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BRENDA support

Ligand N-(4-hydroxyphenyl)arachidonylamide

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Basic Ligand Information

Molecular Structure
Picture of N-(4-hydroxyphenyl)arachidonylamide (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C26H37NO2
N-(4-hydroxyphenyl)arachidonylamide
IJBZOOZRAXHERC-DOFZRALJSA-N
Synonyms:
(5Z,8Z,11Z,14Z)-N-(4-hydroxyphenyl)icosa-5,8,11,14-tetraenamide, AM404, N-(4-hydroxyphenyl)-5Z,8Z,11Z,14Z-eicosatetraenamide

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
N-(4-hydroxyphenyl)arachidonylamide + H2O = 4-aminophenol + arachidonic acid
show the reaction diagram
-
(5Z,8Z,11Z,14Z)-N-(4-hydroxyphenyl)icosa-5,8,11,14-tetraenamide + H2O = ?
show the reaction diagram
-

Inhibitor in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
i.e. AM404, an anandamide uptake inhibitor, IC50 is 0.0021 mM
-

Enzyme Kinetic Parameters

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0021
-
in the presence of fatty acid-free bovine serum albumin (0.125% w/v). In the absence of fatty acid-free bovine serum albumin, the IC50 value is reduced

IC50 Value (3 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.0021
-
i.e. AM404, an anandamide uptake inhibitor, IC50 is 0.0021 mM

References & Links

Links to other databases for N-(4-hydroxyphenyl)arachidonylamide

ChEBI
PubChem
-
PubChem