BRENDA - Ligand view of 2-iminoacetate (12117 - TVMUHOAONWHJBV-UHFFFAOYSA-N)

C₂H₃NO₂

2-iminoacetate

TVMUHOAONWHJBV-UHFFFAOYSA-N

BRENDA

KEGG

Biosynthesis of cofactors, Thiamine metabolism

MetaCyc

3PG-factor 420 biosynthesis, factor 420 biosynthesis I (archaea), factor 420 biosynthesis II (mycobacteria), thiazole component of thiamine diphosphate biosynthesis I, thiazole component of thiamine diphosphate biosynthesis II

1.4.3.19

2-iminoacetate + H2O = glyoxylate + NH3

742898, 742945, 742686, 743639, 741594

-

2.8.1.10

1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + thiocarboxy-adenylate-[sulfur-carrier protein ThiS] = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS] + 2 H2O

737721, 739422

-

1.4.3.19

glycine + O2 = 2-iminoacetate + H2O2

-

2.5.1.147

5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine = 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + 2-iminoacetate + L-methionine + 5'-deoxyadenosine

-

1.4.3.19

2-iminoacetate + H2O = glyoxylate + NH3

742898, 742945, 742686, 743639, 741594

-

2.8.1.10

1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + thiocarboxy-adenylate-[sulfur-carrier protein ThiS] = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS] + 2 H2O

737721, 739422, 715306, 708874, 707466

-

1.4.3.19

glycine + O2 = 2-iminoacetate + H2O2

-

2.5.1.147

5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine = 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + 2-iminoacetate + L-methionine + 5'-deoxyadenosine

-

4.1.99.19

L-tyrosine + S-adenosyl-L-methionine + reduced acceptor = 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + acceptor + 2 H+

-

707466

14567704

Biosynthesis of the thiazole moiety of thiamin pyrophosphate (vitamin B1)

2003

Park, J.H.; Dorrestein, P.C.; Zhai, H.; Kinsland, C.; McLafferty, F.W.; Begley, T.P.

Biochemistry

42

12430-12438

708874

19216519

Biosynthesis of the thiamin thiazole in Bacillus subtilis: identification of the product of the thiazole synthase-catalyzed reaction

2009

Hazra, A.; Chatterjee, A.; Begley, T.P.

J. Am. Chem. Soc.

131

3225-3229

715306

21534620

A missing enzyme in thiamin thiazole biosynthesis: identification of TenI as a thiazole tautomerase

2011

Hazra, A.B.; Han, Y.; Chatterjee, A.; Zhang, Y.; Lai, R.Y.; Ealick, S.E.; Begley, T.P.

J. Am. Chem. Soc.

133

9311-9319

737721

26919468

Structural Basis for iron-mediated sulfur transfer in archael and yeast thiazole synthases

2016

Zhang, X.; Eser, B.E.; Chanani, P.K.; Begley, T.P.; Ealick, S.E.

Biochemistry

55

1826-1838

739422

26222282

The thiG gene is required for full virulence of Xanthomonas oryzae pv. oryzae by preventing cell aggregation

2015

Yu, X.; Liang, X.; Liu, K.; Dong, W.; Wang, J.; Zhou, M.G.

PLoS ONE

10

e0134237

741594

25321325

Glycine oxidase based high-throughput solid-phase assay for substrate profiling and directed evolution of (R)- and (S)-selective amine transaminases

2014

Weiss, M.S.; Pavlidis, I.V.; Vickers, C.; Hoehne, M.; Bornscheuer, U.T.

Anal. Chem.

86

11847-11853

742686

26025077

Improvement of glycine oxidase by DNA shuffling, and site-saturation mutagenesis of F247 residue

2015

Yao, P.; Lin, Y.; Wu, G.; Lu, Y.; Zhan, T.; Kumar, A.; Zhang, L.; Liu, Z.

Int. J. Biol. Macromol.

79

965-970

742898

27637328

Roles of conserved residues of the glycine oxidase GoxA in controlling activity, cooperativity, subunit composition, and cysteine tryptophylquinone biosynthesis

2016

Sehanobish, E.; Williamson, H.R.; Davidson, V.L.

J. Biol. Chem.

291

23199-23207

742945

24905148

Expression of an evolved engineered variant of a bacterial glycine oxidase leads to glyphosate resistance in alfalfa

2014

Nicolia, A.; Ferradini, N.; Molla, G.; Biagetti, E.; Pollegioni, L.; Veronesi, F.; Rosellini, D.

J. Biotechnol.

184

201-208

743639

24223901

Improving glyphosate oxidation activity of glycine oxidase from Bacillus cereus by directed evolution

2013

Zhan, T.; Zhang, K.; Chen, Y.; Lin, Y.; Wu, G.; Zhang, L.; Yao, P.; Shao, Z.; Liu, Z.

PLoS ONE

8

e79175

-

Ligand 2-iminoacetate

Basic Ligand Information

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

Substrate in Enzyme-catalyzed Reactions (2 results)

Product in Enzyme-catalyzed Reactions (3 results)

Enzyme Kinetic Parameters

References & Links

Literature References (10)

Links to other databases for 2-iminoacetate