Ligand dGDP

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Basic Ligand Information

Molecular Structure
Picture of dGDP (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C10H15N5O10P2
dGDP
CIKGWCTVFSRMJU-KVQBGUIXSA-N
Synonyms:
2'-deoxy-GDP, 2'-deoxy-guanosine 5'-diphosphate, 2'-deoxy-L-GDP, 2'-deoxyGDP, 2'-deoxyguanosine 5'-diphosphate, 2'-dGDP, deoxyGDP, dGDP (or dTDP)


Show all pahtways known for Show all BRENDA pathways known for dGDP

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
dGDP + (phosphate)n+1 = dGTP + (phosphate)n
show the reaction diagram
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dGDP + H2O = dGMP + phosphate
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
GDP + thioredoxin = 2'-deoxyGDP + thioredoxin disulfide + H2O
show the reaction diagram
-
-
ATP + dGMP = ADP + dGDP
show the reaction diagram
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ATP + dGMP = ADP + dGDP
show the reaction diagram
-
-
dGTP + H2O = dGDP + phosphate
show the reaction diagram
-
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Substrate in Enzyme-catalyzed Reactions (24 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
dGDP + phosphoenolpyruvate = dGTP + pyruvate
show the reaction diagram
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dGDP + (phosphate)n+1 = dGTP + (phosphate)n
show the reaction diagram
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dGDP + H2O = dGMP + phosphate
show the reaction diagram
-
dGDP + H2O = dGMP + phosphate
show the reaction diagram
-
dGDP + H2O = dGMP + phosphate
show the reaction diagram
-
dGDP + H2O = dGMP + phosphate
show the reaction diagram
-
dGDP + H2O = dGMP + phosphate
show the reaction diagram
-
dGDP + H2O = ?
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (61 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
GDP + reduced thioredoxin = dGDP + oxidized thioredoxin + H2O
show the reaction diagram
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-
dGTP + D-ribose = dGDP + D-ribose 5-phosphate
show the reaction diagram
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dGTP + adenosylcobinamide = adenosylcobinamide phosphate + dGDP
show the reaction diagram
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dGTP + adenosine = dGDP + AMP
show the reaction diagram
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-
dGTP + thymidine = dGDP + dTMP
show the reaction diagram
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-
dGTP + 2-deoxy-D-ribose = dGDP + 2-deoxy-D-ribose 5-phosphate
show the reaction diagram
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dGTP + NAD+ = dGDP + NADP+
show the reaction diagram
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-
pantothenate + dGTP = 4'-phosphopantothenate + dGDP
show the reaction diagram
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dGTP + mevalonate = dGDP + phosphomevalonate
show the reaction diagram
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dGTP + uridine = dGDP + UMP
show the reaction diagram
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dGTP + 4-methyl-5-(2-hydroxyethyl)thiazole = dGDP + 4-methyl-5-(2-phosphonooxyethyl)thiazole
show the reaction diagram
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-
dGTP + D-galactose = dGDP + alpha-D-galactose 1-phosphate
show the reaction diagram
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dGTP + dAMP = dGDP + dADP
show the reaction diagram
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ATP + dGMP = ADP + dGDP
show the reaction diagram
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dGTP + AMP = dGDP + ADP
show the reaction diagram
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dGMP + [phosphate]n = dGDP + [phosphate]n-1
show the reaction diagram
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dGTP + H2O = dGDP + phosphate
show the reaction diagram
-
-
dGTP + H2O = dGDP + phosphate
show the reaction diagram
-
-
dGTP + H2O = dGDP + phosphate
show the reaction diagram
-
-
dGTP + H2O = dGDP + phosphate
show the reaction diagram
-
-
dGTP + H2O = dGDP + phosphate
show the reaction diagram
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dGTP + H2O + closed Cl- channel = dGDP + phosphate + open Cl- channel
show the reaction diagram
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dGTP + aminopterin + Glu = dGDP + phosphate + aminopteryl-Glu
show the reaction diagram
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L-glutamate + dGTP + coenzyme F420-0 = dGDP + phosphate + coenzyme F420-1
show the reaction diagram
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deoxyGTP + UTP + NH4+ = deoxyGDP + phosphate + CTP
show the reaction diagram
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2'-dGTP + IMP + L-aspartate = 2'-dGDP + phosphate + adenylosuccinate
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
40% less effective than dGTP
-

Inhibitor in Enzyme-catalyzed Reactions (20 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
12% inhibition at 0.5 mM
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product inhibition
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potent
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competitive to ATP
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0.2 mM, 46% inhibition
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0.5 mM, 23% inhibition
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slight inhibition
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3D Structure of Enzyme-Ligand-Complex (PDB) (5 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (6 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.51
-
substrate concentration between 0.01 and 4.0 mM, 37C
0.015
-
pH 8.0, 30C
0.008
-
pH 7.5, 37C

KM Value (10 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.051
-
substrate concentration between 0.01 and 4.0 mM, 37C
0.17
-
pH 8.0, 30C
0.32
-
pH 7.5, 37C

Ki Value (6 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
TABLE ID
0.0503
-
at pH 4.5 and 37C
11571
0.0077
-
-
11594
0.000053
-
at pH 7.5 and 30C
16299

IC50 Value (2 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.049
-
at pH 4.5 and 37C
0.00053
-
at pH 7.5 and 30C

References & Links

Links to other databases for dGDP

ChEBI
PubChem
ChEBI
PubChem