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Enzymic isomerization of DELTA5-3-ketosteroids
1955
Talalay, P.; Wang, V.S.
Biochim. Biophys. Acta
18
300-301
Bioconversion of steroids in vitro by testes from autoimmunized rabbits
1974
Nowotny, E.; Sananez, R.D.; Nattero, G.
Hoppe-Seyler's Z. Physiol. Chem.
355
716-720
Insulin inhibits adrenal 17,20-lyase activity in man
1992
Nestler, J.E.; McClanahan, M.A.; Clore, J.N.; Blackard, W.G.
J. Clin. Endocrinol.
74
362-367
Rainbow trout cytochrome P-450 c17 (17alpha-hydroxylase/17,20-lyase)
1992
Sakai, N.; Tanaka, M.; Adachi, S.; Miller, W.L.; Nagahama, Y.
FEBS Lett.
30
60-64
Isolation and characterization of the mouse P450 17alpha-Hydrolase/C17-20-lyase gene (Cyp 17): Transcriptional regulation of the gene by cyclic adenosine 3¦,5¦-monophosphate in MA-10 Leydig cells
1992
Youngblood, G.L.; Payne, A.
Mol. Endocrinol.
6
927-934
Kinetic analysis of duodenal and testicular cytochrome P450c17 in the rat
1996
Dalla Valle, L.; Ramina, A.; Vianello, S.; Belvedere, P.; Colombo, L.
J. Steroid Biochem. Mol. Biol.
58
577-584
Inhibition of steroid C17(20) lyase with C-17-heteroaryl steroids
1996
Burkhart, J.P.; Gates, C.A.; Laughlin, M.E.; Resvick, R.J.; Peet, N.P.
Bioorg. Med. Chem.
4
1411-1420
Homology modelling of the enzyme P450 17alpha-hydroxylase/17,20-lyase-a taget for prostate cancer chemotherapy-from the crystal structure of P450BM-3
1997
Burke, D.F.; Laughton, C.A.; Neidle, S.
Anticancer Drug Des.
12
113-123
Studies on steroid monooxygenase from Cylindrocarpon radicicola ATCC 11011. Oxygenative lactonization of androstenedione to testololactone
1986
Itagaki, E.
J. Biochem.
99
825-832
Studies on steroid monooxygenase from Cylindrocarpon radicicola ATCC 11011. Purification and characterization
1986
Itagaki, E.
J. Biochem.
99
815-824
Properties of an adrenal cytochrome P-450 (P-45011beta) for the hydroxylations of corticosteroids
1978
Sato, H.; Ashida, N.; Suhara, K.; Itagaki, E.; Takemori, S.; Katagiri, M.
Arch. Biochem. Biophys.
190
307-314
Isolation of multiple forms of indanol dehydrogenase associated with 17-beta-hydroxysteroid dehydrogenase activity from male rabbit
1986
Hara, A.; Kariya, K.; Nakamura, M.; Nakayama, T.; Saweda, H.
Arch. Biochem. Biophys.
249
225-236
Purification and characterization of a novel 17alpha-hydroxysteroid dehydrogenase from an intestinal Eubacterium sp. VPI 12708
1994
De Prada, P.; Setchell, K.D.R.; Hylemon, P.B.
J. Lipid Res.
35
922-929
20alpha-Hydroxysteroid dehydrogenase activity in the rat corpus luteum; a quantitative cytochemical study
1982
Robertson, W.R.; Frost, J.; Hoyer, P.E.; Weinkove, C.
J. Steroid Biochem.
17
237-243
Comparison of the multiple forms of the soluble 3(17)alpha-hydroxysteroid dehydrogenases of female rabbit kidney and liver
1982
Lau, P.C.K.; Layne, D.S.; Williamson, D.G.
J. Biol. Chem.
257
9450-9456
Identification of two dihydrodiol dehydrogenases associated with 3(17)alpha-hydoxysteroid dehydrogenase activity in mouse kidney
1989
Nakagawa, M.; Tsukuda, F.; Nakayama, T.; Matsuura, K.; Hara, A.; Sawada, H.
J. Biochem.
106
633-638
Demonstration of 3alpha(17beta)-hydroxysteroid dehydrogenase distinct from 3alpha-hydroxysteroid dehydrogenase in hamster liver
1990
Ohmura, M.; Hara, A.; Nakagawa, M.; Sawada, H.
Biochem. J.
266
583-589
-
Anreicherung einer 17beta-hydroxysteroid: NAD(P)-Oxydoreduktase aus der Nebenniere der Ratte
1964
Dahm, K.; Breuer, H.
Hoppe-Seyler's Z. Physiol. Chem.
336
63-68
Isolation and characterization of 17beta-hydroxy steroid dehydrogenase from human erythrocytes
1972
Mulder, E.; Lamers-Stahlhofen, G.J.M.; van der Molen, H.J.
Biochem. J.
127
649-659
A 3(17)beta-hydroxysteroid dehydrogenase in rat erythrocytes. Conversion of 5alpha-dihydrotestosterone into 5alpha-androstane-3beta,17beta-diol and purification of the enzyme by affinity chromatography
1974
Heyns, W.; de Moor, P.
Biochim. Biophys. Acta
358
1-13
3(17)beta-Hydroxysteroid dehydrogenase of Pseudomonas testosteroni. A convenient purification and demonstration of multiple molecular forms
1977
Schultz, R.M.; Groman, E.V.; Engel, L.L.
J. Biol. Chem.
252
3775-3783
Dehydroepiandrosterone is a substrate for estradiol 17beta-dehydrogenase from human placenta
1984
Mendoza-Hernandez, G.; Calcagno, M.; Sanchez-Nuncio, H.R.; Diaz-Zagoya, J.C.
Biochem. Biophys. Res. Commun.
119
83-87
On the mitochondrial 17beta-hydroxysteroid dehydrogenase from human endometrium and endometrial carcinoma: characterization and intramitochondrial distribution
1976
Pollow, K.; Luebbert, H.; Pollow, B.
J. Steroid Biochem.
7
45-50
Studies on 17beta-hydroxysteroid dehydrogenase in human endometrium and endometrial carcinoma
1975
Pollow, K.; Luebbert, H.; Jeske, R.; Pollow, B.
Acta Endocrinol.
79
146-156
Kinetic and stereochemical studies on reaction mechanism of mouse liver 17beta-hydroxysteroid dehydrogenases
1987
Hara, A.; Nakayama, T.; Nakagawa, M.; Inoue, Y.; Tanabe, H.; Sawada, H.
J. Biochem.
102
1585-1592
Purification and properties of the soluble 17beta-hydroxysteroid dehydrogenase of rabbit uterus
1979
Pollow, K.; Elger, W.; Hesslinger, H.; Pollow, B.
Z. Naturforsch. C
34
726-737
Purification and properties of oestradiol 17beta-dehydrogenase extracted from cytoplasmic vesicles of porcine endometrial cells
1992
Adamski, J.; Husen, B.; Marks, F.; Jungblut, P.W.
Biochem. J.
288
375-381
Molecular cloning and characterization of mouse estradiol 17beta-dehydrogenase (A-specific), a member of the aldoketoreductase family
1995
Deyashiki, Y.; Ohshima, K.; Nakanishi, M.; Sato, K.; Matsuura, K.; Hara, A.
J. Biol. Chem.
270
10461-10467
Phytoestrogens inhibit human 17beta-hydroxysteroid dehydrogenase type 5
2001
Krazeisen, A.; Breitling, R.; Möller, G.; Adamski, J.
Mol. Cell. Endocrinol.
