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Ligand phenylacetyl-CoA

Basic Ligand Information

Molecular Structure

Show all BRENDA pathways known for phenylacetyl-CoA

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (4 results)

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Show Natural Substrate (4 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.17.5.1

phenylacetyl-CoA + H2O + ubiquinone = phenylglyoxylyl-CoA + ubiquinol

644661

-

2.3.1.14

phenylacetyl-CoA + L-glutamine = CoA + alpha-N-phenylacetyl-L-glutamine

486317

-

2.3.1.164

phenylacetyl-CoA + isopenicillin N + H2O = CoA + benzylpenicillin + L-2-aminohexanedioate

441304

-

2.3.1.164

phenylacetyl-CoA + isopenicillin N + H2O = CoA + penicillin G + L-2-aminohexanedioate

673028, 686918, 718653, 720282

-

2.3.1.164

2 entries

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

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Show Natural Product (2 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

6.2.1.2

ATP + phenylacetate + CoA = AMP + diphosphate + phenylacetyl-CoA

0

-

6.2.1.30

ATP + phenylacetate + CoA = AMP + diphosphate + phenylacetyl-CoA

0

-

Substrate in Enzyme-catalyzed Reactions (36 results)

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Show Substrate (36 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.13.11.80

phenylacetyl-CoA + O2 = phenylglyoxylate + CoA

729199, 730839

-

1.14.13.149

phenylacetyl-CoA + O2 + NADPH + H+ = 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + H2O + NADP+

716755, 718163, 717032

-

1.17.5.1

phenylacetyl-CoA + H2O + 2,6-dichlorophenolindophenol = phenylglyoxylyl-CoA + reduced 2,6-dichlorophenolindophenol

644662, 644661

-

1.17.5.1

phenylacetyl-CoA + H2O + duroquinone = phenylglyoxylyl-CoA + duroquinol

644661

-

1.17.5.1

phenylacetyl-CoA + H2O + menadione = phenylglyoxylyl-CoA + menadiol

644661

-

1.17.5.1

phenylacetyl-CoA + H2O + quinone = phenylglyoxylyl-CoA + quinol

644661, 644662

-

1.17.5.1

phenylacetyl-CoA + H2O + ubiquinone = phenylglyoxylyl-CoA + ubiquinol

644661

-

1.17.5.1

5 entries

2.3.1.13

phenylacetyl-CoA + glycine = CoA + N-phenylacetylglycine

486267

-

2.3.1.14

phenylacetyl-CoA + glycine = CoA + phenylacetylglycine

486317, 486318

-

2.3.1.14

phenylacetyl-CoA + L-glutamine = CoA + alpha-N-phenylacetyl-L-glutamine

486317

-

2.3.1.14

2 entries

2.3.1.151

3 malonyl-CoA + phenylacetyl-CoA = 4 CoA + 4-hydroxy-6-(2-oxo-3-phenylpropyl)-2H-pyran-2-one + 6-benzyl-4-hydroxy-2H-pyran-2-one + 2-phenyl-1-(2,4,6-trihydroxyphenyl)ethanone + 3 CO2

720639

-

2.3.1.159

phenylacetyl-CoA + malonyl-CoA = 2,4,6-trihydroxyphenylbenzylketone + CoA + CO2

673581

-

2.3.1.164

phenylacetyl-CoA + 6-aminopenicillanic acid + H2O = CoA + benzylpenicillin

441303, 441304

-

2.3.1.164

phenylacetyl-CoA + isopenicillin N + H2O = CoA + benzylpenicillin + L-2-aminohexanedioate

441304

-

2.3.1.164

phenylacetyl-CoA + isopenicillin N + H2O = CoA + penicillin G + L-2-aminohexanedioate

