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Ligand thioredoxin 2 Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
thioredoxin 2 + NADP+ = thioredoxin 2 disulfide + NADPH + H+
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Substrate in Enzyme-catalyzed Reactions (2 results)
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thioredoxin 2 + NADP+ = thioredoxin 2 disulfide + NADPH + H+
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3'-phosphoadenylyl sulfate + thioredoxin 2 = adenosine 3',5'-bisphosphate + sulfite + thioredoxin 2 disulfide
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Enzyme Kinetic Parameters
kcat Value (Turnover Number) (2 results)
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42.9
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wild type enzyme, pH and temperature not specified in the publication
47.1
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mutant enzyme K137A, pH and temperature not specified in the publication
KM Value (3 results)
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0.0006
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wild type enzyme, pH and temperature not specified in the publication
0.0009
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mutant enzyme K137A, pH and temperature not specified in the publication
References & Links Literature References (3)
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New thioredoxins and glutaredoxins as electron donors of 3'-phosphoadenylylsulfate reductase
1999
Lillig, C.H.; Prior, A.; Schwenn, J.D.; Aslund, F.; Ritz, D.; Vlamis-Gardikas, A.; Holmgren, A.
J. Biol. Chem.
274
7695-7698
Insights into the specificity of thioredoxin reductase-thioredoxin interactions. A structural and functional investigation of the yeast thioredoxin system
2010
Oliveira, M.A.; Discola, K.F.; Alves, S.V.; Medrano, F.J.; Guimaraes, B.G.; Netto, L.E.
Biochemistry
49
3317-3326
Substrate and inhibitor specificities differ between human cytosolic and mitochondrial thioredoxin reductases: Implications for development of specific inhibitors
2011
Rackham, O.; Shearwood, A.M.; Thyer, R.; McNamara, E.; Davies, S.M.; Callus, B.A.; Miranda-Vizuete, A.; Berners-Price, S.J.; Cheng, Q.; Arner, E.S.; Filipovska, A.
Free Radic. Biol. Med.
50
689-699
Links to other databases for thioredoxin 2
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