171
151-162
Testosterone dehydrogenase activity in koala liver: characterization of cofactor and steroid substrate differences
2000
Stupans, I.; Kong, S.; Kirlich, S.; McKinnon, R.A.; Murray, M.
Comp. Biochem. Physiol. B
125
245-250
Characterization and solubization of testosterone 17beta-hydroxysteroid dehydrogenase in human hyperplastic prostate
1993
Carre, J.L.; Quemener, E.; Amet, Y.; Simon, B.; Berthou, F.; Mangin, P.; Floch, H.H.; Abalain, J.H.
J. Steroid Biochem. Mol. Biol.
46
265-267
Expression of human 17beta-hydroxysteroid dehydrogenase in mammalian cells
1992
Dumont, M.; Luu-The, V.; de Lanoit, Y.; Labrie, F.
J. Steroid Biochem. Mol. Biol.
41
605-608
Purification and characterization of 17beta-hydroxysteroid dehydrogenase from Cylindrocarpon radicicola
1988
Itagaki, E.; Iwaya, T.
J. Biochem.
103
1039-1044
Isolation of novel microbiol 3alpha-, 3beta, and 17beta-hydroxysteroid dehydrogenases
1985
Payne, D.W.; Talalay, P.
J. Biol. Chem.
260
13648-13655
Microsomal 17beta-hydroxysteroid dehydrogenase of guinea pig liver: detergent solubilization and a comparison of kinetic and stability properties of bound and solubilized forms
1977
Blomquist, C.H.; Kotts, C.E.; Hakanson, E.Y.
J. Steroid Biochem.
8
193-198
-
Enzyminduktion bei Streptomyces hydrogenans, V. Charakterisierung der Testosteron-17beta-Dehydrogenase und ihre Induktion durch Steroide
1975
Markert, C.; Träger, L.
Hoppe-Seyler's Z. Physiol. Chem.
356
1843-1852
11beta- und 17beta-Hydroxysteroid-dehydrogenase-Aktivitäten der Rattenleber
1973
Ghraf, R.; Raible, M.; Schriefers, H.
Hoppe-Seyler's Z. Physiol. Chem.
354
299-305
-
Separation of a triphosphopyridine nucleotide-specific from a diphosphopyridine nucleotide-specific 17beta-hydroxy-(testosterone)dehydrogenase of guinea pig liver
1960
Endahl, G.L.; Kochakian, C.D.; Hamm, D.
J. Biol. Chem.
235
2793-2796
Some properties of the pyridine nucleotide-specific 17beta-hydroxy steroid dehydrogenases of guinea pig liver
1960
Villee, C.A.; Spencer, J.M.
J. Biol. Chem.
235
3615-3619
Preparation and characterization of the enzyme which converts testosterone to androstendione
1950
Sweat, M.L.; Samuels, L.T.; Lumry, R.
J. Biol. Chem.
185
75-84
Molecular genetics and pathophysiology of 17beta-hydroxysteroid dehydrogenase 3 deficiency
1996
Andersson, S.; Geissler, W.M.; Wu, L.; Davis, D.L.; Grumbach, M.M.; New, M.I.; Schwarz, H.P.; Blethen, S.L.; Mendoca.B.B.; Bloise, W.; Witchel, S.F.; Cutler, G.B.; Griffin, J.E.; Wilson, J.D.; Russell, D.W.
J. Clin. Endocrinol.
81
130-136
Unusual evolution of 11beta- and 17beta-hydroxysteroid dehydrogenases
1995
Baker, M.E.
BioEssays
18
63-70
Male pseudohermaphroditism caused by mutations of testicular 17beta-hydroxysteroid dehydrogenase 3
1994
Geissler, W.M.; Davis, D.L.; Wu, L.; Bradshaw, K.D.; Patel, S.; Mendoca, B.B.; Elliston, K.O.; Wilson, J.D.; Russell, D.W.; Andersson, S.
Nature Genet.
7
34-39
Testicular 17beta-hydroxysteroid dehydrogenas: molecular properties and reaction mechanism
1986
Inano, H.; Tamaoki, B.
Steroids
48
1-26
Guinea-pig liver testosterone 17beta-dehydrogenase (NADP+) and aldehyde reductase exhibit benzene dihydrodiol dehydrogenase activity
1985
Hara, A.; Hayashibara, M.; Nakayama, T.; Hasabe, K.; Usui, s.; Sawada, H.
Biochem. J.
225
177-181
Amino acid composition and immunochemical properties of porcine testicular 17beta-hydroxysteroid dehydrogenase
1980
Inano, H.; Tamaoki, B.; Hamana, K.; Nakagawa, H.
J. Steroid Biochem.
13
287-295
Purification and properties of a new testosterone 17beta-dehydrogenase (NADP+) from guinea-pig liver
1977
Kageura, E.; Toki, S.
Biochem. J.
163
401-407
Relationship between steroids and pyridine nucleotides in the oxido-reduction catalyzed by the 17beta-hydroxysteroid dehydrogenase purified from the porcine testicular microsomal fraction
1975
Inano, H.; Tamaoki, B.
Eur. J. Biochem.
53
319-326
Testicular 17beta-hydroxysteroid dehydrogenase: its distribution, purification and properties
1975
Tamaoki, B-i.; Inano, H.
J. Steroid Biochem.
6
361-363
Purificatition and properties of NADP-dependent 17beta-hydroxysteoid dehydrogenase solubilized from porcine-testicular microsomal fraction
1974
Inano, H.; Tamaoki, B.
Eur. J. Biochem.
44
13-23
On testicular 17beta-hydroxysteroid oxidoreductase product activation of testosterone formation from androstendione in vitro
1973
Oshima, H.; Ochiai, K.
Biochim. Biophys. Acta
306
227-236
Separation of a triphosphopyridine nucleotide-specific from a diphosphopyridine nucleotide-specific 17beta-hydroxy-(testosterone)dehydrogenase of guinea-pig liver
1960
Endahl, G.L.; Kochakian, C.D.; Hamm, D.
J. Biol. Chem.
235
2792-2796
Properties of 5-ene-3beta-hydroxysteroid dehydrogenase in granulosa tissue from the domestic fowl (Gallus domesticus)
1982
Armstrong, D.G.
J. Steroid Biochem.
17
225-230
The engineered, cytosolic form of human type I 3beta-hydroxysteroid dehydrogenase/isomerase: purification, characterization and crystallization
2001
Thomas, J.L.; Mason, J.I.; Blanco, G.; Veisaga, M.L.
J. Mol. Endocrinol.
27
77-83
Purification and characterization of 5alpha-dihydrotestosterone 3beta-hydroxysteroid dehydrogenase from mature pig testicular cytosol
1994
Nakajin, S.; Ishii, A.; Shinoda, M.
Biol. Pharm. Bull.
17
1155-1160
Purification and characterization of NADP+-dependent 3alpha-hydroxysteroid dehydrogenase from mouse liver cytosol
1988
Hara, A.; Inoue, Y.; Nakagawa, M.; Naganeo, F.; Sawada, H.
J. Biochem.
103
1027-1034
Expression cloning and characterization of oxidative 17beta- and 3alpha-hydroxysteroid dehydrogenase from rat and human prostate
1997
Biswas, M.G.; Russel, D.W.
J. Biol. Chem.
272
15959-15966
Expression and characterization of recombinant type 2: 3alpha-hydroxysteroid dehydrogenase (HSD) from human prostate: demonstration of bifunctional 3alpha/17beta-HSD activity and cellular distribution
1997
Lin, H.K.; Jez, J.M.; Schlegel, B.P.; Peehl, D.M.; Pachter, J.A.; Penning, T.M.