673028, 686918, 718653, 720282

-

2.3.1.164

3 entries

2.3.1.186

phenylacetyl-CoA + pseudotropine = CoA + O-phenylacetylpseudotropine

682363

-

2.3.1.192

phenylacetyl-CoA + glycine = phenylacetylglycine + CoA

707446, 487438, 486265

-

2.3.1.192

phenylacetyl-CoA + L-arginine = ? + CoA

487438

-

2.3.1.192

phenylacetyl-CoA + L-asparagine = ? + CoA

486265

-

2.3.1.192

phenylacetyl-CoA + L-glutamine = ? + CoA

487438, 486265

-

2.3.1.192

phenylacetyl-CoA + L-glutamine = phenylacetyl-L-glutamine + CoA

487441

-

2.3.1.192

5 entries

2.3.1.220

3 malonyl-CoA + phenylacetyl-CoA = 4 CoA + 2,4,6-trihydroxyphenylbenzylketone + 3 CO2

487479

-

2.3.1.233

phenylacetyl-CoA = 6-benzyl-4-hydroxy-2-pyrone + 4-hydroxy-6-(2'-oxo-3'-phenylpropyl)-2-pyrone + CoA + CO2 + H2O

729157

-

2.3.1.253

phenylacetyl-CoA = 6-(cyclohepta-1,3,6-trien-1-yl)-4-hydroxy-2H-pyran-2-one + 6-[2-(cyclohepta-1,3,6-trien-1-yl)-2-oxoethyl]-4-hydroxy-2H-pyran-2-one + CO2 + CoA

740681

-

2.3.1.68

phenylacetyl-CoA + L-glutamine = CoA + phenylacetyl-L-glutamine

486266

-

2.3.1.71

phenylacetyl-CoA + glycine = CoA + N-phenylacetylglycine

487440, 718757

-

2.3.1.71

phenylacetyl-CoA + L-glutamine = CoA + N-phenylacetyl-L-glutamine

718757

-

2.3.1.71

2 entries

2.3.1.74

malonyl-CoA + phenylacetyl-CoA = phlorobenzylketone + CoA + Co2

487479

-

2.3.1.85

phenylacetyl-CoA + an [acyl-carrier protein] = CoA + phenylacetyl-[acyl-carrier protein]

755686

-

2.3.3.2

phenylacetyl-CoA + H2O + oxaloacetate = phenylcitrate + CoA

488156

-

2.7.8.7

phenylacetyl-CoA + apo-[acyl-carrier protein] = ? + holo-[acyl-carrier protein]

645404

-

3.1.2.20

phenylacetyl-CoA + H2O = CoA + phenylacetate

707430, 732296, 690932, 707486

-

3.1.2.25

phenylacetyl-CoA + H2O = phenylacetate + CoA

653136, 751066

-

3.1.2.B5

phenylacetyl-CoA + H2O = phenylacetate + CoA

727853

-

6.2.1.13

ADP + phosphate + phenylacetyl-CoA = ATP + phenylacetate + CoA

660834, 626

-

6.2.1.B11

ADP + phosphate + phenylacetyl-CoA = ATP + phenylacetate + CoA

651712

-

Product in Enzyme-catalyzed Reactions (13 results)

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Show Product (13 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.2.7.11

phenylpyruvate + CoA + 2 methyl viologen = phenylacetyl-CoA + CO2 + 2 reduced methyl viologen + 2 H+

0

-

1.2.7.7

phenylpyruvate + CoA + oxidized ferredoxin = phenylacetyl-CoA + CO2 + reduced ferredoxin

0

-

1.2.7.8

phenylpyruvate + CoA + oxidized ferredoxin = phenylacetyl-CoA + CO2 + reduced ferredoxin

0

-

1.2.7.8

phenylpyruvate + CoA + oxidized methyl viologen = phenylacetyl-CoA + CO2 + reduced methyl viologen + H+

