Ligand dGMP

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Basic Ligand Information

Molecular Structure
Picture of dGMP (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C10H14N5O7P
dGMP
LTFMZDNNPPEQNG-KVQBGUIXSA-N
Synonyms:
2'-deoxy-5'-guanylic acid, 2'-deoxyguanosine 5'-phosphate, 2'-deoxyguanosine 5'phosphate, 5'-dGMP, dGMP (or dTMP)

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + dGMP = ADP + dGDP
show the reaction diagram
-
5'-dGMP + H2O = deoxyguanosine + phosphate
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + 2'-deoxyguanosine = ADP + 2'-deoxyguanosine 5'-phosphate
show the reaction diagram
-
-
dGDP + H2O = dGMP + phosphate
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (25 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
dGMP + base = dNMP + guanine
show the reaction diagram
-
5'-dGMP + thymidine = TMP + 2'-deoxyguanosine
show the reaction diagram
-
ATP + dGMP = ADP + dGDP
show the reaction diagram
-
dGMP + [phosphate]n = dGDP + [phosphate]n-1
show the reaction diagram
-
5'-dGMP + H2O = deoxyguanosine + phosphate
show the reaction diagram
-
dGMP + H2O = deoxyguanosine + phosphate
show the reaction diagram
-
5'-dGMP + H2O = deoxyguanosine + phosphate
show the reaction diagram
-
5'-dGMP + H2O = deoxyguanosine + phosphate
show the reaction diagram
-
5'-dGMP + H2O = deoxyguanosine + phosphate
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (47 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + deoxyguanosine = ADP + dGMP
show the reaction diagram
-
-
ATP + deoxyguanosine = ADP + dGMP
show the reaction diagram
-
-
2'-deoxyguanosine 3',5'-bisphosphate + H2O = 2'-deoxyguanosine 5'-phosphate + phosphate
show the reaction diagram
-
-
polydeoxyguanylic acid + H2O = 5'-dGMP + 5'-phosphooligonucleotides
show the reaction diagram
-
dGDP + H2O = dGMP + phosphate
show the reaction diagram
-
-
dGTP + H2O = dGMP + diphosphate
show the reaction diagram
-
-
dGTP + H2O = dGMP + diphosphate
show the reaction diagram
-
-
dGDP + H2O = dGMP + phosphate
show the reaction diagram
-
-
dGDP + H2O = dGMP + phosphate
show the reaction diagram
-
-
ATP + dXMP + NH4+ = AMP + phosphate + dGMP
show the reaction diagram
-
-
(ribonucleotide)10-3'-phosphate + 5'-hydroxy-(ribonucleotide)10 + dGTP = (ribonucleotide)20 + dGMP + diphosphate
show the reaction diagram
-
-

Activator in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activation of hydrolysis of 3'-dTMP
-
1.0 mM, substrate cytosine, relative activity 109%
-

Inhibitor in Enzyme-catalyzed Reactions (26 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
0.5 mM, 32% inhibition
-
dTMP or 5-hydroxymethyl-dCMP as substrate
-
competitive
competitive to dTMP dephosphorylation
-
effective inhibition in presence of 1 mM GTP, noncompetitive inhibitor
-
noncompetitive inhibitor of dGTP hydrolysis
-

3D Structure of Enzyme-Ligand-Complex (PDB) (9 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (19 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
8.04
-
+/- 0.39
0.2
-
presence of Co2+, pH 8.0, 37°C
8.04
-
+/- 0.39

KM Value (40 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.085
-
pH 7.4, 37°C
0.094
-
reaction with ATP
0.7
-
-
0.28
-
+/- 0.04
0.047
-
presence of Co2+, pH 8.0, 37°C
0.28
-
+/- 0.04

Ki Value (19 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.15
-
dTMP as substrate, pH 7.6, 37°C
0.117
-
pH 7.4, 30°C
0.1666
-
pH 7.6, 37°C

References & Links

Links to other databases for dGMP

ChEBI
PubChem
ChEBI
PubChem