Mol. Endocrinol.
11
1971-1984
Characterization of the adrenal cytochrome P450C17 in the hamster, a small animal model for the study of adrenal dehydroepiandrosterone biosynthesis
1997
Cloutier, M.; Fleury, A.; Courtemanche, J.; Ducharme, L.; Mason, J.I.; Lehoux, J.G.
DNA Cell Biol.
16
357-368
Identification of cortisone 5beta-reductase as DELTA4-3-ketosteroid 5beta-reductase
1987
Furuebisu, M.; Deguchi, S.; Okuda, K.
Biochim. Biophys. Acta
912
110-114
Purification and characterization of DELTA 4-3-ketosteroid 5beta-reductase
1984
Okuda, A.; Okuda, K.
J. Biol. Chem.
259
7519-7524
Subcellular localization and properties of mouse adrenal C19-steroid 5beta-reductase
1975
Collins, W.; Cameron, E.H.D.
Biochem. J.
147
165-174
Genomic organization of a human 5beta-reductase and its pseudogene and substrate selectivity of the expressed enzyme
2001
Charbonneau, A.; The, V.L.
Biochim. Biophys. Acta
1517
228-235
The DELTA4-hydrogenases of guinea pig adrenal gland
1960
Brown-Grant, K.; Forchielli, E.; Dorfman, R.I.
J. Biol. Chem.
235
1317-1320
Transformation of testosterone into 17beta-hydroxy-5beta-androstan-3-one by Rana esculenta skeletal muscle
1974
Ozon, R.; Fouchet, C.; Perin, F.
Biochim. Biophys. Acta
348
425-437
-
Some characteristics of the microsomal steroid reductase (5alpha) of rat liver
1960
McGuire, J.S.; Hollis, V.W.; Tomkins, G.M.
J. Biol. Chem.
235
3112-3117
Purification and characterization of 3-ketosteroid-delta 1-dehydrogenase from Nocardia corallina
1990
Itagaki, E.; Wakabayashi, T.; Hatta, T.
Biochim. Biophys. Acta
1038
60-67
Steroid-transforming enzymes from microorganisms. XI. Reversibility of the dehydrogenation reaction of the steroid-1-dehydrogenase from Nocardia opaca
1979
Groh, H.; Komel, R.; Deppmeyer, V.; Atrat, P.; Hörhold, C.
Z. Allg. Mikrobiol.
19
727-730
Bacterial oxidation of steroids. II. Studies on the enzymatic mechanism of ring A dehydrogenation
1959
Levy, H.R.; Talalay, P.
J. Biol. Chem.
234
2014-2021
Isolation of vitamin K2(35) from Nocardia restrictus and Corynebacterium simplex. A natural electron acceptor in microbial steroid ring A dehydrogenations
1978
Abul-Hajj, Y.J.
J. Biol. Chem.
253
2356-2360
Purification and characterization of the 3-ketosteroid-DELTA1-dehydrogenase of Arthrobacter simplex produced in Streptomyces lividans
1995
Choi, K.P.; Molnar, I.; Yamashita, M.; Murooka, Y.
J. Biochem.
117
1043-1049
Molecular cloning, expression in Streptomyces lividans, and analysis of a gene cluster from Arthrobacter simplex encoding 3-ketosteroid-DELTA1-dehydrogenase, 3-ketosteroid-DELTA5-isomerase and a hypothetical regulatory protein
1995
Molnar, I.; Choi, K.P.; Yamashita, M.; Murooka, Y.
Mol. Microbiol.
15
895-905
3-Ketosteroid-DELTA1-dehydrogenase of Rhodococcus rhodochrous: sequencing of the genomic DNA and hyperexpression, purification, and characterization of the recombinant enzyme
1998
Morii, S.; Fujii, C.; Miyoshi, T.; Iwami, M.; Itagaki, E.
J. Biochem.
124
1026-1032
Reduced nicotinamide adenine dinucleotide phosphate delta4-3-ketosteroid 5alpha-oxidoreductase (rat ventral prostate)
1975
Moore, R.J.; Wilson, J.D.
Methods Enzymol.
36A
466-474
Solubilization and partial characterization of rat epididymal delta 4-steroid 5alpha-reductase (cholestenone 5alpha-reductase)
1983
Scheer, H.; Robaire, B.
Biochem. J.
211
65-74
Studies on the biosynthesis of 5alpha-cholestan-3beta-ol 1.Cholestenone of rat liver
1965
Shefer, S.; Hauser, S.; Mosbach, E.H.
J. Biol. Chem.
241
946-952
Inhibition of the activity of basic 5alpha-reductase (type 1) detected in DU 145 cells and expressed in insect cells
1994
Delos, S.; Iehle, C.; Martin, M.; Raynaud, J.P.
J. Steroid Biochem. Mol. Biol.
48
347-352
Cloning, expression and functional characterization of type 1 and type 2 steroid 5alpha-reductase from cynomolgus monkey: comparison with human and rat isoenzymes
1995
Levy, M.A.; Brandt, M.; Sheedy, K.M.; Holt, D.A.; Heaslip, J.I.; Trill, J.J.; Ryan, P.J.; Morris, R.A.; Garrison, L.M.; Bergsma, D.J.
J. Steroid Biochem. Mol. Biol.
52
307-319
Influence of steroid hormones on 5alpha-reductase activity in female and male genital skin fibroblats in culture
1993
Beckmann, M.W.; Wieacker, P.; Dereser, M.M.; Flecken, U.; Breckwoldt, M.
Acta Endocrinol.
128
161-167
Mechanisms of steroid oxidation by microorganisms. XI. Enzymatic cleavage of the pregnane side chain
1966
Rahim, M.A.; Sih, C.J.
J. Biol. Chem.
241
3615-3623
cDNA cloning, heterologous expression, and characterization of mouse CYP2G1, an olfactory-specific steroid hydroxylase
1997
Hua, Z.; Zhang, Q.; Su, T.; Lipinskas, T.W.; Ding, X.
Arch. Biochem. Biophys.
340
208-214
-
9alpha-Hydroxylation of 4-androstene-3,17-dione by gel-entrapped Corynebacterium sp. cells
1983
Sonomoto K.; Usuin N.; Tanaka A.; Fukui S.
Eur. J. Appl. Microbiol. Biotechnol.
17
203-210
-
The inducibility of 9alpha-steroid hydroxylating activity in resting Rhodococcus sp. cells
1997
Mutafov, S.; Angelova, B.; Avramova, T.; Boyadjieva, L.; Dimova, I.
Process Biotechnol.
32
585-589
Enzymatic formation of testololactone
1963
Prairie, R.L.; Talalay, P.
Biochemistry
2
203-208
Acyl CoA:cholesterol acyl transferase activity in human placental microsomes: inhibition by progesterone
1980
Simpson, E.R.; Burkhart, M.F.
Arch. Biochem. Biophys.
200
79-85
Roles of active site aromatic residues in catalysis by ketosteroid isomerase from Pseudomonas putida biotype B
1999
Kim, D.H.; Nam, G.H.; Jang, D.S.; Choi, G.; Joo, S.; Kim, J.S.; Oh, B.H.; Choi, K.Y.
Biochemistry
38
13810-13819
Catalytic activity of the D38A mutant of 3-oxo-DELTA 5-steroid isomerase: recruitment of aspartate-99 as the base
2000
Henot, F.; Pollack, R.M.