0

-

1.2.7.8

2 entries

6.2.1.13

ATP + phenylacetate + CoA = ADP + phosphate + phenylacetyl-CoA

0

-

6.2.1.2

ATP + phenylacetate + CoA = AMP + diphosphate + phenylacetyl-CoA

651834, 0

-

6.2.1.25

ATP + phenylacetate + CoA = AMP + diphosphate + phenylacetyl-CoA

651721, 649526

-

6.2.1.27

ATP + phenylacetate + CoA = AMP + phenylacetyl-CoA + diphosphate

0

-

6.2.1.30

ATP + phenylacetate + CoA = AMP + diphosphate + phenylacetyl-CoA

648918, 648917, 0, 648919, 648921, 648914, 648915, 648920, 648916

-

6.2.1.30

CTP + phenylacetate + CoA = CMP + diphosphate + phenylacetyl-CoA

0

-

6.2.1.30

UTP + phenylacetate + CoA = UMP + diphosphate + phenylacetyl-CoA

0

-

6.2.1.B11

ATP + phenylacetate + CoA = ADP + phosphate + phenylacetyl-CoA

0

-

6.2.1.B11

GTP + phenylacetate + CoA = GDP + phosphate + phenylacetyl-CoA

0

-

6.2.1.30

3 entries

6.2.1.B11

2 entries

Inhibitor in Enzyme-catalyzed Reactions (3 results)

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Show Inhibitors (3 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.6

-

487315

-

2.3.1.71

-

486265

-

3.1.2.23

inhibits the hydrolysis of benzoyl-CoA

690642

-

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (14 results)

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Show Turnover Number (14 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

1.13.11.80

0.017

-

pH 7.5, 24°C

730839

1.13.11.80

0.064

-

pH 7.5, 24°C, wild-type enzyme

729199

1.13.11.80

2 entries

1.17.5.1

12

-

pH 7.5, 30°C, duroquinone as electron acceptor

644661

2.3.1.85

6

-

didomain construct, pH not specified in the publication, 25°C

755686

3.1.2.20

0.084

-

wild-type protein, pH7.5, 25°C

707486

3.1.2.20

0.12

-

-

707430

3.1.2.20

3.2

-

pH 7.5, 37°C

732296

3.1.2.20

9.4

-

pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay

690932

3.1.2.20

130

-

pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay

690932

3.1.2.20

5 entries

3.1.2.25

6.5

-

wild type enzyme, at pH 7.6 and 21°C

751066

3.1.2.B5

0.41

-

pH 8.1, 25°C, wild-type enzyme

727853

3.1.2.B5

3.7

-

pH 8.1, 25°C, wild-type enzyme

727853

3.1.2.B5

2 entries

6.2.1.13

138

-

isoenzyme ACS II

626

6.2.1.B11

2.3

-

pH 8.0, 55°C

651712

K_M Value (17 results)

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Show KM Value (17 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.13.11.80

0.102

-

pH 7.5, 24°C, wild-type enzyme

729199

1.13.11.80

0.3

-

pH 7.5, 24°C

730839

1.13.11.80

2 entries

1.17.5.1

0.02

-

pH 7.5, 30°C, 2,6-dichlorophenolindophenol as electron acceptor

644661

2.3.1.13

0.15

-

cosubstrate glycine

486267

2.3.1.68

0.035

-

-

486266

2.3.1.85

0.00096

-

didomain construct, pH not specified in the publication, 25°C

755686

3.1.2.20

0.0016

-

pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay

690932

3.1.2.20

0.016

-

pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay

690932

3.1.2.20

0.0498

-

pH 7.5, 37°C

732296

3.1.2.20

0.1916

-

-

707430

3.1.2.20

0.24

-

wild-type protein, pH7.5, 25°C

707486

3.1.2.20

5 entries

3.1.2.25

3.95

-

-

653136

3.1.2.B5

0.0096

-

pH 8.1, 25°C, wild-type enzyme

727853

3.1.2.B5

0.39

-

pH 8.1, 25°C, wild-type enzyme

727853

6.2.1.13

0.004

-

isoenzyme ACS II

626

6.2.1.13

0.11

-

pH 6.5, 85°C

660834

3.1.2.B5

2 entries

6.2.1.13

2 entries

6.2.1.B11

0.017

-

pH 8.0, 55°C

651712

K_i Value (1 result)

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Show KI Value (1 entry)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.3.1.6

0.00031

-

-

487315

References & Links

Literature References (55)

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Show Reference (55 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

626

8830684

Purification and characterization of two reversible and ADP-dependent acetyl coenzyme A synthetases from the hyperthermophilic archaeon Pyrococcus furiosus

1996

Mai, X.; Adams, M.W.W.

