Ligand 1-Hexanol

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Basic Ligand Information

Molecular Structure
Picture of 1-Hexanol (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H14O
1-Hexanol
NGMQPNCYPQQQSS-AMWOSJAMSA-N
Synonyms:
1hexanol, hexan-1-ol, Hexanol, hexyl alcohol, n-Hexanol
Pathway Source
Pathways

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
1-hexanol + NAD(P)+ = hexanal + NAD(P)H + H+
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
hexanal + NAD(P)H + H+ = hexan-1-ol + NAD(P)+
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (56 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
n-hexanol + NAD+ + H2O = n-hexanal + NADH
show the reaction diagram
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1-hexanol + NAD+ = hexanal + NADH
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1-hexanol + NAD+ = hexanal + NADH + H+
show the reaction diagram
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n-hexanol + NAD+ = n-hexanal + NADH
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1-hexanol + ferricytochrome c = hexanal + ferrocytochrome c + H+
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1-hexanol + O2 = n-hexanal + H2O2
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hexanol + O2 = hexanal + H2O2
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1-hexanol + ferricyanide = hexanal + ferrocyanide
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n-hexanol + acceptor = n-hexanal + reduced acceptor
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1-hexanol + acceptor = n-hexanal + reduced acceptor
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1-hexanol + N,N-dimethyl-4-nitrosoaniline = hexanal + 4-(hydroxylamino)-N,N-dimethylaniline
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n-hexanol + NAD+ + H2O = ? + NADH
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n-hexanol + p-nitroso-N,N-dimethylaniline = n-hexanal + reduced p-nitroso-N,N-dimethylaniline
show the reaction diagram
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UDP-glucose + 1-hexanol = UDP + hexyl beta-D-glucoside
show the reaction diagram
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3'-phosphoadenylylsulfate + 1-hexanol = adenosine 3',5'-bisphosphate + 1-hexyl sulfate
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gallate + 1-hexanol = 1-hexyl gallate + H2O
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phosphatidylcholine + hexanol = phosphatidylhexanol + choline
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beta-D-Gal-(1-3)-alpha-D-GalNAc-(1-O)-p-nitrophenyl + 1-hexanol = beta-D-Gal-(1-3)-alpha-D-GalNAc-(1-O)-hexyl + p-nitrophenol
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (53 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
hexanal + NADPH = hexan-1-ol + NADPH + H+
show the reaction diagram
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hexanal + NADPH + H+ = hexanol + NADP+
show the reaction diagram
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hexanal + NADH + H+ = hexanol + NAD+
show the reaction diagram
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hexanal + NADPH = hexanol + NADP+
show the reaction diagram
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hexane + NADH + H+ + O2 = hexan-1-ol + NAD+ + H2O
show the reaction diagram
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hexane + NAD(P)H + O2 = 1-hexanol + 2-hexanol + NAD(P)+ + H2O
show the reaction diagram
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n-hexyl laurate + H2O = n-hexanol + lauric acid
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n-hexyl ferulate + H2O = ferulate + n-hexanol
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n-hexyl acetate + H2O = n-hexanol + acetate
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hexyl-beta-D-glucoside + H2O = hexanol + D-glucose
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n-hexyl-beta-D-glucopyranoside + H2O = n-hexanol + D-glucose
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n-hexyl beta-D-glucopyranoside + H2O = 1-hexanol + beta-D-glucose
show the reaction diagram
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6-hydroxyhexylflavin + H2O = hexanol + lumichrome
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
20 mM, activates
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about 140% activity at 25% (v/v)
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addition of 20% v/v n-octanol results in an over 40fold higher activity of 4-nitrophenyl-beta-D-glucopyranoside hydrolysis, and activation of transglycosylation activity, overview
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Inhibitor in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
the enzymatic activity of horseradish peroxidase decreases upon addition of n-hexanol
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substrate formaldehyde
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68% inhibition at 40% v/v; 86% inhibition at 40% v/v
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about 5% residual activity at 10% (w/v)
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3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (26 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
10.7
-
pH 7.0, 25C
2.55
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in the presence of NADP+
483
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pH 7.5, 30C
0.06
-
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0.417
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pH 7.5, 37C

KM Value (52 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
1.22
-
presence of NADP+
3.4
-
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2.4
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wild-type, temperature not specified in the publication, pH not specified in the publication
1.53
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pH 7.5, 30C
0.66
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Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
2.3
-
substrate formaldehyde

References & Links

Links to other databases for 1-Hexanol

ChEBI
PubChem
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PubChem