Ligand D-xylose

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Basic Ligand Information

Molecular Structure
Picture of D-xylose (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C5H10O5
D-xylose
SRBFZHDQGSBBOR-IOVATXLUSA-N
Synonyms:
D(+)-xylose, D-(+)-xylose, D-xylopyranose, D-xylose[in], D-xylose[side2], D-xylose[side 2], wood sugar, xylopyranose, xylose


Show all pahtways known for Show all BRENDA pathways known for D-xylose

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (49 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-xylose + NAD+ = D-xylono-1,5-lactone + NADH + H+
show the reaction diagram
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D-xylose + O2 = D-xylosone + H2O2
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D-xylose + O2 = ? + H2O2
show the reaction diagram
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D-xylose + 2,6-dichlorophenol-indophenol = ? + reduced 2,6-dichlorophenol-indophenol
show the reaction diagram
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D-xylose + oxidized 2,6-dichlorophenolindophenol = D-xylono-1,5-lactone + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
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D-xylose + O2 = ? + H2O2
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (27 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
xylitol + O2 = xylose + H2O2
show the reaction diagram
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notoginsenoside R1 + H2O = ginsenoside Rg1 + D-xylose
show the reaction diagram
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beta-1,3-xylan + H2O = xylose + xylooligosaccharides
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Fuc-alpha-(1-2)-Xyl + H2O = alpha-L-fucose + D-xylose
show the reaction diagram
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ginsenoside Rb3 + H2O = ginsenoside Rg3 + D-glucose + D-xylose
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (201 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-xylose + NADP+ = ?
show the reaction diagram
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D-xylose + NADP+ + H2O = ?
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D-xylose + NAD+ = D-xylono-1,4-lactone + NADH
show the reaction diagram
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D-xylose + NAD+ = D-xylono-1,5-lactone + NADH + H+
show the reaction diagram
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xylose + NADPH + H+ = xylitol + NADP+
show the reaction diagram
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D-xylose + NADH = ?
show the reaction diagram
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D-xylose + NADPH = ?
show the reaction diagram
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D-xylose + NAD+ = ? + NADH
show the reaction diagram
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D-xylose + NADPH = ? + NADP+
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D-xylose + NADPH = ?
show the reaction diagram
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D-xylose + NADPH + H+ = D-xylitol + NADP+
show the reaction diagram
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D-xylose + NADPH = ? + NADP+
show the reaction diagram
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D-xylose + NADPH = ? + NADP+
show the reaction diagram
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D-xylose + NADPH + H+ = ?
show the reaction diagram
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D-xylose + NADP+ = ? + NADPH + H+
show the reaction diagram
-
D-xylose + NADPH = xylitol + NADP+
show the reaction diagram
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D-xylose + NADP+ = D-xylonolactone + NADPH + H+
show the reaction diagram
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D-xylose + O2 = ?
show the reaction diagram
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D-xylose + O2 = D-xylono-1,4-lactone
show the reaction diagram
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D-xylose + phenazine methosulfate + O2 = D-xylosone + ?
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D-xylose + O2 = ? + H2O2
show the reaction diagram
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D-xylose + 2,6-dichlorophenolindophenol = ? + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
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D-xylose + 2,6-dichlorophenolindophenol = ?
show the reaction diagram
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D-xylose + NADP+ = D-xylono-1,5-lactone + NADPH + H+
show the reaction diagram
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D-xylose + ? = ?
show the reaction diagram
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UDP-alpha-D-glucose + D-xylose = ?
show the reaction diagram
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UDP-alpha-D-galactose + D-xylose = UDP + 4-O-beta-D-galactosyl-beta-D-xylose
show the reaction diagram
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soluble starch + D-xylose = ?
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starch + D-xylose = glucosyl-alpha-1,4-xylose + ?
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UDPgalactose + D-xylose = ?
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D-xylose + alpha-D-galactose 1-phosphate = beta-D-galactosyl-(1->4)-D-xylose + phosphate
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starch + D-xylose = oligosaccharides terminated by 4-O-alpha-D-glucopyranosyl-D-xylose
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D-xylose + alpha-D-mannose 1-phosphate = 4-O-beta-D-mannopyranosyl-D-xylopyranose + phosphate
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alpha-D-glucose 1-phosphate + D-xylose = ?
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xylose + beta-D-glucose 1-phosphate = glucosyl-1,1-xylose 1-phosphate
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phosphoenolpyruvate + D-xylose = 2-dehydro-3-deoxy-D-ido-octonate + phosphate
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ATP + D-xylose = ADP + D-xylose 5-phosphate
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ATP + D-xylose = ADP + D-xylose 1-phosphate
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ATP + D-xylose = ?
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ferulic acid + D-xylose = ?
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phosphatidylcholine + D-xylose = phosphatidylxylose + choline
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4-O-beta-D-mannopyranosyl-D-mannopyranose + D-xylose = ?
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2 D-xylose = xylobiose + H2O
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D-(+)-xylose + H2O = ?
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xylose + H2O = ?
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D-xylose + pyruvate = ?
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D-xylose = 2-dehydro-3-deoxy-D-xylonate + H2O
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D-xylose = D-lyxose
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D-Xylose = ?
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D-Xylose = D-Xylulose
show the reaction diagram
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D-Xylose = D-Xylulose
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (245 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
xylitol + NAD(P)+ = D-xylose + NAD(P)H + H+
show the reaction diagram
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D-xylitol + NADP+ = D-xylose + NADPH + H+
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D-xylose 1-phosphate + H2O = D-xylose + phosphate
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D-xylose 5-phosphate + H2O = D-xylose + phosphate
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D-xylose-1-phosphate + H2O = D-xylose + phosphate
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2-nitrophenyl beta-D-xylopyranoside + H2O = 2-nitrophenol + D-xylopyranose
show the reaction diagram
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2-nitrophenyl beta-D-xyloside + H2O = 2-nitrophenol + D-xylose
show the reaction diagram
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xylan + H2O = xylose + arabinose + xylobiose + high-molecular-mass oligosaccharides
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primeverose + H2O = D-xylose + D-glucose
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4-nitrophenyl beta-D-xylopyranoside + H2O = 4-nitrophenol + D-xylose
show the reaction diagram
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ginsenoside Rb3 + H2O = ginsenoside Rd + D-xylose
show the reaction diagram
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xylan + H2O = D-xylose + ?
show the reaction diagram
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Fuc-alpha-(1-2)-Xyl + H2O = alpha-L-fucose + D-xylose
show the reaction diagram
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xylan + H2O = xylose + ?
show the reaction diagram
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4-nitrophenyl beta-D-xylopyranoside + H2O = 4-nitrophenol + D-xylopyranose
show the reaction diagram
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ginsenoside Rb3 + H2O = ginsenoside Rg3 + D-glucose + D-xylose
show the reaction diagram
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2-nitrophenyl beta-D-xylopyranoside + H2O = 2-nitrophenol + D-xylopyranose
show the reaction diagram
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4-nitrophenyl beta-D-xylopyranoside + H2O = 4-nitrophenol + D-xylopyranose
show the reaction diagram
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4-nitrophenyl beta-D-xylopyranoside + H2O = 4-nitrophenol + D-xylose
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D-lyxose = D-xylulose + D-xylose
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (15 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
induces enzyme activity
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induces activity
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favores CGTase synthesis
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activates isoenzyme Hex II
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at high concentrations of 10-500 mM, enhanced activity with 4-nitrophenyl acetate as substrate
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slightly induces enzyme expression, gene axeII
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5 mM, 151% of initial activity
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xylonate dehydratase activity is induced 2fold in xylose-grown cells
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5 mM, 1.37fold activation
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Inhibitor in Enzyme-catalyzed Reactions (84 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
inhibits the oxidation of gluconolactone
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E 192, 3% inhibition
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mixed-type inhibitor
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0.4 M, 36% inhibition
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about 40% inhibition at 1% versus 1% sucrose
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at low concentrations of 1-5 mM, altered activity with 4-nitrophenyl acetate as substrate
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1.0 M, 13% inhibition
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5 mM, 33% inhibition
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10 mM, 0.4% amylose, relative activity 97%
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o-nitrophenyl-beta-D-galactoside hydrolyzing activity
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competitive
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Metals and Ions (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

