Ligand 2-butanol

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

Basic Ligand Information

Molecular Structure
Picture of 2-butanol (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C4H10O
2-butanol
BTANRVKWQNVYAZ-UHFFFAOYSA-N
Synonyms:
3-butanol, butan-2-ol, sec-butanol

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2-butanol + NAD(P)+ = butan-2-one + NAD(P)H + H+
show the reaction diagram
-
butan-2-ol + NADP+ = butanone + NADPH + H+
show the reaction diagram
-
2-butanol + O2 = butan-2-one + H2O2
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (40 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2-butanol + NAD+ = ? + NADH + H+
show the reaction diagram
-
2-butanol + NADP+ = 2-butanone + NADPH + H+
show the reaction diagram
-
2-butanol + NAD+ = NADH + butanone
show the reaction diagram
-
2-butanol + NAD+ = 2-butanone + NADH
show the reaction diagram
-
2-butanol + NAD+ = 2-butanone + NADH + H+
show the reaction diagram
-
2-butanol + NAD+ = 2-butanone + NADH + H+
show the reaction diagram
-
butan-2-ol + NADP+ = butanone + NADPH + H+
show the reaction diagram
-
2-butanol + NAD+ = 2-butanone + NADH
show the reaction diagram
-
2-butanol + ferricytochrome c = 2-butanone + ferrocytochrome c + H+
show the reaction diagram
-
2-butanol + O2 = 2-butanone + H2O2
show the reaction diagram
-
2-butanol + ubiquinone = 2-butanone + ubiquinol
show the reaction diagram
-
2-butanol + pyrroloquinoline quinone = butane-2-one + reduced pyrroloquinoline quinone
show the reaction diagram
-
2-butanol + acceptor = 2-butanone + reduced acceptor
show the reaction diagram
-
2-butanol + N,N-dimethyl-4-nitrosoaniline = butanone + 4-(hydroxylamino)-N,N-dimethylaniline
show the reaction diagram
-
4-nitrophenyl sulfate + 2-butanol = 4-nitrophenol + 2-butyl sulfate
show the reaction diagram
-
isophthalate + 2-butanol = isophthalic acid mono(1-methylpropyl)ester + isophthalic acid di(1-methylpropyl)ester + H2O
show the reaction diagram
-
di-N-acetylchitobiose + 2-butanol = ?
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (27 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2-butanone + NADPH = 2-butanol + NADP+
show the reaction diagram
-
-
butan-2-one + NADPH + H+ = butan-2-ol + NADP+
show the reaction diagram
-
-
butan-2-one + NADH + H+ = butan-2-ol + NAD+
show the reaction diagram
-
-
2-butanone + reduced coenzyme F420 = 2-butanol + oxidized coenzyme F420
show the reaction diagram
-
-
butane + NADH + H+ + O2 = butan-2-ol + NAD+ + H2O
show the reaction diagram
-
-
butane + NAD(P)H + O2 = 1-butanol + 2-butanol + NAD(P)+ + H2O
show the reaction diagram
-
sec-butyl acetate + H2O = sec-butanol + acetate
show the reaction diagram
-
-
2-butyl ferulate + H2O = ferulic acid + 2-butanol
show the reaction diagram
-
-

Activator in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activates
-
2-butanol enhances lipase activity
-
3fold activation
-
isoform AC6 shows about 60% stimulation of activity with 100 mM 2-butanol, isoform AC7 shows about 70% stimulation of activity with 100 mM 2-butanol, isoform AC9 shows about 60% stimulation of activity with 100 mM 2-butanol
-

Inhibitor in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
substrate inhibition
-
10% (v/v), 52% inhibition; 10% (w/v), 42% inhibition
-
highest decrease of activity in comparison to ethanol and 2-propanol
-

3D Structure of Enzyme-Ligand-Complex (PDB) (2 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (8 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
149
-
pH 7.5, 37°C
833
-
cosubstrate: NADP+, pH 7.5, 80°C
49
-
pH 5.8, 37°C

KM Value (24 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
3.5
-
pH 7.5, 37°C
0.3
-
pH and temperature not specified in the publication
0.00078
-
37°C, pH 9.0
0.065
-
pH 8.5, 30°C
0.662
-
at pH 7.0 and 30°C
1.2
-
pH 5.8, 37°C
10.1
-
pH 7.0, 45°C

Ki Value (4 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
4.4
-
pH 7.0, 45°C
11700
-
pH 7.5, 25°C

References & Links

Links to other databases for 2-butanol

ChEBI
PubChem
-
PubChem