Ligand N-acetyl-L-methionine

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Basic Ligand Information

Molecular Structure
Picture of N-acetyl-L-methionine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C7H13NO3S
N-acetyl-L-methionine
XUYPXLNMDZIRQH-LURJTMIESA-N
Synonyms:
Ac-Met, acetyl-L-methionine, acetyl-Met, acetyl-methionine, N-acetyl-L-Met, N-acetyl-Met, N-acetylmethionine, N-alpha-acetyl-L-methionine, Nac-L-Met, Nalpha-acetyl-L-methionine, Nalpha-acetylmethionine
Pathway Source
Pathways

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (17 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
N-acetyl-L-methionine + H2O = L-Met + acetate
show the reaction diagram
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N-acetylmethionine + H2O = acetate + methionine
show the reaction diagram
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Nalpha-acetyl-L-methionine + H2O = acetate + L-methionine
show the reaction diagram
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acetyl-methionine + H2O = methionine
show the reaction diagram
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N-acetyl-L-methionine + H2O = ?
show the reaction diagram
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N-acetyl-L-methionine + H2O = acetate + L-methionine
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (26 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
N-acetyl-L-methionine (S)-sulfoxide + thioredoxin = N-acetyl-L-methionine + thioredoxin disulfide + H2O
show the reaction diagram
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N-acetyl-L-methionine (S)-sulfoxide + reduced benzyl viologen = N-acetyl-L-methionine + oxidized benzyl viologen + H2O
show the reaction diagram
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acetyl-CoA + L-methionine = CoA + N-acetyl-L-methionine
show the reaction diagram
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N-acetyl-Met-tRNA + H2O = N-acetyl-Met + tRNA
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N-acetyl-D-methionine = N-acetyl-L-methionine
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
strong inhibition at 10 and 50 mM, in the presence of 0.1 mM MnCl2
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3D Structure of Enzyme-Ligand-Complex (PDB) (182 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (28 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.15
-
pH 8.0, 30°C
2.26
-
pH 7.5, 65°C, preincubation with CoCl2
22
-
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KM Value (56 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.81
-
-
0.84
-
pH 8.0, 30°C

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
247
-
-

References & Links

Links to other databases for N-acetyl-L-methionine

ChEBI
PubChem
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PubChem