Biochemistry
39
3351-3359
Contribution of the hydrogen-bond network involving a tyrosine triad in the active site to the structure and function of a highly proficient ketosteroid isomerase from Pseudomonas putida biotype B
2000
Kim, D.H.; Jang, D.S.; Nam, G.H.; Choi, G.; Kim, J.S.; Ha, N.C.; Kim, M.S.; Oh, B.H.; Choi, K.Y.
Biochemistry
39
4581-4589
Asp-99 donates a hydrogen bond not to Tyr-14 but to the steroid directly in the catalytic mechanism of DELTA 5-3-ketosteroid isomerase from Pseudomonas putida biotype B
2000
Choi, G.; Ha, N.C.; Kim, S.W.; Kim, D.H.; Park, S.; Oh, B.H.; Choi, K.Y.
Biochemistry
39
903-909
Pseudoreversion of the catalytic activity of Y14F by the additional substitution(s) of tyrosine with phenylalanine in the hydrogen bond network of DELTA 5-3-ketosteroid isomerase from Pseudomonas putida biotype B
2001
Choi, G.; Ha, N.C.; Kim, M.S.; Hong, B.H.; Oh, B.H.; Choi, K.Y.
Biochemistry
40
6828-6835
Contribution of conserved amino acids at the dimeric interface to the conformational stability and the structural integrity of the active site in ketosteroid isomerase from Pseudomonas putida biotype B
2003
Nam, G.H.; Kim, D.H.; Ha, N.C.; Jang do, S.; Yun, Y.S.; Hong, B.H.; Oh, B.H.; Choi, K.Y.
J. Biochem.
134
101-110
Origin of the different pH activity profile in two homologous ketosteroid isomerases
2003
Yun, Y.S.; Lee, T.H.; Nam, G.H.; Jang, D.S.; Shin, S.; Oh, B.H.; Choi, K.Y.
J. Biol. Chem.
278
28229-28236
Structure/function relationships responsible for coenzyme specificity and the isomerase activity of human type 1 3 beta-hydroxysteroid dehydrogenase/isomerase
2003
Thomas, J.L.; Duax, W.L.; Addlagatta, A.; Brandt, S.; Fuller, R.R.; Norris, W.
J. Biol. Chem.
278
35483-35490
Specificity of human alcohol dehydrogenase 1C*2 (gamma2gamma2) for steroids and simulation of the uncompetitive inhibition of ethanol metabolism
2003
Plapp, B.V.; Berst, K.B.
Chem. Biol. Interact.
143-144
183-193
Estrogen metabolism in human colorectal cancer cells
2002
Fiorelli, G.; Picariello, L.; Martineti, V.; Tognarini, I.; Tonelli, F.; Brandi, M.L.
J. Steroid Biochem. Mol. Biol.
81
281-289
Characterisation of estrogenic 17beta-hydroxysteroid dehydrogenase (17beta-HSD) activity in the human brain
2003
Steckelbroeck, S.; Watzka, M.; Reissinger, A.; Wegener-Toper, P.; Bidlingmaier, F.; Bliesener, N.; Hans, V.H.; Clusmann, H.; Ludwig, M.; Siekmann, L.; Klingmuller, D.
J. Steroid Biochem. Mol. Biol.
86
79-92
Molecular and functional characterization of the kstD2 gene of Rhodococcus erythropolis SQ1 encoding a second 3-ketosteroid DELTA(1)-dehydrogenase isoenzyme
2002
van der Geize, R.; Hessels, G.I.; Dijkhuizen, L.
Microbiology
148
3285-3292
Human 17beta-hydroxysteroid dehydrogenases types 1, 2, and 3 catalyze bi-directional equilibrium reactions, rather than unidirectional metabolism, in HEK-293 cells
2004
Khan, N.; Sharma, K.K.; Andersson, S.; Auchus, R.J.
Arch. Biochem. Biophys.
429
50-59
cyp7b1 catalyses the 7alpha-hydroxylation of dehydroepiandrosterone and 25-hydroxycholesterol in rat prostate
2001
Martin, C.; Bean, R.; Rose, K.; Habib, F.; Seckl, J.
Biochem. J.
355
509-515
Amino acid substitution of arginine 80 in 17beta-hydroxysteroid dehydrogenase type 3 and its effect on NADPH cofactor binding and oxidation/reduction kinetics
2002
McKeever, B.M.; Hawkins, B.K.; Geissler, W.M.; Wu, L.; Sheridan, R.P.; Mosley, R.T.; Andersson, S.
Biochim. Biophys. Acta
1601
29-37
Inhibitors of 17beta-hydroxysteroid dehydrogenases
2003
Poirier, D.
Curr. Med. Chem.
10
453-477
Some coumarins and triphenylethene derivatives as inhibitors of human testes microsomal 17beta-hydroxysteroid dehydrogenase (17beta-HSD type 3): further studies with tamoxifen on the rat testes microsomal enzyme
2002
le Lain, R.; Barrell, K.J.; Saeed, G.S.; Nicholls, P.J.; Simons, C.; Kirby, A.; Smith, H.J.
J. Enzyme Inhib. Med. Chem.
17
93-100
Regulation of phase I and phase II steroid metabolism enzymes by PPARa activators
2004
Fan, L.Q.; You, L.; Brown-Borg, H.; Brown, S.; Edwards, R.J.; Corton, J.C.
Toxicology
204
109-121
Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a series of 4-hydroxyphenyl ketones as potential inhibitors of 17beta-hydroxysteroid dehydrogenase type 3 (17beta-HSD3)
2006
Lota, R.K.; Dhanani, S.; Owen, C.P.; Ahmed, S.
Bioorg. Med. Chem. Lett.
16
4519-4522
Characterization of 17alpha-hydroxysteroid dehydrogenase activity (17alpha-HSD) and its involvement in the biosynthesis of epitestosterone
2005
Bellemare, V.; Faucher, F.; Breton, R.; Luu-The, V.
BMC Biochem.
6
12
Androsterone 3alpha-ether-3beta-substituted and androsterone 3beta-substituted derivatives as inhibitors of type 3 17beta-hydroxysteroid dehydrogenase: chemical synthesis and structure-activity relationship
2005
Tchedam Ngatcha, B.; Luu-The, V.; Labrie, F.; Poirier, D.
J. Med. Chem.
48
5257-5268
Androgen metabolism via 17beta-hydroxysteroid dehydrogenase type 3 in mammalian and non-mammalian vertebrates: comparison of the human and the zebrafish enzyme
2005
Mindnich, R.; Haller, F.; Halbach, F.; Moeller, G.; Hrabe de Angelis, M.; Adamski, J.
J. Mol. Endocrinol.
35
305-316
3beta-Alkyl-androsterones as inhibitors of type 3 17beta-hydroxysteroid dehydrogenase: inhibitory potency in intact cells, selectivity towards isoforms 1, 2, 5 and 7, binding affinity for steroid receptors, and proliferative/antiproliferative activities on AR+ and ER+ cell lines
2006
Ngatcha, B.T.; Laplante, Y.; Labrie, F.; Luu-The, V.; Poirier, D.
Mol. Cell. Endocrinol.
248
225-232
Characterization of type 12 17beta-hydroxysteroid dehydrogenase, an isoform of type 3 17beta-hydroxysteroid dehydrogenase responsible for estradiol formation in women
2006
Luu-The, V.; Tremblay, P.; Labrie, F.
Mol. Endocrinol.
20
437-443
Identification of a novel series of tetrahydrodibenzazocines as inhibitors of 17beta-hydroxysteroid dehydrogenase type 3
2006
Fink, B.E.; Gavai, A.V.; Tokarski, J.S.; Goyal, B.; Misra, R.; Xiao, H.; Kimball, S.D.; Han, W.; Norris, D.; Spires, T.E.; You, D.; Gottardis, M.M.; Lorenzi, M.V.; Vite, G.D.
