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Ligand coenzyme F420-1 Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information Molecular Structure
C2 4 H2 9 N4 O1 5 P
coenzyme F420-1
WVEYWCGUSMKKMF-LADHFWMSSA-N
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
L-glutamate + GTP + coenzyme F420-1 = GDP + phosphate + coenzyme gamma-F420-2
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L-glutamate + GTP + coenzyme gamma-F420-1 = GDP + phosphate + coenzyme gamma-F420-2
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In Vivo Product in Enzyme-catalyzed Reactions (3 results)Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
GTP + coenzyme F420-0 + L-glutamate = GDP + phosphate + coenzyme F420-1
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L-glutamate + GTP + coenzyme F420-0 = GDP + phosphate + coenzyme gamma-F420-1
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GTP + coenzyme F420-0 + L-glutamate = GDP + phosphate + coenzyme F420-1
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Substrate in Enzyme-catalyzed Reactions (5 results)
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GTP + coenzyme F420-1 + L-glutamate = GDP + phosphate + coenzyme gamma-F420-2
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L-glutamate + GTP + coenzyme F420-1 = GDP + phosphate + coenzyme gamma-F420-2
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L-glutamate + dGTP + coenzyme gamma-F420-1 = dGDP + phosphate + coenzyme gamma-F420-2
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L-glutamate + GTP + coenzyme gamma-F420-1 = GDP + phosphate + coenzyme gamma-F420-2
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L-glutamate + UTP + coenzyme gamma-F420-1 = UDP + phosphate + coenzyme gamma-F420-2
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Product in Enzyme-catalyzed Reactions (8 results)
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GTP + coenzyme F420-0 + L-glutamate = GDP + phosphate + coenzyme F420-1
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L-glutamate + ATP + coenzyme F420-0 = ADP + phosphate + coenzyme F420-1
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L-glutamate + dGTP + coenzyme F420-0 = dGDP + phosphate + coenzyme F420-1
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L-glutamate + GTP + coenzyme F420-0 = GDP + phosphate + coenzyme F420-1
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L-glutamate + UTP + coenzyme F420-0 = UDP + phosphate + coenzyme F420-1
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L-glutamate + GTP + coenzyme F420-0 = GDP + phosphate + coenzyme gamma-F420-1
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GTP + coenzyme F420-0 + L-glutamate = GDP + phosphate + coenzyme F420-1
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L-glutamate + dGTP + coenzyme F420-0 = dGDP + phosphate + coenzyme F420-1
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Enzyme Kinetic Parameters
KM Value (1 result)
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References & Links Literature References (4)
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CofE catalyzes the addition of two glutamates to F420-0 in F420 coenzyme biosynthesis in Methanococcus jannaschii
2003
Li, H.; Graupner, M.; Xu, H.; White, R.H.
Biochemistry
42
9771-9778
Structure of an amide bond forming F(420):gamma-glutamyl ligase from Archaeoglobus fulgidus - a member of a new family of non-ribosomal peptide synthases
2007
Nocek, B.; Evdokimova, E.; Proudfoot, M.; Kudritska, M.; Grochowski, L.L.; White, R.H.; Savchenko, A.; Yakunin, A.F.; Edwards, A.; Joachimiak, A.
J. Mol. Biol.
372
456-469
Elongation of the poly-gamma-glutamate tail of F420 requires both domains of the F420 gamma-glutamyl ligase (FbiB) of Mycobacterium tuberculosis
2016
Bashiri, G.; Rehan, A.; Sreebhavan, S.; Baker, H.; Baker, E.; Squire, C.
J. Biol. Chem.
291
6882-6894
Coenzyme F420-dependent glucose-6-phosphate dehydrogenase-coupled polyglutamylation of coenzyme F420 in Mycobacteria
2018
Purwantini, E.; Loganathan, U.; Mukhopadhyay, B.
J. Bacteriol.
200
e00375-18
Links to other databases for coenzyme F420-1
Show all BRENDA pathways known for coenzyme F420-1
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