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0.0032
-
wild-type protein, pH7.5, 25°C
0.0000076
-
mutant F64P, pH 7.5, 25°C
0.00001
-
below, mutant F64P, pH 7.5, 25°C
0.000046
-
mutant G113N, pH 7.5, 25°C
0.00015
-
pH 7.5, 25°C, mutant enzyme E232G
0.0002
-
multiple turnovers, mutant H90Q, pH 7.5, 25°C
0.00045
-
mutant G113S, pH 7.5, 25°C
0.002
-
mutant G114A, pH 7.5, 25°C
0.005
-
mutant G113A, pH 7.5, 25°C
0.008
-
mutant G113A, pH 7.5, 25°C
0.016
-
single turnover, mutant H90Q, pH 7.5, 25°C
0.03
-
mutant F64A, pH 7.5, 25°C
0.13
-
mutant A112V, pH 7.5, 25°C
0.14
-
mutant R257L, pH 7.5, 25°C
0.33
-
mutant R24L, pH 7.5, 25°C
0.38
-
mutant R67K, pH 7.5, 25°C
0.44
-
mutant Y65D, pH 7.5, 25°C
0.55
-
mutant R257K, pH 7.5, 25°C
0.6
-
pH 7.5, 25°C, wild-type enzyme
0.6
-
wild-type enzyme, pH 7.5, 25°C
0.7
-
multiple turnovers, wild-type enzyme, pH 7.5, 25°C
0.95
-
mutant R24K, pH 7.5, 25°C
2.3
-
single turnover, wild-type enzyme, pH 7.5, 25°C
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0.13
-
wild-type protein, pH7.5, 25°C
0.0037
-
pH 7.5, 25°C, wild-type enzyme
0.0037
-
wild-type enzyme, pH 7.5, 25°C
0.0052
-
mutant F64A, pH 7.5, 25°C
0.0058
-
mutant R257K, pH 7.5, 25°C
0.0066
-
mutant A112V, pH 7.5, 25°C
0.0069
-
mutant R67K, pH 7.5, 25°C
0.011
-
mutant Y65D, pH 7.5, 25°C
0.014
-
mutant G113A, pH 7.5, 25°C
0.021
-
mutant R24K, pH 7.5, 25°C
0.026
-
mutant G113A, pH 7.5, 25°C
0.041
-
mutant R24L, pH 7.5, 25°C
0.062
-
mutant G113S, pH 7.5, 25°C
0.07
-
mutant R257L, pH 7.5, 25°C
0.11
-
mutant G114A, pH 7.5, 25°C
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Acyl-adenylate motif of the acyl-adenylate/thioester-forming enzyme superfamily: a site-directed mutagenesis study with the Pseudomonas sp. strain CBS3 4-chlorobenzoate:coenzyme A ligase
1997
Chang, K.H.; Xiang, H.; Dunaway-Mariano, D.
Biochemistry
36
15650-15659
Isolation and characterization of the three polypeptide components of 4-chlorobenzoate dehalogenase from Pseudomonas sp. strain CBS-3
1992
Chang, K.H.; Liang, P.H.; Beck, W.; Scholten, J.D.; Dunaway-Mariano, D.
Biochemistry
31
5605-5610
On the origins and functions of the enzymes of the 4-chlorobenzoate to 4-hydroxybenzoate converting pathway
1994
Dunaway-Mariano, D.; Babbitt, P.C.
Biodegradation
5
259-276
Purification and characterization of 4-chlorobenzoyl CoA dehalogenase from Arthrobacter sp. strain 4-CB1
1994
Crooks, G.P.; Copley, S.D.
Biochemistry
33
11645-11649
Specificity of 4-chlorobenzoyl coenzyme A dehalogenase catalyzed dehalogenation of halogenated aromatics
1993
Liang, P.H.; Yang, G.; Dunaway-Mariano, D.
Biochemistry
32
12245-12250
Dehalogenation of 4-chlorobenzoate. Characterisation of 4-chlorobenzoyl-coenzyme A dehalogenase from Pseudomonas sp. CBS3
1995
Löffler, F.; Lingens, F.; Muller, R.
Biodegradation
6
203-212
NADPH-dependent reductive ortho dehalogenation of 2,4-dichlorobenzoic acid in Corynebacterium sepedonicum KZ-4 and Coryneform Bacterium strain NBT-1 via 2,4-dichlorobenzoyl coenzym A
1996
Romanov, V.; Hausinger, R.P.