Bioorg. Med. Chem. Lett.
16
1532-1536
Reductase activity of 17beta-hydroxysteroid oxidoreductase in prostatic tumors of different histological structure
2005
Degtyar, V.G.; Babkina, T.V.; Kazantseva, I.A.; Morozov, A.P.; Trapeznikova, M.F.; Kushlinskii, N.E.
Bull. Exp. Biol. Med.
139
715-717
Activities of 3beta-HSD and aromatase in slices of developing and adult zebra finch brain
2006
Tam, H.; Schlinger, B.A.
Gen. Comp. Endocrinol.
150
26-33
Cloning, expression and characterization of three types of 17beta-hydroxysteroid dehydrogenases from the Nile tilapia, Oreochromis niloticus
2005
Zhou, L.Y.; Wang, D.S.; Senthilkumaran, B.; Yoshikuni, M.; Shibata, Y.; Kobayashi, T.; Sudhakumari, C.C.; Nagahama, Y.
J. Mol. Endocrinol.
35
103-116
5alpha-Reductase activity in Lycopersicon esculentum: cloning and functional characterization of LeDET2 and evidence of the presence of two isoenzymes
2005
Rosati, F.; Bardazzi, I.; De Blasi, P.; Simi, L.; Scarpi, D.; Guarna, A.; Serio, M.; Racchi, M.L.; Danza, G.
J. Steroid Biochem. Mol. Biol.
96
287-299
Cinnamic acids as new inhibitors of 17beta-hydroxysteroid dehydrogenase type 5 (AKR1C3)
2006
Brozic, P.; Golob, B.; Gomboc, N.; Rizner, T.L.; Gobec, S.
Mol. Cell. Endocrinol.
248
233-235
Structure and function of human 17beta-hydroxysteroid dehydrogenases
2006
Lukacik, P.; Kavanagh, K.L.; Oppermann, U.
Mol. Cell. Endocrinol.
248
61-71
Molecular cloning and heterologous expression of progesterone 5beta-reductase from Digitalis lanata Ehrh.
2006
Herl, V.; Fischer, G.; Müller-Uri, F.; Kreis, W.
Phytochemistry
67
225-231
Molecular cloning and expression of progesterone 5beta-reductase (5beta-POR) from Isoplexis canariensis
2006
Herl, V.; Fischer, G.; Bötsch, R.; Müller-Uri, F.; Kreis, W.
Planta Med.
72
1163-1165
Structure of 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) holoenzyme from an orthorhombic crystal form: an insight into the bifunctionality of the enzyme
2007
Dhagat, U.; Carbone, V.; Chung, R.P.; Schulze-Briese, C.; Endo, S.; Hara, A.; El-Kabbani, O.
Acta Crystallogr. Sect. F
63
825-830
Rat NAD+-dependent 3alpha-hydroxysteroid dehydrogenase (AKR1C17): a member of the aldo-keto reductase family highly expressed in kidney cytosol
2007
Sanai, M.; Endo, S.; Matsunaga, T.; Ishikura, S.; Tajima, K.; El-Kabbani, O.; Hara, A.
Arch. Biochem. Biophys.
464
122-129
3-Keto-5alpha-steroid DELTA(1)-dehydrogenase from Rhodococcus erythropolis SQ1 and its orthologue in Mycobacterium tuberculosis H37Rv are highly specific enzymes that function in cholesterol catabolism
2008
Knol, J.; Bodewits, K.; Hessels, G.I.; Dijkhuizen, L.; van der Geize, R.
Biochem. J.
410
339-346
Mouse N-acetyltransferase type 2, the homologue of human N-acetyltransferase type 1
2008
Kawamura, A.; Westwood, I.; Wakefield, L.; Long, H.; Zhang, N.; Walters, K.; Redfield, C.; Sim, E.
Biochem. Pharmacol.
75
1550-1560
An indomethacin analogue, N-(4-chlorobenzoyl)-melatonin, is a selective inhibitor of aldo-keto reductase 1C3 (type 2 3alpha-HSD, type 5 17beta-HSD, and prostaglandin F synthase), a potential target for the treatment of hormone dependent and hormone independent malignancies
2008
Byrns, M.C.; Steckelbroeck, S.; Penning, T.M.
Biochem. Pharmacol.
75
484-493
Steroidal lactones as inhibitors of 17beta-hydroxysteroid dehydrogenase type 5: Chemical synthesis, enzyme inhibitory activity, and assessment of estrogenic and androgenic activities
2008
Bydal, P.; Luu-The, V.; Labrie, F.; Poirier, D.
Eur. J. Med. Chem.
44
632-644
Co-expression of human ABCG5 and ABCG8 in insect cells generates an androstane stimulated membrane ATPase activity
2006
Mueller, M.; Klein, I.; Kopacsi, S.; Remaley, A.T.; Rajnavoelgyi, E.; Sarkadi, B.; Varadi, A.
FEBS Lett.
580
6139-6144
Rational design of novel mutants of fungal 17beta-hydroxysteroid dehydrogenase
2007
Kristan, K.; Stojan, J.; Adamski, J.; Lanisnik Rizner, T.
J. Biotechnol.
129
123-130
Differential androgen and estrogen substrates specificity in the mouse and primates type 12 17beta-hydroxysteroid dehydrogenase
2007
Blanchard, P.G.; Luu-The, V.
J. Endocrinol.
194
449-455
Expression of ksdD gene encoding 3-ketosteroid-DELTA1-dehydrogenase from Arthrobacter simplex in Bacillus subtilis
2007
Li, Y.; Lu, F.; Sun, T.; Du, L.
Lett. Appl. Microbiol.
44
563-568
Activation of androgens by hydroxysteroid (17beta) dehydrogenase 1 in vivo as a cause of prenatal masculinization and ovarian benign serous cystadenomas
2007
Saloniemi, T.; Lamminen, T.; Huhtinen, K.; Welsh, M.; Saunders, P.; Kujari, H.; Poutanen, M.
Mol. Endocrinol.
21
2627-2636
Biotechnological approach to the synthesis of 9alpha-hydroxylated steroids
2007
Arnell, R.; Johannisson, R.; Lindholm, J.; Fornstedt, T.; Ersson, B.; Ballagi, A.; Caldwell, K.
Prep. Biochem. Biotechnol.
37
309-321
Structure of the G225P/G226P mutant of mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) ternary complex: implications for the binding of inhibitor and substrate
2009
Dhagat, U.; Endo, S.; Mamiya, H.; Hara, A.; El-Kabbani, O.
Acta Crystallogr. Sect. D
65
257-265
Kinetic studies of AKR1B10, human aldose reductase-like protein: endogenous substrates and inhibition by steroids
2009
Endo, S.; Matsunaga, T.; Mamiya, H.; Ohta, C.; Soda, M.; Kitade, Y.; Tajima, K.; Zhao, H.T.; El-Kabbani, O.; Hara, A.
Arch. Biochem. Biophys.
487
1-9
Comparison of sex-steroid synthesis between neonatal and adult rat hippocampus
2009
Higo, S.; Hojo, Y.; Ishii, H.; Kominami, T.; Nakajima, K.; Poirier, D.; Kimoto, T.; Kawato, S.
Biochem. Biophys. Res. Commun.
385
62-66
Two homologous fungal carbonyl reductases with different substrate specificities
2009
Kristan, K.; Brunskole, M.; Stojan, J.; Rizner, T.L.
Chem. Biol. Interact.
