Ligand sorbitol

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Basic Ligand Information

Molecular Structure
Picture of sorbitol (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H14O6
sorbitol
ZPVSJMBECDCVRC-AWCRTANDSA-N
Synonyms:
(2S,3R,4R,5R)-hexane-1,2,3,4,5,6-hexaol, allitol, D-glucitol, D-glucitol[side 1], D-sorbitol[side 1], rac-(2R,3R,4R,5S)-hexane-1,2,3,4,5,6-hexaol

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
sorbitol + NAD+ = D-fructose + NADH
show the reaction diagram
sorbitol + NAD+ = D-fructose + NADH
show the reaction diagram
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sorbitol + NAD+ = D-fructose + NADH + H+
show the reaction diagram
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sorbitol + NAD+ = ?
show the reaction diagram
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sorbitol + O2 = ?
show the reaction diagram
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sorbitol + O2 = ?
show the reaction diagram
D-glucitol + NAD+ = D-fructose + NADH + H+
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
fructose + NADPH = sorbitol + NADP+
show the reaction diagram
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D-glucose + NADPH + H+ = sorbitol + NADP+
show the reaction diagram
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D-glucose + NADPH + H+ = sorbitol + NADP+
show the reaction diagram
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sorbitol 6-phosphate + H2O = sorbitol + phosphate
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (34 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-glucitol + NAD+ = ? + NADH
show the reaction diagram
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D-glucitol + NAD+ = ?
show the reaction diagram
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D-glucitol + NADP+ = D-glucose + NADPH + H+
show the reaction diagram
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D-glucitol + NAD+ = D-fructose + NADH + H+
show the reaction diagram
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sorbitol + NAD+ = D-fructose + NADH + H+
show the reaction diagram
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D-glucitol + NAD+ = D-gulose + NADH
show the reaction diagram
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sorbitol + NAD+ = ?
show the reaction diagram
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sorbitol + NAD+ = ?
show the reaction diagram
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sorbitol + NAD+ = ? + NADH
show the reaction diagram
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sorbitol + NAD+ = D-fructose + NADH + H+
show the reaction diagram
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sorbitol + O2 = ?
show the reaction diagram
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D-glucitol + O2 = D-glucose + H2O2
show the reaction diagram
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sorbitol + O2 = ?
show the reaction diagram
D-glucitol + NAD+ = D-fructose + NADH + H+
show the reaction diagram
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sucrose + sorbitol = ?
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sucrose + sorbitol = ?
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phosphohistidinoprotein + D-glucitol = histidine-containing protein + D-glucitol phosphate
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[protein]-Npi-phospho-L-histidine + D-glucitol[side 1] = [protein]-L-histidine + D-glucitol 1-phosphate[side 2]
show the reaction diagram
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[protein]-Npi-phospho-L-histidine + D-glucitol[side 1] = [protein]-L-histidine + D-glucitol 1-phosphate[side 2]
show the reaction diagram
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ATP + allitol = ADP + allitol 6-phosphate
show the reaction diagram
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sorbitol + phenyl alpha-D-galactoside = ?
show the reaction diagram
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di-N-acetylchitobiose + sorbitol = ?
show the reaction diagram
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Galbeta(1-3)GalNAcalpha(1-)p-nitrophenyl + sorbitol = ?
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (30 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
fructose + NADPH = sorbitol + NADP+
show the reaction diagram
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D-glucose + NADPH + H+ = D-glucitol + NADP+
show the reaction diagram
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D-glucose + NADPH + H+ = sorbitol + NADP+
show the reaction diagram
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D-psicose + NADH + H+ = allitol + NAD+
show the reaction diagram
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D-glucose + NADPH = sorbitol + NADP+
show the reaction diagram
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D-fructose + NADH + H+ = sorbitol + NAD+
show the reaction diagram
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sorbitol-6-phosphate + H2O = sorbitol + phosphate
show the reaction diagram
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D-glucitol-6-phosphate + H2O = D-glucitol + phosphate
show the reaction diagram
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sorbitol 6-phosphate + H2O = sorbitol + phosphate
show the reaction diagram
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maltitol 6-phosphate + H2O = alpha-D-glucopyranosyl 6-phosphate + D-glucitol
show the reaction diagram
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lactitol + H2O = D-galactose + D-glucitol
show the reaction diagram
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cellotriitol + H2O = cellobiose + sorbitol
show the reaction diagram
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isomaltotriitol + H2O = isomaltose + sorbitol
show the reaction diagram
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D-dichlorosorboflavin + H2O = 7,8-dichloro-10-hydroxybenzo[g]pteridine-2,4(3H,10H)-dione + rac-(2R,3R,4R,5S)-hexane-1,2,3,4,5,6-hexaol
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (18 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
600 mosmol per kg H2O, up to 2fold increase in activity
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0.6 mM
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53.26% increased yield of S-adenosyl-L-methionine at 1.2% sorbitol
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induces phosphorylation of Ser526, response to osmotic stress
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rapid activation in vivo
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presence of sorbitol and trehalose significantly increase the substrate affinity and catalytic efficiency of glucoamylases GAM-1 and GAM-2
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30% w/v, activates more than 10fold
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increases the enzyme activity up to 110% at 37°C, gives rise to an increase in the content of alpha-helix and beta-sheets elements
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0.4 M, 62.0% residual activity after 60°C heat treatment
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Inhibitor in Enzyme-catalyzed Reactions (18 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive inhibition with NADP+ and glucose
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0.8 M, 27% inhibition
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0.25M
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competitive
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competitive
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inhibitory action at 30 and 40% solution
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5 mM, slight inhibition of starch hydrolysis
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4 mM
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weak
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3D Structure of Enzyme-Ligand-Complex (PDB) (54 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (3 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.8
-
-

KM Value (8 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
560
-
-
107
-
pH 9, 30°C
32
-
-
0.8
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at pH 7.6 and 25°C

References & Links

Links to other databases for sorbitol

ChEBI
PubChem
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PubChem