Ligand 4-Aminobenzoic acid

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Basic Ligand Information

Molecular Structure
Picture of 4-Aminobenzoic acid (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C7H7NO2
4-Aminobenzoic acid
ASBJGPTTYPEMLP-REOHCLBHSA-N
Synonyms:
4(or 2)-aminobenzoate, 4-amino-1-benzoic acid, 4-Aminobenzoate, 4-amino benzoic acid, 4-carboxyphenylamine, p-Aminobenzoate, p-Aminobenzoic acid, pABA


Show all pahtways known for Show all BRENDA pathways known for 4-Aminobenzoic acid

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (25 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
4-aminobenzoate + reduced acceptor + 2 O2 = 4-nitrobenzoate + acceptor + 2 H2O
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4-nitrophenyl acetate + 4-aminobenzoic acid = 4-nitrophenol + N-acetyl-4-aminobenzoic acid
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In Vivo Product in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
4-aminobenzoylglutamate + H2O = 4-aminobenzoic acid + L-glutamate
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4-amino-4-deoxychorismate = 4-aminobenzoate + pyruvate
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Substrate in Enzyme-catalyzed Reactions (76 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
4-aminobenzoic acid + H2O2 = ?
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4-aminobenzoic acid + H2O2 = ? + H2O
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4-aminobenzoate + ? = 4-amino-3-hydroxybenzoate + ?
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4-aminobenzoate + NADH + O2 = 4-amino-3-hydroxybenzoate + NAD+ + H2O
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4-aminobenzoate + reduced phenazine methosulfate + 2 O2 = 4-nitrobenzoate + phenazine methosulfate + 2 H2O
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4-aminobenzoate + reduced acceptor + 2 O2 = 4-nitrobenzoate + acceptor + 2 H2O
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4-aminobenzoic acid + UDP-glucose = UDP + 4-aminobenzoyl-beta-D-glucoside
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UDPglucose + p-aminobenzoic acid = ?
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thiamine + p-aminobenzoic acid = 4-methyl-5-(2-hydroxyethyl)-thiazole + 4-[[(4-amino-2-methylpyrimidin-5-yl)methyl]amino]benzoic acid
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4-Aminobenzoate = Aniline + CO2
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ATP + 4-aminobenzoate + CoA = AMP + diphosphate + 4-aminobenzoyl-CoA
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ATP + 4-aminobenzoate + CoA = AMP + diphosphate + 4-aminobenzoyl-CoA
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ATP + 4-aminobenzoate + CoA = AMP + 4-aminobenzoyl-CoA + diphosphate
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Product in Enzyme-catalyzed Reactions (42 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5'-phospho-pyridoxyl-4-aminobenzoate + H2O + O2 = pyridoxal 5'-phosphate + 4-aminobenzoate + H2O2
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lipoyl 4-aminobenzoate + H2O = 4-aminobenzoate + lipoic acid
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4-aminobenzoyl-Ala + H2O = 4-aminobenzoate + Ala
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4-aminobenzoyl-gamma-Glu + H2O = 4-aminobenzoate + Glu
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p-aminobenzamidine + H2O = p-aminobenzoic acid + NH3
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N-Benzoyl-L-tyrosyl-4-aminobenzoate + H2O = N-Benzoyl-L-tyrosine + 4-aminobenzoate
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4-aminobenzoyl-glutamate + H2O = 4-aminobenzoate + glutamate
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4-aminobenzamide + H2O = 4-aminobenzoic acid + NH3
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4-(glutarylamino)benzoic acid + H2O = glutarate + 4-aminobenzoate
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4-aminobenzoylglutamate + H2O = 4-aminobenzoic acid + L-glutamate
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4-aminophenyl acetonitrile + H2O = 4-aminobenzoic acid + NH3
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4-aminobenzonitrile + 2 H2O = 4-aminobenzoic acid + NH3
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4-amino-4-deoxychorismate = 4-aminobenzoate + pyruvate
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (32 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
over 70% inhibition at 10 mM
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about 30% inhibition at 0.2 mM
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0.1 mM: no inhibition, 30% inhibition at 1.0 mM
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maximal inhibition of 8% (highest inhibition achieved relative to that in absence of inhibitor by varying the concentration of the inhibitor at a given concentration of other substrates pyruvate 0.5 mM and 0.4 mM L-aspartate-4-semialdehyde), in a coupled assay with recombinant dihydrodipicolinate reductase
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3D Structure of Enzyme-Ligand-Complex (PDB) (73 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (44 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.104
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pH 7.4, 20°C
0.18
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pH 8.0, 31°C, recombinant wild-type enzyme

KM Value (82 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0052
-
pH 7.4, 20°C
0.4371
-
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200
-
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0.025
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pH 8.0, 31°C, recombinant wild-type enzyme

Ki Value (6 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.05
-
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1.4
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IC50 Value (3 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE

References & Links

Links to other databases for 4-Aminobenzoic acid

ChEBI
PubChem
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PubChem