178
295-302
Characterization of a cytochrome P-450-dependent steroid hydroxylase system present in Bacillus megaterium
1976
Berg, A.; Gustafsson, J.A.; Ingelman-Sundberg, M.
J. Biol. Chem.
251
2831-2838
Effects of corticosterone deficiency and its replacement on Leydig cell steroidogenesis
2008
Parthasarathy, C.; Balasubramanian, K.
J. Cell. Biochem.
104
1671-1683
The (+)- and (-)-gossypols potently inhibit both 3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase 3 in human and rat testes
2009
Hu, G.X.; Zhou, H.Y.; Li, X.W.; Chen, B.B.; Xiao, Y.C.; Lian, Q.Q.; Liang, G.; Kim, H.H.; Zheng, Z.Q.; Hardy, D.O.; Ge, R.S.
J. Steroid Biochem. Mol. Biol.
115
14-19
Development of hormone-dependent prostate cancer models for the evaluation of inhibitors of 17beta-hydroxysteroid dehydrogenase type 3
2009
Day, J.M.; Tutill, H.J.; Foster, P.A.; Bailey, H.V.; Heaton, W.B.; Sharland, C.M.; Vicker, N.; Potter, B.V.; Purohit, A.; Reed, M.J.
Mol. Cell. Endocrinol.
301
251-258
Crystal structures of human Delta4-3-ketosteroid 5beta-reductase (AKR1D1) reveal the presence of an alternative binding site responsible for substrate inhibition
2008
Faucher, F.; Cantin, L.; Luu-The, V.; Labrie, F.; Breton, R.
Biochemistry
47
13537-13546
Emergence of a novel highly specific and catalytically efficient enzyme from a naturally promiscuous glutathione transferase
2008
Blikstad, C.; Shokeer, A.; Kurtovic, S.; Mannervik, B.
Biochim. Biophys. Acta
1780
1458-1463
Studies on a Tyr residue critical for the binding of coenzyme and substrate in mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21): structure of the Y224D mutant enzyme
2010
Dhagat, U.; Endo, S.; Mamiya, H.; Hara, A.; El-Kabbani, O.
Acta Crystallogr. Sect. D
66
198-204
The UV-filter benzophenone-1 inhibits 17beta-hydroxysteroid dehydrogenase type 3: Virtual screening as a strategy to identify potential endocrine disrupting chemicals
2010
Nashev, L.G.; Schuster, D.; Laggner, C.; Sodha, S.; Langer, T.; Wolber, G.; Odermatt, A.
Biochem. Pharmacol.
79
1189-1199
Inhibition of 3beta- and 17beta-hydroxysteroid dehydrogenase activities in rat Leydig cells by perfluorooctane acid
2010
Zhao, B.; Chu, Y.; Hardy, D.O.; Li, X.K.; Ge, R.S.
J. Steroid Biochem. Mol. Biol.
118
13-17
Aldo-keto reductase 1C3 expression in MCF-7 cells reveals roles in steroid hormone and prostaglandin metabolism that may explain its over-expression in breast cancer
2010
Byrns, M.C.; Duan, L.; Lee, S.H.; Blair, I.A.; Penning, T.M.
J. Steroid Biochem. Mol. Biol.
118
177-187
An overview on 5alpha-reductase inhibitors
2010
Aggarwal, S.; Thareja, S.; Verma, A.; Bhardwaj, T.R.; Kumar, M.
Steroids
75
109-153
Characterization of a second Rhodococcus erythropolis SQ1 3-ketosteroid 9alpha-hydroxylase activity comprising a terminal oxygenase homologue, KshA2, active with oxygenase-reductase component KshB
2008
Van Der Geize, R.; Hessels, G.; Nienhuis-Kuiper, M.; Dijkhuizen, L.
Appl. Environ. Microbiol.
74
7197-7203
Multiplicity of 3-ketosteroid-9alpha-hydroxylase enzymes in Rhodococcus rhodochrous DSM43269 for specific degradation of different classes of steroids
2011
Petrusma, M.; Hessels, G.; Dijkhuizen, L.; van der Geize, R.
J. Bacteriol.
193
3931-3940
Structural features in the KshA terminal oxygenase protein that determine substrate preference of 3-ketosteroid 9alpha-hydroxylase enzymes
2012
Petrusma, M.; Dijkhuizen, L.; van Der Geize, R.
J. Bacteriol.
194
115-121
Characterization of 3-ketosteroid 9alpha-hydroxylase, a Rieske oxygenase in the cholesterol degradation pathway of Mycobacterium tuberculosis
2009
Capyk, J.; DAngelo, I.; Strynadka, N.; Eltis, L.
J. Biol. Chem.
284
9937-9946
Activity of 3-ketosteroid 9alpha-hydroxylase (KshAB) indicates cholesterol side chain and ring degradation occur simultaneously in Mycobacterium tuberculosis
2011
Capyk, J.; Casabon, I.; Gruninger, R.; Strynadka, N.; Eltis, L.
J. Biol. Chem.
286
40717-40724
Molecular and functional characterization of kshA and kshB, encoding two components of 3-ketosteroid 9alpha-hydroxylase, a class IA monooxygenase, in Rhodococcus erythropolis strain SQ1
2002
Van Der Geize, R.; Hessels, G.; Van Gerwen, R.; Van Der Meijden, P.; Dijkhuizen, L.
Mol. Microbiol.
45
1007-1018
Purification, crystallization and preliminary X-ray crystallographic analysis of 3-ketosteroid DELTA1-dehydrogenase from Rhodococcus erythropolis SQ1
2012
Rohman, A.; van Oosterwijk, N.; Dijkstra, B.W.
Acta Crystallogr. Sect. F
68
551-556
Inactivation and augmentation of the primary 3-ketosteroid-DELTA1-dehydrogenase in Mycobacterium neoaurum NwIB-01: biotransformation of soybean phytosterols to 4-androstene-3,17-dione or 1,4-androstadiene-3,17-dione
2010
Wei, W.; Wang, F.Q.; Fan, S.Y.; Wei, D.Z.
Appl. Environ. Microbiol.
76
4578-4582
Characterization and application of fusidane antibiotic biosynethsis enzyme 3-ketosteroid-DELTA1-dehydrogenase in steroid transformation
2012
Chen, M.M.; Wang, F.Q.; Lin, L.C.; Yao, K.; Wei, D.Z.
Appl. Microbiol. Biotechnol.
96
133-142
Inhibition of aromatase cytochrome P-450 (estrogen synthetase) by derivatives of alpha-naphthoflavone
1986
Kellis, J.T.; Nesnow, S.; Vickery, L.E.
Biochem. Pharmacol.
35
2887-2891
The involvement of human placental microsomal cytochrome P-450 in aromatization
1974
Thompson, E.A.Jr.; Siiteri, P.K.
J. Biol. Chem.
249
5373-5378
Mechanism of estrogen biosynthesis. Participation of multiple enzyme sites in placental aromatase hydroxylations
1981
Fishman, J.; Goto, J.
J. Biol. Chem.
256
4466-4471
Purification and characterization of human placental aromatase cytochrome P-450
1987
Kellis, J.T.; Vickery, L.E.
J. Biol. Chem.
262
4413-20
Bioconversion of 4-androstene-3,17-dione to androst-1,4-diene-3,17-dione by recombinant Bacillus subtilis expressing ksdd gene encoding 3-ketosteroid-DELTA1-dehydrogenase from Mycobacterium neoaurum JC-12
2013
Zhang, W.; Shao, M.; Rao, Z.; Xu, M.; Zhang, X.; Yang, T.; Li, H.; Xu, Z.
