Ligand N-formyl-L-methionine

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Basic Ligand Information

Molecular Structure
Picture of N-formyl-L-methionine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H11NO3S
N-formyl-L-methionine
PYUSHNKNPOHWEZ-YFKPBYRVSA-N
Synonyms:
formyl-Met, formyl-methionine, formylmethionine, N-formyl-L-Met, N-formyl-Lmethionine, N-formyl-Met, N-formyl-methionine, N-formylmethionine
Pathway Source
Pathways

Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
N-formyl-Met-Leu-Phe(fMLP) + H2O = N-formyl-Met + Leu-Phe(fMLP)
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (14 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
N-formyl-L-methionine + H2O = L-methionine + formate
show the reaction diagram
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N-formyl-L-methionine + H2O = formate + L-methionine
show the reaction diagram
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N-formyl-L-methionine + H2O = ?
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (26 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
N-formyl-Met-Leu-Phe(fMLP) + H2O = N-formyl-Met + Leu-Phe(fMLP)
show the reaction diagram
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N-Formyl-Met-Leu-Phe + H2O = N-Formyl-Met + Leu-Phe
show the reaction diagram
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N-formimino-L-methionine + H2O = N-formyl-L-methionine + NH3
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
non competitive inhibition, EDTA decreases the inhibition rate
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39% residual activity at 5 mM with L-methionine as substrate, 25% residual activity at 50 mM with D-methionine as substrate
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3D Structure of Enzyme-Ligand-Complex (PDB) (1537 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (6 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
23.03
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pH 8.0, 30C
839.1
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pH 7.5, 65C, preincubation with CoCl2
0.21
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nickel-containing enzyme

KM Value (14 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
6.01
-
pH 8.0, 30C

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.18
-
-

References & Links

Links to other databases for N-formyl-L-methionine

ChEBI
PubChem
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PubChem