Ligand 1-Pentanol

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Basic Ligand Information

Molecular Structure
Picture of 1-Pentanol (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C5H12O
1-Pentanol
OWFNMYDGQOUXRJ-UCXVSJSASA-N
Synonyms:
1-amylalcohol, amyl alcohol, n-amyl alcohol, n-Pentanol, pentan-1-ol, Pentanol

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
1-pentanol + NAD(P)+ = pentanal + NAD(P)H + H+
show the reaction diagram
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n-pentanol + O2 = n-pentanal + H2O2
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Substrate in Enzyme-catalyzed Reactions (54 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
n-pentanol + NAD+ + H2O = n-pentanal + NADH
show the reaction diagram
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1-pentanol + NAD+ = n-pentanal + NADH
show the reaction diagram
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pentanol + glutathione + NAD+ = ?
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1-pentanol + NAD+ = pentanal + NADH + H+
show the reaction diagram
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n-pentanol + NAD+ = n-pentanal + NADH
show the reaction diagram
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n-pentanol + NADP+ = n-pentanal + NADPH
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1-pentanol + ferricytochrome c = pentanal + ferrocytochrome c + H+
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1-pentanol + O2 = n-pentanal + H2O2
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1-pentanol + a quinone = pentanal + a quinol
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1-pentanol + acceptor = n-pentanal + reduced acceptor
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n-pentanol + NAD+ + H2O = ? + NADH
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1-pentanol + p-nitroso-N,N-dimethylaniline = n-pentanal + reduced p-nitroso-N,N-dimethylaniline
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O-acetyl-L-homoserine + n-pentanol = O-pentyl-homoserine + acetic acid
show the reaction diagram
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4-nitrophenyl sulfate + 1-pentanol = 4-nitrophenol + pentyl sulfate
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gallate + 1-pentanol = 1-pentyl gallate + H2O
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ferulate + pentanol = pentanyl ferulate + H2O
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phosphatidylcholine + pentanol = phosphatidylpentanol + choline
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beta-D-Gal-(1-3)-alpha-D-GalNAc-(1-O)-p-nitrophenyl + 1-pentanol = beta-D-Gal-(1-3)-alpha-D-GalNAc-(1-O)-pentyl + p-nitrophenol
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (45 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
valeraldehyde + NADH + H+ = pentan-1-ol + NAD+
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n-pentanal + NAD(P)H + H+ = n-pentanol + NAD(P)+
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pentanal + NADPH = pentanol + NADP+
show the reaction diagram
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pentanal + NADPH + H+ = 1-pentanol + NAD(P)+
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n-pentanal + NADPH + H+ = n-pentanol + NADP+
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pentanal + NADPH = pentanol + NADP+
show the reaction diagram
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valeraldehyde + NADH + H+ = n-pentanol + NAD+
show the reaction diagram
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pentane + NADH + H+ + O2 = pentan-1-ol + NAD+ + H2O
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pentane + NAD(P)H + O2 = 1-pentanol + 2-pentanol + NAD(P)+ + H2O
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pentane + reduced rubredoxin + O2 = 1-pentanol + oxidized rubredoxin + H2O
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2 pentane + 2 reduced acceptor + 2 H+ + 2 O2 = 1-pentanol + 2-pentanol + 2 acceptor + 2 H2O
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dipentylphthalate + H2O = pentylphthalate + pentanol
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amyl acetate = acetate + amyl alcohol
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n-pentyl beta-D-xylopyranoside + H2O = n-pentanol + beta-D-xylopyranose
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n-pentyl-beta-D-glucopyranoside + H2O = n-pentanol + D-glucose
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pentyl beta-D-glucopyranoside + H2O = pentanol + beta-D-glucopyranose
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n-amyl beta-D-glucopyranoside + H2O = 1-pentanol + beta-D-glucose
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5-hydroxypentylflavin + H2O = pentanol + lumichrome
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
20 mM, activates
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saturation concentration of activation at 60%, inhibition at higher concentration
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Inhibitor in Enzyme-catalyzed Reactions (11 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
2% v/v: 0-50% loss of activity, depending on substrate, enzyme regains activity after removal of alcohol
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27% inhibition at 5 mM
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complete inhibition at 10%
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about 10% residual activity at 10% (w/v)
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competitive to ethanolamine
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (24 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
407
-
pH 7.5, 30C
0.45
-
pH 7.5, 37C

KM Value (41 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
26.5
-
-
6.5
-
-
5.78
-
pH 7.5, 30C

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.58
-
-
35
-
pH 7.5, 25C

References & Links

Links to other databases for 1-Pentanol

ChEBI
PubChem
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PubChem