Ligand 3-hydroxypalmitoyl-CoA
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Basic Ligand Information
Molecular Structure

C37H66N7O18P3S
3-hydroxypalmitoyl-CoA
DEHLMTDDPWDRDR-IPSCRTIASA-N
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)
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3-hydroxypalmitoyl-CoA + H2O = 3-hydroxypalmitate + CoA
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Substrate in Enzyme-catalyzed Reactions (3 results)
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3-hydroxypalmitoyl-CoA + H2O = CoA + 3-hydroxypalmitate
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3-hydroxypalmitoyl-CoA + H2O = 3-hydroxypalmitate + CoA
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3-hydroxypalmitoyl-CoA = 2,3-trans-hexadecenoyl-CoA + H2O
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Enzyme Kinetic Parameters
KM Value (4 results)
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0.0068
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isoform HCAD4, in 50 mM HEPES-NaOH (pH 7.4), 150 mM NaCl, 10% (v/v) glycerol, 1 mM dithiothreitol, 1 mM phenylmethylsulfonyl fluoride, at 37°C
0.0336
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isoform HCAD1, in 50 mM HEPES-NaOH (pH 7.4), 150 mM NaCl, 10% (v/v) glycerol, 1 mM dithiothreitol, 1 mM phenylmethylsulfonyl fluoride, at 37°C
0.0495
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isoform HCAD3, in 50 mM HEPES-NaOH (pH 7.4), 150 mM NaCl, 10% (v/v) glycerol, 1 mM dithiothreitol, 1 mM phenylmethylsulfonyl fluoride, at 37°C
0.1217
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isoform HCAD2, in 50 mM HEPES-NaOH (pH 7.4), 150 mM NaCl, 10% (v/v) glycerol, 1 mM dithiothreitol, 1 mM phenylmethylsulfonyl fluoride, at 37°C
References & Links
Literature References (3)
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Characterization of an acyl-coA thioesterase that functions as a major regulator of peroxisomal lipid metabolism
2002
Hunt, M.C.; Solaas, K.; Kase, B.F.; Alexson, S.E.
J. Biol. Chem.
277
1128-1138
Characterization of four mammalian 3-hydroxyacyl-CoA dehydratases involved in very long-chain fatty acid synthesis
2008
Ikeda, M.; Kanao, Y.; Yamanaka, M.; Sakuraba, H.; Mizutani, Y.; Igarashi, Y.; Kihara, A.
FEBS Lett.
582
2435-2440
Membrane topology and essential amino acid residues of Phs1, a 3-hydroxyacyl-CoA dehydratase involved in very long-chain fatty acid elongation
2008
Kihara, A.; Sakuraba, H.; Ikeda, M.; Denpoh, A.; Igarashi, Y.
J. Biol. Chem.
283
11199-11209
Links to other databases for 3-hydroxypalmitoyl-CoA