J. Bacteriol.
178
2656-2661
Molecular specificity of a medium chain acyl-CoA synthetase for substrates and inhibitors: conformational analysis
1998
Kasuya, F.; Yamaoka, Y.; Igarashi, K.; Fukui, M.
Biochem. Pharmacol.
55
1769-1775
Characterization of a renal medium chain acyl-CoA synthetase responsible for glycine conjugation in mouse kidney mitochondria
1999
Kasuya, F.; Igarashi, K.; Fukui, M.
Chem. Biol. Interact.
118
233-246
Histidine 90 function in 4-chlorobenzoyl-coenzyme A dehalogenase catalysis
2001
Zhang, W.; Wei, Y.; Luo, L.; Taylor, K.L.; Yang, G.; Dunaway-Mariano, D.; Benning, M.M.; Holden, H.M.
Biochemistry
40
13474-13482
Role of active site binding interactions in 4-chlorobenzoyl-coenzyme A dehalogenase catalysis
2001
Luo, L.; Taylor, K.L.; Xiang, H.; Wei, Y.; Zhang, W.; Dunaway-Mariano, D.
Biochemistry
40
15684-15692
The strength of dehalogenase-substrate hydrogen bonding correlates with the rate of Meisenheimer intermediate formation
2003
Dong, J.; Lu, X.; Wei, Y.; Luo, L.; Dunaway-Mariano, D.; Carey, P.R.
Biochemistry
42
9482-9490
-
A QM/MM study of a nucleophilic aromatic substitution reaction catalyzed by 4-chlorobenzoyl-CoA dehalogenase
2004
Xu, D.; Guo, H.; Gao, J.; Cui, Q.
Chem. Commun. (Camb.)
2004
892-893
The active site dynamics of 4-chlorobenzoyl-CoA dehalogenase
2001
Lau, E.Y.; Bruice, T.C.
Proc. Natl. Acad. Sci. USA
98
9527-9532
The purification and characterisation of 4-chlorobenzoate:CoA ligase and 4-chlorobenzoyl CoA dehalogenase from Arthrobacter sp. strain TM-1
2004
Zhou, L.; Marks, T.S.; Poh, R.P.; Smith, R.J.; Chowdhry, B.Z.; Smith, A.R.
Biodegradation
15
97-109
Contributions of long-range electrostatic interactions to 4-chlorobenzoyl-CoA dehalogenase catalysis: a combined theoretical and experimental study
2006
Wu, J.; Xu, D.; Lu, X.; Wang, C.; Guo, H.; Dunaway-Mariano, D.
Biochemistry
45
102-112
Electrostatic influence of active-site waters on the nucleophilic aromatic substitution catalyzed by 4-chlorobenzoyl-CoA dehalogenase
2005
Xu, D.; Guo, H.
FEBS Lett.
579
4249-4253
QM/MM studies of the enzyme-catalyzed dechlorination of 4-chlorobenzoyl-CoA provide insight into reaction energetics
2004
Xu, D.; Wei, Y.; Wu, J.; Dunaway-Mariano, D.; Guo, H.; Cui, Q.; Gao, J.
J. Am. Chem. Soc.
126
13649-13658
-
Raman evidence for product binding to the enzyme W137F 4-chlorobenzoyl-CoA dehalogenase in two conformational states
2005
Dong, J.; Luo, L.; Dunaway-Mariano, D.; Carey, P.R.
J. Raman Spectros.
36
320-325
Structure-activity analysis of base and enzyme-catalyzed 4-hydroxybenzoyl coenzyme A hydrolysis
2007
Song, F.; Zhuang, Z.; Dunaway-Mariano, D.
Bioorg. Chem.
35
1-10
Structure and denaturation of 4-chlorobenzoyl coenzyme A dehalogenase from Arthrobacter sp. strain TM-1
2008
Zhou, L.; Poh, R.P.; Marks, T.S.; Chowdhry, B.Z.; Smith, A.R.
Biodegradation
19
65-75
The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis
2009
Cao, J.; Xu, H.; Zhao, H.; Gong, W.; Dunaway-Mariano, D.
Biochemistry
48
1293-1304
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