Ligand gamma-Glu-L-Cys

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Basic Ligand Information

Molecular Structure
Picture of gamma-Glu-L-Cys (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C8H14N2O5S
gamma-Glu-L-Cys
RITKHVBHSGLULN-WHFBIAKZSA-N
Synonyms:
5-L-glutamyl-Cys, 5-L-glutamyl-cysteine, 5-L-glutamyl-L-Cys, 5-L-glutamyl-L-cysteine, gamma-Glu-Cys, gamma-glutamyl-Cys, gamma-glutamylcysteine, gamma-L-Glu-L-Cys, gamma-L-glutamyl-L-cysteine, L-gamma-Glu-L-Cys, L-gamma-glutamylcysteine


Show all pahtways known for Show all BRENDA pathways known for gamma-Glu-L-Cys

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (20 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
hercynine + gamma-L-glutamyl-L-cysteine + O2 = gamma-L-glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide + H2O
show the reaction diagram
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hercynine + gamma-L-glutamyl-L-cysteine + O2 = gamma-L-glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide + H2O
show the reaction diagram
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hercynine + gamma-L-glutamyl-L-cysteine + O2 = gamma-L-glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide + H2O
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
bis-gamma-glutamylcystine + NADPH + H+ = 2 gamma-glutamylcysteine + NADP+
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (116 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
hercynine + gamma-L-glutamyl-L-cysteine + O2 = gamma-L-glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide + H2O
show the reaction diagram
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hercynine + gamma-L-glutamyl-L-cysteine + O2 = gamma-L-glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide + H2O
show the reaction diagram
-
hercynine + gamma-L-glutamyl-L-cysteine + O2 = gamma-L-glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide + H2O
show the reaction diagram
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gamma-Glu-Cys + Gly-Gly = Cys + 5-L-glutamyl-Gly-Gly
show the reaction diagram
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gamma-L-glutamyl-L-cysteine + H2O = ?
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (11 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
bis-gamma-glutamylcystine + NADPH + H+ = 2 gamma-glutamylcysteine + NADP+
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
best activation system: 1 mM Fe(II) and 2 mM cysteine, L-cysteine can be replaced by D-cysteine, DL-penicillamine or gamma-L-glutamyl-L-cysteine
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Inhibitor in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

3D Structure of Enzyme-Ligand-Complex (PDB) (37 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (39 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.461
-
pH and temperature not specified in the publication

KM Value (58 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
7.68
-
pH and temperature not specified in the publication

Ki Value (6 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
3.7
-
pH 7.4, 38C

References & Links

Links to other databases for gamma-Glu-L-Cys

ChEBI
PubChem
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PubChem