Ligand oxidized dithiothreitol

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Basic Ligand Information

Molecular Structure
Picture of oxidized dithiothreitol (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C4H8O2S2
oxidized dithiothreitol
YPGMOWHXEQDBBV-ZXZARUISSA-N
Synonyms:
1,4-dithioerythritol disulfide, 4,5-cis-dihydroxy-1,2-dithiacyclohexane, 4,5-cis-dihydroxy-1,2-dithiacyclohexane (i.e. oxidized dithioerythritol), oxidized dithioerythritol

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol = 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol
show the reaction diagram
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unofolded bovine pancreatic ribonuclease A + oxidized dithiothreitol = refolded bovine pancreatic ribonuclease A + reduced dithiothreitol
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Product in Enzyme-catalyzed Reactions (50 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
CDP + reduced dithiothreitol = dCDP + oxidized dithiothreitol + H2O
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protochlorophyllide + dithiothreitol = chlorophyllide + oxidized dithiothreitol
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7,8-dihydromethanopterin + reduced dithiothreitol = 5,6,7,8-tetrahydromethanopterin + oxidized dithiothreitol
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5,5'-dithiobis(2-nitrobenzoic acid) + dithiothreitol = 2-nitro-5-thiobenzoate + oxidized dithiothreitol
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5'-adenylyl sulfate + reduced dithiothreitol = AMP + sulfite + oxidized dithiothreitol
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dabsyl-L-methionine (R)-sulfoxide + 1,4-dithioerythritol = dabsyl-L-methionine + 1,4-dithioerythritol disulfide + H2O
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insulin + dithiothreitol = reduced insulin + oxidized dithiothreitol
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reduced dithiothreitol + NADP+ = oxidized dithiothreitol + NADPH + H+
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[insulin]-disulfide + reduced dithiothreitol = [insulin]-dithiol + oxidized dithiothreitol
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S-adenosyl-L-methionine + cobalt(II)-factor-III + dithiothreitol = S-adenosyl-L-homocysteine + cobalt(II)-precorrin-4 + oxidized dithiothreitol
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thiosulfate + dithiothreitol = sulfite + oxidized dithiothreitol + sulfide
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Insulin-(SS) + dithiothreitol = Insulin-(SH)2 + oxidized dithiothreitol
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Inhibitor in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
in the absence of Mg2+, the enzyme is strongly inhibited by oxidation, retaining 20-30 % of its control activity when exposed to 50 mM oxidized dithiothreitol. The apoenzyme is 80% inactivated following incubation in the presence of identical amount of oxidized dithiothreitol
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Enzyme Kinetic Parameters

References & Links

Links to other databases for oxidized dithiothreitol

ChEBI
PubChem
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PubChem