Ligand ceftazidime

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Basic Ligand Information

Molecular Structure
Picture of ceftazidime (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C22H22N6O7S2
ceftazidime
ORFOPKXBNMVMKC-DWVKKRMSSA-N
Synonyms:
(6R,7R,Z)-7-(2-(2-aminothiazol-4-yl)- 2-(2-carboxypropan-2-yloxyimino)acetamido)-8-oxo- 3-(pyridinium-1-ylmethyl)-5-thia-1-aza-bicyclo[4.2.0] oct-2-ene-2-carboxylate, ceftaxidime, ceftazidim

Show all pahtways known for Show all pathways known for ceftazidime

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ceftazidime + H2O = (2R)-2-[(R)-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[[(2-carboxypropan-2-yl)oxy]imino]acetyl]amino](carboxy)methyl]-5-[(pyridin-1-ium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
in vitro inhibition
-
competitive inhibition
-
slight inhibition of purified elastase
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (50 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (56 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
3.59
-
at 25C, pH 8.0

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
2.476
-
at 25C, pH 8.0

References & Links

Links to other databases for ceftazidime

ChEBI
PubChem
ChEBI
PubChem