J. Bacteriol.

178

5897-5903

441303

7519594

Molecular characterization of three loss-of-function mutations in the isopenicillin N-acyltransferase gene (penDE) of Penicillium chrysogenum

1994

Fernandez, F.J.; Gutierrez, S.; Velasco, J.; Montenegro, E.; Marcos, A.T.; Martin, J.F.

J. Bacteriol.

176

4941-4948

441304

8082826

Acyl-coenzyme A:isopenicillin N acyltransferase from Penicillium chrysogenum: effect of amino acid substitutions at Ser227, Ser230 and Ser309 on proenzyme cleavage and activity

1994

Tobin, M.B.; Cole, S.C.J.; Kovacevic, S.; Miller, J.R.; Baldwin, J.E.; Sutherland, J.D.

FEMS Microbiol. Lett.

121

39-46

486265

457678

Benzoyl-coenzyme A:glycine N-acyltransferase and phenylacetyl-coenzyme A:glycine N-acyltransferase from bovine liver mitochondria. Purification and characterization

1979

Nandi, D.L.; Lucas, S.V.; Webster, L.T.

J. Biol. Chem.

254

7230-7237

486266

931988

Identification of separate acyl-CoA:glycine and acyl-CoA:L-glutamine N-acyltransferase activities in mitochondrial fractions from liver of rhesus monkey and man

1976

Webster, L.T.; Siddiqui, U.A.; Lucas, S.V.; Strong, J.M.; Mieyal, J.J.

J. Biol. Chem.

251

3352-3358

486267

666745

A radiochemical assay for glycine N-acyltransferase activity. Some properties of the enzyme in rat and rabbit

1978

James, M.O.; Bend, J.R.

Biochem. J.

172

285-291

486317

13491597

Synthesis of phenylacetylglutamine by human tissue

1957

Moldave, K.; Meister, A.

J. Biol. Chem.

229

463-476

486318

1673104

Enzymes that metabolize acyl-coenzyme A in the monkey-their distribution, properties and roles in an alternative pathway for the excretion of nitrogen

1991

Asaoka, K.

Int. J. Biochem.

23

429-434

487315

6142928

On the possible mechanism of phenylacetate neurotoxicity: inhibition of choline acetyltransferase by phenylacetyl-CoA

1984

Potempska, A.; Loo, Y.H.; Wisniewski, M.M.

J. Neurochem.

42

1499-1501

487438

2283662

The effects of ions on the conjugation of xenobiotics by the aralkyl-CoA and arylacetyl-CoA N-acyltransferases from bovine liver mitochondria

1990

Kelley, M.; Vessey, D.A.

J. Biochem. Toxicol.

5

125-135

487440

8355261

Isolation and characterization of mitochondrial acyl-CoA: glycine N-acyltransferases from kidney

1993

Kelley, M.; Vessey, D.A.

J. Biochem. Toxicol.

8

63-69

487441

7983681

Characterization of the acyl-CoA:amino acid N-acyltransferases from primate liver mitochondria

1994

Kelley, M.; Vessey, D.A.

J. Biochem. Toxicol.

9

153-158

487479

11112437

Enzymatic Formation of Unnatural Aromatic Polyketides by Chalcone Synthase

2000

Morita, H.; Takahashi, Y.; Noguchi, H.; Abe, I.

Biochem. Biophys. Res. Commun.

279

190-195

488156

5719165

A metabolic variation in Penicillium spiculisporum Lehman

1968

Mahlen, A.; Gatenbeck, S.

Acta Chem. Scand.

22

2617-2623

644661

10336636

Phenylacetyl-CoA:acceptor oxidoreductase, a membrane-bound molybdenum-iron-sulfur enzyme involved in anaerobic metabolism of phenylalanine in the denitrifying bacterium Thauera aromatica

1999

Rhee, S.K.; Fuchs, G.

Eur. J. Biochem.

262

507-515

644662

9575237

Phenylacetyl-CoA:acceptor oxidoreductase, a new a-oxidizing enzyme that produces phenylglyoxylate. Assay, membrane localization, and differential production in Thauera aromatica

1998

Schneider, S.; Fuchs, G.

Arch. Microbiol.

