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Ligand ADP-glucose

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Basic Ligand Information

Molecular Structure
Picture of ADP-glucose (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
Molfile
C16H25N5O15P2
ADP-glucose
WFPZSXYXPSUOPY-ROYWQJLOSA-N
Synonyms:
ADP-alpha-D-glucose, ADP-D-glucose, ADP-Glc, ADPglucose

Related pathways

Pathway Source
Pathways
MetaCyc
glucosylglycerate biosynthesis II, glucosylglycerol biosynthesis, glycogen biosynthesis I (from ADP-D-Glucose), glycogen biosynthesis III (from alpha-maltose 1-phosphate), mannosylglucosylglycerate biosynthesis II more


Show all pahtways known for Show all BRENDA pathways known for ADP-glucose

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (18 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ADP-glucose + protein = ADP + alpha-D-glucosyl-protein
show the reaction diagram
-
ADP-glucose + D-fructose = ADP + sucrose
show the reaction diagram
-
ADP-alpha-D-glucose + D-glucose 6-phosphate = ADP + alpha,alpha-trehalose 6-phosphate
show the reaction diagram
-
ADP-alpha-D-glucose + D-glucose = ADP + alpha,alpha-trehalose
show the reaction diagram
-
ADP-alpha-D-glucose + alpha-D-glucose-1-phosphate = ADP + alpha-maltose-1-phosphate
show the reaction diagram
-
ADP-alpha-D-glucose + D-glucose 6-phosphate = ADP + alpha,alpha-trehalose 6-phosphate
show the reaction diagram
-
ADP-glucose + H2O = AMP + alpha-D-glucose 1-phosphate
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ADP + sucrose = ADP-glucose + D-fructose
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (84 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ADP-glucose + protein = ADP + alpha-D-glucosyl-protein
show the reaction diagram
-
ADP-glucose + D-fructose 6-phosphate = ADP + sucrose 6-phosphate
show the reaction diagram
-
ADP-glucose + indoxyl = ADP + indican
show the reaction diagram
-
ADP-alpha-D-glucose + validoxylamine A = ADP + validamycin A
show the reaction diagram
-
ADP-alpha-D-glucose + alpha-D-glucose-1-phosphate = ADP + alpha-maltose-1-phosphate
show the reaction diagram
-
ADP-alpha-D-glucose + D-glucose 6-phosphate = ADP + alpha,alpha-trehalose 6-phosphate
show the reaction diagram
-
ADP-glucose + p-nitrophenol = ADP + p-nitrophenyl beta-D-glucoside
show the reaction diagram
-
ADP-glucose + glucose 6-phosphate = ADP + alpha,alpha-trehalose 6-phosphate
show the reaction diagram
-
ADP-alpha-D-glucose + 3-hydroxyflavone = ADP + 3-hydroxyflavone 3-O-beta-D-glucoside
show the reaction diagram
-
ADP-glucose + 7,8-dihydroxyflavone = ADP + 7-O-beta-D-glucosyl-7,8-dihydroxyflavone
show the reaction diagram
-
diphosphate + ADP-glucose = ATP + alpha-D-glucose 1-phosphate
show the reaction diagram
ADP-alpha-D-glucose + phosphate = ADP + alpha-D-glucose 1-phosphate
show the reaction diagram
-
ADP-alpha-D-glucose + phosphate = alpha-D-glucose 1-phosphate + ADP
show the reaction diagram
-
ADP-glucose + H2O = ?
show the reaction diagram
-
ADP-glucose + H2O = IDP-glucose + NH3
show the reaction diagram
-
ADP-glucose + H2O = ?
show the reaction diagram
-
ADP-glucose + H2O = AMP + alpha-D-glucose 1-phosphate
show the reaction diagram
-
ADP-glucose + H2O = ?
show the reaction diagram
-
ADP-D-glucose = ?
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (13 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Activator in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
170% activation of glycogen synthesis in the absence of AMP and NaF, 68% inhibition in the presence of AMP and NaF
-
10 mM, activates
-
2 mM, 2.1% stimulation
-
activates 4.5% at 5 mM
-
5 mM, slight activation
-

Inhibitor in Enzyme-catalyzed Reactions (27 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive with UDPglucose
-
strong
-
competitive against UDP-N-acetyl-D-glucosamine
-
weak
-
weak
-
competitive
-
0.5 mM, 77.8% of initial activity
-

3D Structure of Enzyme-Ligand-Complex (PDB) (4 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (22 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
29
-
pH and temperature not specified in the publication
139
-
37°C, wild-type large subunit
9.1
-
25°C, pH 7.6, wild-type enzyme

KM Value (134 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.9
-
-
0.48
-
pH 8.0, 30°C
0.6
-
37°C, pH 5.5
0.44
-
pH and temperature not specified in the publication
3.16
-
25°C, pH 7.6, wild-type enzyme

Ki Value (24 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
22
-
-
0.75
-
recombinant enzyme

References & Links

Links to other databases for ADP-glucose

EXTERNAL LINKS