Ligand coptisine

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Basic Ligand Information

Molecular Structure
Picture of coptisine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C19H15ClNO4
coptisine
LUXPUVKJHVUJAV-UHFFFAOYSA-M
Pathway Source
Pathways

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
coptisine + NADPH = ? + NADP+
show the reaction diagram
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S-adenosyl-L-methionine + coptisine + NADPH + H+ = S-adenosyl-L-homocysteine + tetrahydrocorysamine + NADP+
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
coptisine can bind to the active pocket of SrtB, residues Arg115, Asn116, and Ile182 play a vital role in the interaction of SrtB with coptisine. Coptisine can reduce the adhesion of Staphylococcus aureus to human lung epithelial cells
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natural protoberberine alkaloid
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Enzyme Kinetic Parameters

IC50 Value (4 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.0251
-
in 50 mM sodium acetate buffer (pH 5.0), at 22°C
-999
-
IC50 value is 0.0087 mg/ml

References & Links

Links to other databases for coptisine

ChEBI
PubChem
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PubChem