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Ligand alpha-humulene

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Natural Substrate (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.14.113

alpha-humulene + O2 + [reduced NADPH-hemoprotein reductase] = 10-hydroxy-alpha-humulene + [oxidized NADPH-hemoprotein reductase] + H2O

717135, 717593, 717468

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In Vivo Product in Enzyme-catalyzed Reactions (3 results)

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Show Natural Product (3 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

4.2.3.104

(2E,6E)-farnesyl diphosphate = alpha-humulene + diphosphate

0

7oc4, 3D-view

4.2.3.57

(2E,6E)-farnesyl diphosphate = (-)-beta-caryophyllene + alpha-humulene + diphosphate

0

-

4.2.3.57

(2E,6E)-farnesyl diphosphate = (E)-beta-caryophyllene + alpha-humulene + germacrene + diphosphate

0

-

4.2.3.57

2 entries

Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Substrate (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.14.113

alpha-humulene + O2 + [reduced NADPH-hemoprotein reductase] = 10-hydroxy-alpha-humulene + [oxidized NADPH-hemoprotein reductase] + H2O

717135, 717593, 717468

-

Product in Enzyme-catalyzed Reactions (7 results)

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Show Product (7 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

4.2.3.104

(2E,6E)-farnesyl diphosphate = alpha-humulene + diphosphate

0

7oc4, 3D-view

4.2.3.104

2 (2E,6E)-farnesyl diphosphate = beta-caryophyllene + alpha-humulene + 2 diphosphate

0

7oc4, 3D-view

4.2.3.104

4 (2E,6E)-farnesyl diphosphate = guaia-1(10),11-diene + guaia-1(5),11-diene + alpha-humulene + beta-elemene + 4 diphosphate

0

7oc4, 3D-view

4.2.3.57

(2E,6E)-farnesyl diphosphate = (-)-beta-caryophyllene + alpha-humulene + diphosphate

0

-

4.2.3.57

(2E,6E)-farnesyl diphosphate = (E)-beta-caryophyllene + alpha-humulene + alpha-copaene + diphosphate

0

-

4.2.3.57

(2E,6E)-farnesyl diphosphate = (E)-beta-caryophyllene + alpha-humulene + diphosphate

0

-

4.2.3.57

(2E,6E)-farnesyl diphosphate = (E)-beta-caryophyllene + alpha-humulene + germacrene + diphosphate

0

-

4.2.3.104

3 entries

4.2.3.57

4 entries

3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

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Show 3D Structure of Enzyme-Ligand-Complex (PDB) (1 entry)

EC NUMBER

ENZYME 3D STRUCTURE

4.2.3.104

7oc4, 3D-view

Enzyme Kinetic Parameters

References & Links

Literature References (3)

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Show Reference (3 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

717135

21229242

Efficient functional analysis system for cyanobacterial or plant cytochromes P450 involved in sesquiterpene biosynthesis

2011

Harada, H.; Shindo, K.; Iki, K.; Teraoka, A.; Okamoto, S.; Yu, F.; Hattan, J.; Utsumi, R.; Misawa, N.

Appl. Microbiol. Biotechnol.

90

467-476

717468

20730551

Zingiber zerumbet CYP71BA1 catalyzes the conversion of ?-humulene to 8-hydroxy-alpha-humulene in zerumbone biosynthesis

2011

Yu, F.; Okamoto, S.; Harada, H.; Yamasaki, K.; Misawa, N.; Utsumi, R.

Cell. Mol. Life Sci.

68

1033-1040

717593

21668645

A short-chain dehydrogenase involved in terpene metabolism from Zingiber zerumbet

2011

Okamoto, S.; Yu, F.; Harada, H.; Okajima, T.; Hattan, J.; Misawa, N.; Utsumi, R.

FEBS J.

278

2892-2900

Links to other databases for alpha-humulene

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Show Links (1 entry)

ChEBI

PubChem