Ligand 2-dehydro-3-deoxy-D-gluconate

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Basic Ligand Information

Molecular Structure
Picture of 2-dehydro-3-deoxy-D-gluconate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H10O6
2-dehydro-3-deoxy-D-gluconate
WPAMZTWLKIDIOP-WVZVXSGGSA-N
Synonyms:
2-dehydro-3-deoxy-D-mannonate, 2-keto-3-deoxy-D-gluconate, 2-keto-3-deoxy-D-gluconic acid, 2-keto-3-deoxygluconate, 2-keto-3-deoxygluconic acid, 3-deoxy-D-erythro-hex-2-ulosonate, 3-deoxy-D-erythro-hex-2-ulosonic acid, D-2-dehydro-3-deoxygluconate, KDG


Show all pahtways known for Show all BRENDA pathways known for 2-dehydro-3-deoxy-D-gluconate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2-dehydro-3-deoxy-D-gluconate + NADH + H+ = 4-deoxy-L-erythro-5-hexoseulose + NAD+
show the reaction diagram
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2-dehydro-3-deoxy-D-gluconate + NAD+ = (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + NADH + H+
show the reaction diagram
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2-dehydro-3-deoxy-D-gluconate + NAD+ = (4S)-4,6-dihydroxy-2,5-dioxohexanoate + NADH
show the reaction diagram
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ATP + 2-dehydro-3-deoxy-D-gluconate = ADP + 2-dehydro-3-deoxy-6-phospho-D-gluconate
show the reaction diagram
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2-dehydro-3-deoxy-D-gluconate = pyruvate + D-glyceraldehyde
show the reaction diagram
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2-dehydro-3-deoxy-D-gluconate = pyruvate + D-glyceraldehyde
show the reaction diagram
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2-dehydro-3-deoxy-D-gluconate = pyruvate + D-glyceraldehyde
show the reaction diagram
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2-dehydro-3-deoxy-D-gluconate = pyruvate + D-glyceraldehyde
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
4-deoxy-L-erythro-5-hexoseulose + NAD+ = 2-dehydro-3-deoxy-D-gluconate + NADH + H+
show the reaction diagram
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(4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + NADPH = 2-dehydro-3-deoxy-D-gluconate + NADP+
show the reaction diagram
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2-dehydro-3-deoxy-D-glucose + NAD+ + H2O = 2-dehydro-3-deoxy-D-gluconate + NADH + H+
show the reaction diagram
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2-keto-3-deoxy-D-glucose + NADP+ + H2O = 2-keto-3-deoxy-D-gluconic acid + NADPH + H+
show the reaction diagram
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D-gluconate = 2-dehydro-3-deoxy-D-gluconate + H2O
show the reaction diagram
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D-gluconate = 2-dehydro-3-deoxy-D-gluconate + H2O
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (21 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2-dehydro-3-deoxy-D-gluconate + NADH + H+ = 4-deoxy-L-erythro-5-hexoseulose + NAD+
show the reaction diagram
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2-dehydro-3-deoxy-D-gluconate + NAD+ = (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + NADH + H+
show the reaction diagram
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2-dehydro-3-deoxy-D-gluconate + NAD+ = (4S)-4,6-dihydroxy-2,5-dioxohexanoate + NADH
show the reaction diagram
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ATP + 2-dehydro-3-deoxy-D-gluconate = ADP + 2-dehydro-3-deoxy-6-phospho-D-gluconate
show the reaction diagram
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2-dehydro-3-deoxy-D-gluconate = pyruvate + glyceraldehyde
show the reaction diagram
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2-dehydro-3-deoxy-D-gluconate = pyruvate + D-glyceraldehyde
show the reaction diagram
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2-dehydro-3-deoxy-D-gluconate = pyruvate + D-glyceraldehyde
show the reaction diagram
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2-dehydro-3-deoxy-D-gluconate = pyruvate + D-glyceraldehyde
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (25 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
4-deoxy-L-erythro-5-hexoseulose + NAD+ = 2-dehydro-3-deoxy-D-gluconate + NADH + H+
show the reaction diagram
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(4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + NADPH = 2-dehydro-3-deoxy-D-gluconate + NADP+
show the reaction diagram
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2-dehydro-3-deoxy-D-glucose + NAD+ + H2O = 2-dehydro-3-deoxy-D-gluconate + NADH + H+
show the reaction diagram
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3-deoxyglucosone + NAD+ + H2O = 2-keto-3-deoxygluconate + NADH + H+
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D-gluconate = 2-dehydro-3-deoxy-D-gluconate + H2O
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D-mannonate = 2-dehydro-3-deoxy-D-mannonate + H2O
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D-altronate = 2-dehydro-3-deoxy-D-gluconate + H2O
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D-Mannonate = 2-Dehydro-3-deoxy-D-gluconate + H2O
show the reaction diagram
D-gluconate = 2-dehydro-3-deoxy-D-gluconate + H2O
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

3D Structure of Enzyme-Ligand-Complex (PDB) (2 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (27 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
1.4
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at pH 7.9 and 25C
26.7
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at 60C in 50 mM sodium phosphate buffer (pH 6.2)

KM Value (29 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
13
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at pH 7.9 and 25C
7.7
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8.8
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at pH 8.0 and 42C
0.3
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at 60C in 50 mM sodium phosphate buffer (pH 6.2)

References & Links

Links to other databases for 2-dehydro-3-deoxy-D-gluconate

ChEBI
PubChem
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PubChem