We're sorry, but BRENDA doesn't work properly without JavaScript. Please make sure you have JavaScript enabled in your browser settings.
Ligand 2-hydroxy-7-methoxy-5-methyl-1-naphthoate Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information
C1 3 H1 2 O4
2-hydroxy-7-methoxy-5-methyl-1-naphthoate
LYGUXQMPYLCEGL-UHFFFAOYSA-N
Related pathways
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP + 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + CoA = AMP + diphosphate + 2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA
-
In Vivo Product in Enzyme-catalyzed Reactions (1 result)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
S-adenosyl-L-methionine + 2,7-dihydroxy-5-methyl-1-naphthoate = S-adenosyl-L-homocysteine + 2-hydroxy-7-methoxy-5-methyl-1-naphthoate
-
-
Substrate in Enzyme-catalyzed Reactions (1 result)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP + 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + CoA = AMP + diphosphate + 2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA
-
Product in Enzyme-catalyzed Reactions (1 result)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
S-adenosyl-L-methionine + 2,7-dihydroxy-5-methyl-1-naphthoate = S-adenosyl-L-homocysteine + 2-hydroxy-7-methoxy-5-methyl-1-naphthoate
-
-
Enzyme Kinetic Parameters
kcat Value (Turnover Number) (2 results)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.63
-
pH and temperature not specified in the publication
KM Value (2 results)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.00059
-
pH and temperature not specified in the publication
References & Links Literature References (1)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Characterization of NcsB2 as a promiscuous naphthoic acid/coenzyme A ligase integral to the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin
2007
Cooke, H.A.; Zhang, J.; Griffin, M.A.; Nonaka, K.; van Lanen, S.G.; Shen, B.; Bruner, S.D.
J. Am. Chem. Soc.
129
7728-7729
Links to other databases for 2-hydroxy-7-methoxy-5-methyl-1-naphthoate