169

509-516

645404

9484229

Characterization of Sfp, a Bacillus subtilis phosphopantetheinyl transferase for peptidyl carrier protein domains in peptide synthetases

1998

Quadri, L.E.; Weinreb, P.H.; Lei, M.; Nakano, M.M.; Zuber, P.; Walsh, C.T.

Biochemistry

37

1585-1595

648914

2324116

Purification and biochemical characterization of phenylacetyl-CoA ligase from Pseudomonas putida

1990

Martinez-Blanco, H.; Reglero, A.; Rodriguez-Aparicio, L.B.; Luengo, J.M.

J. Biol. Chem.

265

7084-7090

648915

2009287

Fluorometric determination of phenylacetyl-CoA ligase from Pseudomonas putida: a very sensitive assay for a newly described enzyme

1991

Rodriguez-Aparacio, L.B.; Reglero, A.; Martinez-Blanco, H.; Luengo, J.M.

Biochim. Biophys. Acta

1073

431-433

648916

8352645

Purification and characterization of phenylacetyl-coenzyme A ligase from a denitrifying Pseudomonas sp., an enzyme involved in the anaerobic degradation of phenylacetate

1993

El-Said Mohamed, M.; Fuchs, G.

Arch. Microbiol.

159

544-562 (c)

648917

6819990

Biosynthesis of Penicillin in vitro: purification & properties of phenyl/phenoxyacetic acid activating enzyme

1982

Kogekar, R.G.; Desphpande, V.N.

Indian J. Biochem. Biophys.

19

257-261

648918

8472917

Phenylacetate-coenzyme A ligase is induced during growth on phenylacetic acid in different bacteria of several genera

1993

Vitovski, S.

FEMS Microbiol. Lett.

108

1-5

648919

12189419

Aerobic metabolism of phenylacetic acids in Azoarcus evansii

2002

Mohamed Mel, S.; Ismail, W.; Heider, J.; Fuchs, G.

Arch. Microbiol.

178

180-192

648920

8969218

Molecular cloning and expression in different microbes of the DNA encoding Pseudomonas putida U phenylacetyl-CoA ligase. Use of this gene to improve the rate of benzylpenicillin biosynthesis in Penicillium chrysogenum

1996

Minambres, B.; Martinez-Blanco, H.; Olivera, E.R.; Garcia, B.; Diez, B.; Barredo, J.L.; Moreno, M.A.; Schleissner, C.; Salto, F.; Luengo, J.M.

J. Biol. Chem.

271

33531-33538

648921

10629172

Biochemical and molecular characterization of phenylacetate-coenzyme A ligase, an enzyme catalyzing the first step in aerobic metabolism of phenylacetic acid in Azoarcus evansii

2000

Mohamed, M.E.S.

J. Bacteriol.

182

286-294

649526

12054436

Purification and characterization of benzoate:coenzyme A ligase from Clarkia breweri

2002

Beuerle, T.; Pichersky, E.

ARCH. BIOCHEM. BIOPHYS.

400

258-264

651712

11790732

Novel type of ADP-forming acetyl coenzyme A synthetase in hyperthermophilic archaea: heterologous expression and characterization of isoenzymes from the sulfate reducer Archaeoglobus fulgidus and the methanogen Methanococcus jannaschii

2002

Musfeldt, M.; Schonheit, P.

J. Bacteriol.

184

636-644

651721

12897012

Benzoate-coenzyme A ligase from Thauera aromatica: an enzyme acting in anaerobic and aerobic pathways

2003

Schuhle, K.; Gescher, J.; Feil, U.; Paul, M.; Jahn, M.; Schagger, H.; Fuchs, G.

J. Bacteriol.

185

4920-4929

651834

12616642

Isolation, sequencing, and expression of a cDNA for the HXM-A form of xenobiotic/medium-chain fatty acid:CoA ligase from human liver mitochondria

2003

Vessey, D.A.; Lau, E.; Kelley, M.; Warren, R.S.

J. Biochem. Mol. Toxicol.

17

1-6

653136

237213

Phenylacetyl coenzyme A hydrolase

1975

Brian, S.

Methods Enzymol.

