Ligand HOCl

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Basic Ligand Information

Molecular Structure
Picture of HOCl (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
HClO
HOCl
QWPPOHNGKGFGJK-UHFFFAOYSA-N
Synonyms:
HClO, hypochlorous acid

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
donor + HOCl = oxidized donor + Cl-
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
Cl- + H2O2 + H+ = HOCl + H2O
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
HOCl + dithiothreitol = ?
show the reaction diagram
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donor + HOCl = oxidized donor + Cl-
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
Cl- + H2O2 + H+ = HOCl + H2O
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
HOCl can oxidize methionine to methionine sulfoxide and tyrosine to chlorotyrosine, oxidation of VWF A2 peptide, at Met1606 and Tyr1605, markedly impairs ADAMTS13 cleavage. Oxidative modification by myeloperoxidase/H2O2 is similar to that produced by HOCl
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inhibits the muclear NTPase, taurine acts as antagonist and reduces the hypochlorous acid toxicity
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exposure of human coronary artery endothelial cells to 0-50 microM HOCl or 0-150 microM HOSCN results in an increase in intracellular iron, loss of aconitase activity and a loss of mitochondrial aconitase protein. Cytosolic aconitase is not affected
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Enzyme Kinetic Parameters

IC50 Value (2 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE

References & Links

Links to other databases for HOCl

ChEBI
PubChem
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PubChem