

1995

Aoyama, T.; Souri, M.; Ushikubo, S.; Kamijo, T.; Yamaguchi, S.; Kelley, R.I.; Rhead, W.J.; Uetake, K.; Tanaka, K.; Hashimoto, T.

J. Clin. Invest.

95

2465-2473

394667

10198089

Identification, separation, and characterization of acyl-coenzyme A dehydrogenases involved in mitochondrial beta-oxidation in higher plants

1999

Bode, K.; Hooks, M.A.; Couee, I.

Plant Physiol.

119

1305-1314

652357

11781327

Functional characterization of DELTA3,DELTA2-enoyl-CoA isomerases from rat liver

2002

Zhang, D.; Yu, W.; Geisbrecht, B.V.; Gould, S.J.; Sprecher, H.; Schulz, H.

J. Biol. Chem.

277

9127-9132

698680

4828315

Long chain enoyl coenzyme A hydratase from pig heart

1974

Schulz, H.

J. Biol. Chem.

249

2704-2709

Links to other databases for 2-tetradecenoyl-CoA

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Show Links (1 entry)

ChEBI

PubChem

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