43

482-487

660834

15340786

Unusual ADP-forming acetyl-coenzyme A synthetases from the mesophilic halophilic euryarchaeon Haloarcula marismortui and from the hyperthermophilic crenarchaeon Pyrobaculum aerophilum

2004

Bräsen, C.; Schönheit, P.

Arch. Microbiol.

182

277-287

673028

17379148

Deacetylcephalosporin C production in Penicillium chrysogenum by expression of the isopenicillin N epimerization, ring expansion, and acetylation genes

2007

Ullan, R.V.; Campoy, S.; Casqueiro, J.; Fernandez, F.J.; Martin, J.F.

Chem. Biol.

14

329-339

673581

17250741

An acridone-producing novel multifunctional type III polyketide synthase from Huperzia serrata

2007

Wanibuchi, K.; Zhang, P.; Abe, T.; Morita, H.; Kohno, T.; Chen, G.; Noguchi, H.; Abe, I.

FEBS J.

274

1073-1082

682363

-

Esterification reactions in the biosynthesis of tropane alkaloids in transformed root cultures

1994

Robins, R.J.; Bachmann, P.; Peerless, A.C.J.; Rabot, S.

Plant Cell Tissue Organ Cult.

38

241-247

686918

18439860

The unprocessed preprotein form IATC103S of the isopenicillin N acyltransferase is transported inside peroxisomes and regulates its self-processing

2008

Garcia-Estrada, C.; Vaca, I.; Fierro, F.; Sjollema, K.; Veenhuis, M.; Martin, J.F.

Fungal Genet. Biol.

45

1043-1052

690642

18542924

Benzoyl-coenzyme A thioesterase of Azoarcus evansii: properties and function

2008

Ismail, W.

Arch. Microbiol.

190

451-460

690932

18247525

Divergence of function in the hot dog fold enzyme superfamily: the bacterial thioesterase YciA

2008

Zhuang, Z.; Song, F.; Zhao, H.; Li, L.; Cao, J.; Eisenstein, E.; Herzberg, O.; Dunaway-Mariano, D.

Biochemistry

47

2789-2796

707430

19405909

Thioesterase superfamily member 2 (Them2)/acyl-CoA thioesterase 13 (Acot13): a homotetrameric hotdog fold thioesterase with selectivity for long-chain fatty acyl-CoAs

2009

Wei, J.; Kang, H.W.; Cohen, D.E.

Biochem. J.

421

311-322

707446

3942600

Interaction of 2,4-dichlorophenoxyacetate (2,4-D) and 2,4,5-trichlorophenoxyacetate (2,4,5-T) with the acyl-CoA: amino acid N-acyltransferase enzymes of bovine liver mitochondria

1986

Kelley, M.; Vessey, D.A.

Biochem. Pharmacol.

35

289-295

707486

19170545

The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis

2009

Cao, J.; Xu, H.; Zhao, H.; Gong, W.; Dunaway-Mariano, D.

Biochemistry

48

1293-1304

716755

20660314

Bacterial phenylalanine and phenylacetate catabolic pathway revealed

2010

Teufel, R.; Mascaraque, V.; Ismail, W.; Voss, M.; Perera, J.; Eisenreich, W.; Haehnel, W.; Fuchs, G.

Proc. Natl. Acad. Sci. USA

107

14390-14395

717032

20823522

Crystallization and preliminary X-ray analysis of PaaAC, the main component of the hydroxylase of the Escherichia coli phenylacetyl-coenzyme A oxygenase complex

2010

Grishin, A.; Ajamian, E.; Zhang, L.; Cygler, M.

Acta Crystallogr. Sect. F

66

1045-1049

718163

22398448

An oxygenase that forms and deoxygenates toxic epoxide

2012

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Glycopeptide antibiotic biosynthesis: enzymatic assembly of the dedicated amino acid monomer (S)-3,5-dihydroxyphenylglycine

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Structural and functional characterization of the PaaI thioesterase from Streptococcus pneumoniae reveals a dual specificity for phenylacetyl-CoA and medium-chain fatty Acyl-CoAs and a novel CoA-induced fit mechanism

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Links to other databases for phenylacetyl-CoA

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