Ligand propane-1,2-diol

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Basic Ligand Information

Molecular Structure
Picture of propane-1,2-diol (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C3H8O2
propane-1,2-diol
DNIAPMSPPWPWGF-UHFFFAOYSA-N
Synonyms:
(R)[or(S)]-propane-1,2-diol, (R) [or (S)]-Propane-1,2-diol, (R)[or (S)]-propane-1,2-diol, (R,S)-1,2-propanediol, 1,2-propandiol, 1,2-propanediol, 1,2-propylene glycol, D,L-propan-1,2-diol, DL-1,2-Propanediol, DL-Propan-1,2-diol, methylglycol, Propan-1,2-diol, propane-1,2 diol, Propyleneglycol, Propylene glycol, rac-1,2-propanediol, RS-1,2-propanediol

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
1,2-propylene glycol + NAD+ = ? + NADH + H+
show the reaction diagram
-
rac-1,2-propanediol + NAD+ = hydroxyacetone + NADH + H+
show the reaction diagram
-
1,2-propanediol + O2 = ?
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-lactaldehyde + NADPH + H+ = propane-1,2-diol + NADP+
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (51 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
1,2-propanediol + NADP+ = hydroxyacetone + NADPH
show the reaction diagram
-
1,2-propanediol + NAD+ = ? + NADH + H+
show the reaction diagram
-
1,2-propanediol + NAD+ = 1-hydroxy-2-propanal + NADH
show the reaction diagram
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propane-1,2-diol + NAD+ = methylglyoxal + NADH
show the reaction diagram
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1,2-propanediol + NAD+ = ? + NADH + H+
show the reaction diagram
-
1,2-propanediol + NAD+ = ? + NADH
show the reaction diagram
-
propan-1,2-diol + NAD+ = ?
show the reaction diagram
-
1,2-propandiol + NADH + H+ = ?
show the reaction diagram
-
1,2-propanediol + NAD+ = ? + NADH
show the reaction diagram
-
1,2-propanediol + ferricytochrome c = ?
show the reaction diagram
-
1,2-propanediol + O2 = 1,2-propanedione + H2O2
show the reaction diagram
-
1,2-propanediol + O2 = ?
show the reaction diagram
-
1,2-propanediol + ferricyanide = 2-hydroxypropanal + ferrocyanide
show the reaction diagram
-
propylene glycol + acceptor = ?
show the reaction diagram
-
1,2-propanediol + NAD+ = ?
show the reaction diagram
-
di-N-acetylchitobiose + 1,2-propanediol = ?
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
hydroxyacetone + NADH + H+ = propane-1,2-diol + NAD+
show the reaction diagram
-
-
D-lactaldehyde + NADPH + H+ = propane-1,2-diol + NADP+
show the reaction diagram
-
-
acetol + NADPH = propane-1,2 diol + NADP+
show the reaction diagram
-
-
L-lactaldehyde + NADPH + H+ = propane-1,2-diol + NADP+
show the reaction diagram
-
hydroxy-2-propanone + NADH = propylene glycol + NAD+
show the reaction diagram
-
-
pyruvaldehyde + H2O = pyruvate + methylglycol
show the reaction diagram
-

Activator in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activates
-
25-40% v/v, up to 20fold increase of the activity, methoxycarbonyl-D-Nle-Gly-Arg-p-nitroanilide as substrate, rFIXa
-
activates
-

Inhibitor in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
2%, 47% inhibition
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (14 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.0433
-
-
392
-
37°C, recombinant enzyme, purification method 2

KM Value (71 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
11.5
-
pH 9.0, 60°C
38
-
-
11
-
-

References & Links

Links to other databases for propane-1,2-diol

ChEBI
PubChem
ChEBI
PubChem