Ligand coniferyl alcohol

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Basic Ligand Information

Molecular Structure
Picture of coniferyl alcohol (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C10H12O3
coniferyl alcohol
JMFRWRFFLBVWSI-NSCUHMNNSA-N
Synonyms:
3-methoxycaffeoyl alcohol, 4-(3-hydroxyprop-1-en-1-yl)-2-methoxyphenol, 4-[(1E)-3-hydroxyprop-1-en-1-yl]-2-methoxyphenol, coniferol


Show all pahtways known for Show all BRENDA pathways known for coniferyl alcohol

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
coniferyl alcohol + NADP+ = coniferyl aldehyde + NADPH + H+
show the reaction diagram
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UDPglucose + coniferyl alcohol = ?
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
coniferyl aldehyde + NADPH + H+ = coniferyl alcohol + NADP+
show the reaction diagram
-
-
coniferin + H2O = D-glucose + coniferol
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (23 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
coniferyl alcohol + NADP+ = coniferyl aldehyde + NADPH + H+
show the reaction diagram
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coniferyl alcohol + NADP+ = coniferylaldehyde + NADPH + H+
show the reaction diagram
-
coniferyl alcohol + O2 = coniferyl aldehyde + H2O2
show the reaction diagram
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coniferyl alcohol + H2O2 = ?
show the reaction diagram
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coniferyl alcohol + [reduced NADPH-hemoprotein reductase] + O2 = 5-hydroxyconiferyl alcohol + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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coniferyl alcohol + O2 = coniferyl aldehyde + H2O2
show the reaction diagram
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S-adenosyl-L-methionine + coniferyl alcohol = S-adenosyl-L-homocysteine + sinapyl alcohol
show the reaction diagram
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benzoyl-CoA + coniferyl alcohol = coniferyl benzoate + CoA
show the reaction diagram
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coniferyl alcohol + acetyl-CoA = coniferyl acetate + CoA
show the reaction diagram
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UDP-glucose + coniferyl alcohol = UDP + coniferin
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (17 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
coniferyl aldehyde + NADPH + H+ = coniferyl alcohol + NADP+
show the reaction diagram
-
-
coniferaldehyde + NADPH = coniferyl alcohol + NADP+
show the reaction diagram
-
-
coniferyl aldehyde + NADH + H+ = coniferyl alcohol + NAD+
show the reaction diagram
-
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coniferyl aldehyde + NADH + H+ = coniferyl alcohol + NAD+
show the reaction diagram
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ferulic acid + NADPH + ATP = ferulic acid + coniferyl aldehyde + coniferyl alcohol + NADP+ + AMP + phosphate
show the reaction diagram
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S-adenosyl-L-methionine + caffeoyl alcohol = S-adenosyl-L-homocysteine + coniferyl alcohol
show the reaction diagram
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coniferyl p-coumarate + H2O = p-coumaric acid + coniferol
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
the enzyme is inhibited by an excess of coniferyl alcohol from 0.017 mM
-
competitive mechanism, substrate inhibition
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above 0.08 mM, Paul's scarlet rose
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competitive
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3D Structure of Enzyme-Ligand-Complex (PDB) (15 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (17 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
25.8
-
recombinant enzyme, at pH 8.5 and 40°C

KM Value (42 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.55
-
-
0.002
-
isoenzyme lac90
0.003
-
pH 7.8, 30°C

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.032
-
pH 8.5, 55°C

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.000034
-
pH 6.5, 41°C, recombinant enzyme

References & Links

Links to other databases for coniferyl alcohol

ChEBI
PubChem
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PubChem