J. Steroid Biochem. Mol. Biol.
135
36-42
Identification and engineering of cholesterol oxidases involved in the initial step of sterols catabolism in Mycobacterium neoaurum
2013
Yao, K.; Wang, F.; Zhang, H.; Wei, D.
Metab. Eng.
15
75-87
Structural insights into aldosterone synthase substrate specificity and targeted inhibition
2013
Strushkevich, N.; Gilep, A.A.; Shen, L.; Arrowsmith, C.H.; Edwards, A.M.; Usanov, S.A.; Park, H.W.
Mol. Endocrinol.
27
315-324
Substrate specificity and inhibitor analyses of human steroid 5beta-reductase (AKR1D1)
2011
Chen, M.; Drury, J.E.; Penning, T.M.
Steroids
76
484-490
Role of 11beta-OH-C(19) and C(21) steroids in the coupling of 11beta-HSD1 and 17beta-HSD3 in regulation of testosterone biosynthesis in rat Leydig cells
2011
Latif, S.A.; Shen, M.; Ge, R.S.; Sottas, C.M.; Hardy, M.P.; Morris, D.J.
Steroids
76
682-689
7-Benzyloxyquinoline oxidation by P450eryF A245T: finding of a new fluorescent substrate probe
2002
Khan, K.K.; Halpert, J.R.
Chem. Res. Toxicol.
15
806-814
Scrutiny of electrochemically-driven electrocatalysis of C-19 steroid 1alpha-hydroxylase (CYP260A1) from Sorangium cellulosum So ce56
2016
Kuzikov, A.V.; Masamrekh, R.A.; Khatri, Y.; Zavialova, M.G.; Bernhardt, R.; Archakov, A.I.; Shumyantseva, V.V.
Anal. Biochem.
513
28-35
Substrate hunting for the myxobacterial CYP260A1 revealed new 1alpha-hydroxylated products from C-19 steroids
2016
Khatri, Y.; Ringle, M.; Lisurek, M.; von Kries, J.P.; Zapp, J.; Bernhardt, R.
Chembiochem
17
90-101
Substrate specificity and inhibitor sensitivity of rabbit 20alpha-hydroxysteroid dehydrogenase
2013
Endo, S.; Arai, Y.; Hara, A.; Kitade, Y.; Bunai, Y.; El-Kabbani, O.; Matsunaga, T.
Biol. Pharm. Bull.
36
1514-1518
Molecular and biochemical characterisation of human short-chain dehydrogenase/reductase member 3 (DHRS3)
2015
Lundova, T.; Zemanova, L.; Malcekova, B.; Skarka, A.; Stambergova, H.; Havrankova, J.; Safr, M.; Wsol, V.
Chem. Biol. Interact.
234
178-187
Aldo-keto Reductase 1B15 (AKR1B15): a mitochondrial human aldo-keto reductase with activity toward steroids and 3-keto-acyl-CoA conjugates
2015
Weber, S.; Salabei, J.K.; Moeller, G.; Kremmer, E.; Bhatnagar, A.; Adamski, J.; Barski, O.A.
J. Biol. Chem.
290
6531-6545
In vitro and in vivo evaluation of a 3beta-androsterone derivative as inhibitor of 17beta-hydroxysteroid dehydrogenase type 3
2014
Roy, J.; Fournier, M.A.; Maltais, R.; Kenmogne, L.C.; Poirier, D.
J. Steroid Biochem. Mol. Biol.
141
44-51
Crystal structure and site-directed mutagenesis of 3-ketosteroid Delta1-dehydrogenase from Rhodococcus erythropolis SQ1 explain its catalytic mechanism
2013
Rohman, A.; van Oosterwijk, N.; Thunnissen, A.M.; Dijkstra, B.W.
J. Biol. Chem.
288
35559-35568
A mutant form of 3-ketosteroid-Delta(1)-dehydrogenase gives altered androst-1,4-diene-3, 17-dione/androst-4-ene-3,17-dione molar ratios in steroid biotransformations by Mycobacterium neoaurum ST-095
2016
Shao, M.; Zhang, X.; Rao, Z.; Xu, M.; Yang, T.; Li, H.; Xu, Z.; Yang, S.
J. Ind. Microbiol. Biotechnol.
43
691-701
Characterization and engineering of 3-ketosteroid-Delta1-dehydrogenase and 3-ketosteroid-9alpha-hydroxylase in Mycobacterium neoaurum ATCC 25795 to produce 9alpha-hydroxy-4-androstene-3,17-dione through the catabolism of sterols
2014
Yao, K.; Xu, L.Q.; Wang, F.Q.; Wei, D.Z.
Metab. Eng.
24
181-191
Functional differentiation of 3-ketosteroid Delta(1)-dehydrogenase isozymes in Rhodococcus ruber strain Chol-4
2017
Guevara, G.; Fernandez de Las Heras, L.; Perera, J.; Navarro Llorens, J.M.
Microb. Cell Fact.
16
42
3-Ketosteroid 9alpha-hydroxylase enzymes Rieske non-heme monooxygenases essential for bacterial steroid degradation
2014
Petrusma, M.; van der Geize, R.; Dijkhuizen, L.
Antonie van Leeuwenhoek
106
157-172
Comparison of CYP106A1 and CYP106A2 from Bacillus megaterium - identification of a novel 11-oxidase activity
2015
Kiss, F.M.; Schmitz, D.; Zapp, J.; Dier, T.K.; Volmer, D.A.; Bernhardt, R.
Appl. Microbiol. Biotechnol.
99
8495-8514
Aromatase activity in brain and ovary seasonal variations correlated with circannual gonadal cycle in the catfish, Heteropneustes fossilis
2014
Aggarwal, N.; Goswami, S.V.; Khandelwal, P.; Sehgal, N.
Indian J. Exp. Biol.
52
527-537
Substrate specificities and conformational flexibility of 3-ketosteroid 9alpha-hydroxylases
2014
Penfield, J.S.; Worrall, L.J.; Strynadka, N.C.; Eltis, L.D.
J. Biol. Chem.
289
25523-25536
Evidence for an elevated aspartate pK(a) in the active site of human aromatase
2015
Di Nardo, G.; Breitner, M.; Bandino, A.; Ghosh, D.; Jennings, G.K.; Hackett, J.C.; Gilardi, G.
J. Biol. Chem.
290
1186-1196
-
Biotransformation of androst-4-ene-3,17-dione by some fungi
2017
Yildirim, K.; Kuru, A.; Keskin, E.; Salihoglu, A.; Bukum, N.
J. Chem. Res.
41
594-597
Crystal structure and functional characterization of a cytochrome P450 (BaCYP106A2) from Bacillus sp. PAMC 23377
2017
Kim, K.H.; Lee, C.W.; Dangi, B.; Park, S.H.; Park, H.; Oh, T.J.; Lee, J.H.
J. Microbiol. Biotechnol.
27
1472-1482
Single or multiple access channels to the CYP450s active site? An answer from free energy simulations of the human aromatase enzyme
2017
Magistrato, A.; Sgrignani, J.; Krause, R.; Cavalli, A.
J. Phys. Chem. Lett.
8
2036-2042
Evolutionary comparisons predict that dimerization of human cytochrome P450 aromatase increases its enzymatic activity and efficiency
2015
Martin, L.L.; Holien, J.K.; Mizrachi, D.; Corbin, C.J.; Conley, A.J.; Parker, M.W.; Rodgers, R.J.
