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BRENDA support

Ligand 3'-phospho-5'-adenylyl sulfate

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Basic Ligand Information

Molecular Structure
Picture of 3'-phospho-5'-adenylyl sulfate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
Molfile
C10H15N5O13P2S
3'-phospho-5'-adenylyl sulfate
GACDQMDRPRGCTN-KQYNXXCUSA-N
Synonyms:
3'-phopshoadenylyl sulfate, 3'-phosphoadenosine-5'-phosphosulfate, 3'-phosphoadenosine 5'-phosphosulfate, 3'-phosphoadenylyl-sulfate, 3'-phosphoadenylyl 5'-phosphosulfate, 3'-phosphoadenylyl sulfate, 3'-phosphoadenylylsulfate, 3'-phosphoadenylysulfate, 3-phospho-5-adenylyl sulfate, 3-phosphoadenylylsulfate, 3-phosphoadenylyl sulfate, 5'-O-[hydroxy(sulfooxy)phosphoryl]adenosine 3'-(dihydrogen phosphate), adenosine 3',5'-bisphosphate sulfate, adenosine 3'-phosphate 5'-phosphosulfate, PAPS, phosphoadenosine-5'-phosphosulfate

Related pathways

Pathway Source
Pathways
MetaCyc
ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide, assimilatory sulfate reduction I, assimilatory sulfate reduction IV, brassinosteroids inactivation, chondroitin sulfate biosynthesis more


Show all pahtways known for Show all BRENDA pathways known for 3'-phospho-5'-adenylyl sulfate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (287 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
3'-phosphoadenylylsulfate + galactosylsphingosine = adenosine 3',5'-bisphosphate + psychosine sulfate
show the reaction diagram
-
3'-phosphoadenylylsulfate + a thiol = adenosine 3',5'-bisphosphate + an S-alkyl thiosulfate
show the reaction diagram
-
3'-phosphoadenylylsulfate + cortisol = adenosine 3',5'-bisphosphate + cortisol 21-sulfate
show the reaction diagram
-
3'-phosphoadenylylsulfate + alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,3-1-O-alkyl-2-O-acylglycerol = adenosine 3',5'-bisphosphate + 6-sulfo-alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,3-1-O-alkyl-2-O-acylglycerol
show the reaction diagram
-
3'-phosphoadenylylsulfate + desulfobenzylglucosinolate = adenosine 3',5'-bisphosphate + benzylglucosinolate
show the reaction diagram
-
3'-phosphoadenylylsulfate + quercetin = adenosine 3',5'-bisphosphate + quercetin 3-sulfate
show the reaction diagram
-
3'-phosphoadenylylsulfate + quercetin 3-sulfate = adenosine 3',5'-bisphosphate + quercetin 3,3'-bissulfate
show the reaction diagram
-
3'-phosphoadenylylsulfate + quercetin 3-sulfate = quercetin 3,4'-disulfate + adenosine 3',5'-bisphosphate
show the reaction diagram
-
3'-phosphoadenylyl sulfate + desulfo-A47934 = adenosine 3',5'-bisphosphate + A47934
show the reaction diagram
-
3'-phosphoadenylyl sulfate + alpha,alpha-trehalose = adenosine 3',5'-bisphosphate + 2-O-sulfo-alpha,alpha-trehalose
show the reaction diagram
-
3'-phosphoadenylyl sulfate + desulfosinigrin = adenosine 3',5'-bisphosphate + sinigrin
show the reaction diagram
-
3'-phosphoadenylylsulfate + choline = adenosine 3',5'-bisphosphate + choline sulfate
show the reaction diagram
-
3'-phosphoadenylylsulfate + UDP-N-acetylgalactosamine 4-sulfate = adenosine 3',5'-bisphosphate + UDP-N-acetylgalactosamine-4,6-bissulfate
show the reaction diagram
-
3'-phosphoadenylyl sulfate + [heparan sulfate]-iduronate = adenosine 3',5'-bisphosphate + [heparan sulfate]-iduronate 2-sulfate
show the reaction diagram
-
3'-phosphoadenylylsulfate + H2O = adenosine 3',5'-bisphosphate + SO42-
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
adenosine 3',5'-bisphosphate + dopamine sulfate = 3'-phosphoadenylyl sulfate + dopamine
show the reaction diagram
-
-
adenosine 3',5'-bisphosphate + Cypridina luciferyl sulfate = 3'-phosphoadenylyl sulfate + Cypridina luciferin
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (1395 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
3'-phosphoadenosine-5'-phosphosulfate + thioredoxin = ? + thioredoxin disulfide
show the reaction diagram
-
3'-phosphoadenylylsulfate + galactosylsphingosine = adenosine 3',5'-bisphosphate + psychosine sulfate
show the reaction diagram
-
3'-phosphoadenylyl-sulfate + 12-hydroxyjasmonate = adenosine 3',5'-bisphosphate + 12-sulfooxyjasmonate
show the reaction diagram
-
3'-phosphoadenylyl sulfate + dihydromenaquinone-9 = adenosine 3',5'-bisphosphate + S881
show the reaction diagram
-
3'-phosphoadenylyl sulfate + [heparan sulfate]-iduronate = adenosine 3',5'-bisphosphate + [heparan sulfate]-iduronate 2-sulfate
show the reaction diagram
-
3'-phosphoadenosine 5'-phosphosulfate + H2O = ?
show the reaction diagram
-
3'-phosphoadenylylsulfate + H2O = adenosine 3',5'-bisphosphate + SO42-
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (30 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
MgATP2- + adenylyl sulfate = MgADP- + 3-phosphoadenylyl sulfate
show the reaction diagram
-
adenosine 3',5'-bisphosphate + desulfated chondroitin sulfate = 3'-phosphoadenylyl sulfate + desulfated chondroitin
show the reaction diagram
-
-
adenosine 3',5'-bisphosphate + Cypridina luciferyl sulfate = 3'-phosphoadenylyl sulfate + Cypridina luciferin
show the reaction diagram
-
-

Enzyme Cofactor/Cosubstrate (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

Activator in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activation, can replace ADP to some extent
-
choline sulfate formation is increased 5fold by 1.0 mM
-

Inhibitor in Enzyme-catalyzed Reactions (13 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
substrate inhibition
-
inhibition above 0.33 mM
-
substrate inhibition of SULT2A1, structure analysis of SULT2A1/DHEA and SULT2A1/PAP or SULT2A1/ADT, overview
-

3D Structure of Enzyme-Ligand-Complex (PDB) (90 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (21 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
1.6
-
pH 7.5, 22°C

KM Value (177 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.00058
-
pH 6.4, 37°C
0.01
-
wild type
0.00035
-
-
0.0025
-
22°C, pH 8.0
0.0005
-
pH 6.8, 25°C
0.018
-
pH 7.5, 22°C
0.001
-
pH 7.5, 25°C
-999
-
KM value lower than 0.01 mM

Ki Value (12 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.00035
-
P-PST, pH 8.5

References & Links

Links to other databases for 3'-phospho-5'-adenylyl sulfate

EXTERNAL LINKS