Ligand lanosterol

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Basic Ligand Information

Molecular Structure
Picture of lanosterol (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C30H50O
lanosterol
CAHGCLMLTWQZNJ-BQNIITSRSA-N
Synonyms:
4,4',14alpha-trimethyl-5alpha-cholesta-8,24-dien-3beta-ol, 5alpha-Lanosta-8,24-dien-3beta-ol


Show all pahtways known for Show all BRENDA pathways known for lanosterol

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
lanosterol + NAD(P)+ = lanosterone + NAD(P)H + CO2 + H+
show the reaction diagram
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lanosterol + NADPH = 24-dihydrolanosterol + NADP+
show the reaction diagram
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S-adenosyl-L-methionine + lanosterol = S-adenosyl-L-homocysteine + 24(28)-methylene-24,25-dihydro-lanosterol
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (37 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
lanosterol + NAD(P)+ = lanosterone + NAD(P)H + CO2 + H+
show the reaction diagram
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lanosterol + NADH + H+ + O2 = 4beta-28-hydroxylanosterol + 4alpha-28-hydroxylanosterol + NAD+ + H2O
show the reaction diagram
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lanosterol + NADPH + H+ + O2 = ?
show the reaction diagram
lanosterol + 6 reduced [2Fe-2S] ferredoxin + 3 O2 = lanosterol-26-oate + 6 oxidized [2Fe-2S] ferredoxin + 4 H2O
show the reaction diagram
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oleoyl-CoA + lanosterol = CoA + lanosteryl oleate
show the reaction diagram
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lanosterol + H2O = ?
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (22 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ergosterol + ferrocytochrome b5 + O2 + H+ = lanosterol + ferricyctochrome b5 + H2O
show the reaction diagram
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-
(3S)-2,3-oxidosqualene = lanosterol
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
induction and activation
activation
-

Inhibitor in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
oxidase IC50: 0.00065 mM, reductase IC50: 0.0017 mM
-
inhibits esterification of exogenous cholesterol
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3D Structure of Enzyme-Ligand-Complex (PDB) (3 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (9 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.0023
-
pH 7.5, 30°C, recombinant wild-type enzyme
0.0023
-
pH 7.5, 37°C

KM Value (29 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.0017
-
oxidase IC50: 0.00065 mM, reductase IC50: 0.0017 mM

References & Links

Links to other databases for lanosterol

ChEBI
PubChem
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PubChem