J. Steroid Biochem. Mol. Biol.
154
294-301
Functional characterization of 3-ketosteroid 9alpha-hydroxylases in Rhodococcus ruber strain chol-4
2017
Guevara, G.; Heras, L.F.L.; Perera, J.; Llorens, J.M.N.
J. Steroid Biochem. Mol. Biol.
172
176-187
Efficient 9alpha-hydroxy-4-androstene-3,17-dione production by engineered Bacillus subtilis co-expressing Mycobacterium neoaurum 3-ketosteroid 9alpha-hydroxylase and B. subtilis glucose 1-dehydrogenase with NADH regeneration
2016
Zhang, X.; Rao, Z.; Zhang, L.; Xu, M.; Yang, T.
SpringerPlus
5
1207
DELTA4-3-ketosteroids as a new class of substrates for the cytosolic sulfotransferases
2017
Hashiguchi, T.; Kurogi, K.; Shimohira, T.; Teramoto, T.; Liu, M.C.; Suiko, M.; Sakakibara, Y.
Biochim. Biophys. Acta
1861
2883-2890
The curcumin derivative, H10, suppresses hormone-dependent prostate cancer by inhibiting 17beta-hydroxysteroid dehydrogenase type 3
2020
Cheng, Y.; Yang, Y.; Wu, Y.; Wang, W.; Xiao, L.; Zhang, Y.; Tang, J.; Huang, Y.D.; Zhang, S.; Xiang, Q.
Front. Pharmacol.
11
637
Evaluation of 17beta-hydroxysteroid dehydrogenase activity using androgen receptor-mediated transactivation
2020
Yazawa, T.; Imamichi, Y.; Uwada, J.; Sekiguchi, T.; Mikami, D.; Kitano, T.; Ida, T.; Sato, T.; Nemoto, T.; Nagata, S.; Islam Khan, M.R.; Takahashi, S.; Ushikubi, F.; Suzuki, N.; Umezawa, A.; Taniguchi, T.
J. Steroid Biochem. Mol. Biol.
196
105493
Role of human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C3) in the extrahepatic metabolism of the steroidal aromatase inactivator Formestane
2020
Wan, R.; Kong, X.; Yang, Y.; Tao, S.; Chen, Y.; Teichmann, A.T.; Wieland, F.H.
J. Steroid Biochem. Mol. Biol.
198
105527
Engineering Mycobacterium smegmatis for testosterone production
2017
Fernández-Cabezón, L.; Galán, B.; GarcÃa, J.
Microb. Biotechnol.
10
151-161
Development of 17beta-hydroxysteroid dehydrogenase type 3 as a target in hormone-dependent prostate cancer therapy
2017
Ning, X.; Yang, Y.; Deng, H.; Zhang, Q.; Huang, Y.; Su, Z.; Fu, Y.; Xiang, Q.; Zhang, S.
Steroids
121
10-16
Characterization of new recombinant 3-ketosteroid-DELTA1-dehydrogenases for the biotransformation of steroids
2017
Wang, X.; Feng, J.; Zhang, D.; Wu, Q.; Zhu, D.; Ma, Y.
Appl. Microbiol. Biotechnol.
101
6049-6060
Purification, characterization, and application of a high activity 3-ketosteroid-DELTA1-dehydrogenase from Mycobacterium neoaurum DSM 1381
2019
Zhang, R.; Xu, X.; Cao, H.; Yuan, C.; Yuminaga, Y.; Zhao, S.; Shi, J.; Zhang, B.
Appl. Microbiol. Biotechnol.
103
6605-6616
Human and murine steroid 5beta-reductases (AKR1D1 and AKR1D4) insights into the role of the catalytic glutamic acid
2019
Chen, M.; Wangtrakuldee, P.; Zang, T.; Duan, L.; Gathercole, L.L.; Tomlinson, J.W.; Penning, T.M.
Chem. Biol. Interact.
305
163-170
Expression in Escherichia Coli, purification, and functional reconstitution of human steroid 5alpha-reductases
2020
Peng, H.M.; Valentin-Goyco, J.; Im, S.C.; Han, B.; Liu, J.; Qiao, J.; Auchus, R.J.
Endocrinology
161
bqaa117
Identification of key sites determining the cofactor specificity and improvement of catalytic activity of a steroid 5beta-reductase from Capsella rubella
2020
Li, Y.; Pan, H.; Chang, Y.; Dong, N.; Zou, L.; Liang, P.; Tian, W.; Chang, Z.
Enzyme Microb. Technol.
134
109483
Aerobic catabolism of sterols by microorganisms key enzymes that open the 3-ketosteroid nucleus
2019
Kreit, J.
FEMS Microbiol. Lett.
366
fnz173
Identification, biological characteristics, and active site residues of 3-ketosteroid DELTA1-dehydrogenase homologues from Arthrobacter simplex
2020
Luo, J.M.; Cui, H.L.; Jia, H.C.; Li, F.; Cheng, H.J.; Shen, Y.B.; Wang, M.
J. Agric. Food Chem.
68
9496-9512
Identification, function, and application of 3-ketosteroid DELTA1-dehydrogenase isozymes in Mycobacterium neoaurum DSM 1381 for the production of steroidic synthons
2018
Zhang, R.; Liu, X.; Wang, Y.; Han, Y.; Sun, J.; Shi, J.; Zhang, B.
Microb. Cell Fact.
17
77
Universal capability of 3-ketosteroid ?1-dehydrogenases to catalyze DELTA1-dehydrogenation of C17-substituted steroids
2021
Wojcik, P.; Glanowski, M.; Wojtkiewicz, A.M.; Rohman, A.; Szaleniec, M.
Microb. Cell Fact.
20
119
Development of a synthetic 3-ketosteroid DELTA1-dehydrogenase for the generation of a novel catabolic pathway enabling cholesterol degradation in human cells
2019
D'Arcy, B.M.; Swingle, M.R.; Schambeau, L.; Pannell, L.; Prakash, A.; Honkanen, R.E.
Sci. Rep.
9
5969
Site-directed mutagenesis under the direction of in silico protein docking modeling reveals the active site residues of 3-ketosteroid-DELTA1-dehydrogenase from Mycobacterium neoaurum
2017
Qin, N.; Shen, Y.; Yang, X.; Su, L.; Tang, R.; Li, W.; Wang, M.
World J. Microbiol. Biotechnol.
33
146
Analysis and preliminary characterisation of the cytochrome P450 monooxygenases from Frankia sp. EuI1c (Frankia inefficax sp.)
2019
Lau, I.; Feyereisen, R.; Nelson, D.; Bell, S.
Arch. Biochem. Biophys.
669
11-21
Biophysical characterization of Aptenodytes forsteri cytochrome P450 aromatase
2018
Zarate-Perez, F.; Velazquez-Fernandez, J.B.; Jennings, G.K.; Shock, L.S.; Lyons, C.E.; Hackett, J.C.
J. Inorg. Biochem.
184
79-87
C-6alpha- vs C-7alpha-substituted steroidal aromatase inhibitors which is better? synthesis, biochemical evaluation, docking studies, and structure-activity relationships
2019
Roleira, F.M.F.; Varela, C.; Amaral, C.; Costa, S.C.; Correia-da-Silva, G.; Moraca, F.; Costa, G.; Alcaro, S.; Teixeira, N.A.A.; Tavares da Silva, E.J.
J. Med. Chem.
62
3636-3657
Differential effects of variations in human P450 oxidoreductase on the aromatase activity of CYP19A1 polymorphisms R264C and R264H
2020
Parween, S.; DiNardo, G.; Baj, F.; Zhang, C.; Gilardi, G.; Pandey, A.V.
J. Steroid Biochem. Mol. Biol.
196
105507