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Ligand 4-hydroxy-N-alpha-acetyl-L-arginine

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

Product in Enzyme-catalyzed Reactions (1 result)

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Show Product (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.11.21

N-alpha-acetyl-L-arginine + 2-oxoglutarate + O2 = 4-hydroxy-N-alpha-acetyl-L-arginine + succinate + CO2 + H2O

639273, 639277, 639283, 639281, 639286

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Enzyme Kinetic Parameters

References & Links

Literature References (5)

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Show Reference (5 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

639273

8229018

Synthesis and reaction of potential alternate substrates and mechanism-based inhibitors of clavaminate synthase

1993

Iwata-Reuyl, D.; Basak, A.; Silverman, L.S.; Engle, C.A.; Townsend, C.A.

J. Nat. Prod.

56

1373-1396

639277

8831977

A single monomeric iron center in clavaminate synthase catalyzes three nonsuccessive oxidative transformations

1996

Busby, R.W.; Townsend, C.A.

Bioorg. Med. Chem.

4

1059-1064

639281

10655615

Structural origins of the selectivity of the trifunctional oxygenase clavaminic acid synthase

2000

Zhang, Z.; Ren, J.; Stammers, D.K.; Baldwin, J.E.; Harlos, K.; Schofield, C.J.

Nat. Struct. Biol.

7

127-133

639283

11112446

Mutagenesis studies on the iron binding ligands of clavaminic acid synthase

2000

Doan, L.X.; Hassan, A.; Lipscomb, S.J.; Dhanda, A.; Zhang, Z.; Schofield, C.J.

Biochem. Biophys. Res. Commun.

279

240-244

639286

12062399

Crystal structure of a clavaminate synthase-Fe(II)-2-oxoglutarate-substrate-NO complex: evidence for metal centred rearrangements

2002

Zhang, Z.; Ren, J.s.; Harlos, K.; McKinnon, C.H.; Clifton, I.J.; Schofield, C.J.

FEBS Lett.

517

7-12

Links to other databases for 4-hydroxy-N-alpha-acetyl-L-arginine

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Show Links (1 entry)

ChEBI

PubChem

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