3D Structure of Enzyme-Ligand-Complex (PDB) (17 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (187 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.7
-
pH 10.5, 60°C
1.22
-
50 mM
0.06
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in 50 mM Tris-HCl (pH 7.2), at 25°C
356
-
pH 8.3, 37°C
200
-
-
2.6
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wild type enzyme, in 25 mM Tris-HCl pH 7.5, at 25°C
19
-
recombinant enzyme, pH 7.0, 37°C, reverse reaction
29.9
-
pH 8.0, 37°C
5.6
-
at pH 7.5 and 85°C
33
-
-

KM Value (346 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
1.4
-
-
402
-
pH 7.5, 37°C
0.467
-
-
190
-
-
135
-
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333
-
-
104
-
50 mM
8.48
-
in 50 mM Tris-HCl (pH 7.2), at 25°C
28
-
-
45
-
-
370
-
recombinant enzyme, pH 7.0, 37°C, reverse reaction
19.2
-
pH 8.0, 37°C
418
-
at pH 7.5 and 85°C
-999
-
0.72 mg/ml, Vmax = 2854 micromol/min/mg protein
23
-
-

Ki Value (21 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
1000
-
30°C, pH 6.6
69.5
-
37°C, pH 7.0, wild-type enzyme
13.7
-
pH 4.8, temperature not specified in the publication

IC50 Value (2 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE

References & Links