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• Roles as Enzyme Ligand
• • In Vivo Substrate
  • In Vivo Product
  • Substrate
  • Product
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  • Activator
  • Inhibitor
  • Metals and Ions
  • 3D Structure (PDB)
• Enzyme Kinetic Parameters
• • k_cat Value (Turnover Number)
  • K_M Value
  • K_i Value
  • IC₅₀ Value
• References & Links
• • References
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Ligand baccatin III

Basic Ligand Information

Molecular Structure

Show all BRENDA pathways known for baccatin III

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Natural Substrate (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.B16

baccatin III + 3-amino-3-phenylpropanoyl-CoA = 3'-N-debenzoyl-2'-deoxytaxol + coenzyme A

716800

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In Vivo Product in Enzyme-catalyzed Reactions (1 result)

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Show Natural Product (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.167

acetyl-CoA + 10-deacetylbaccatin III = CoA + baccatin III

, 486453, 486455

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Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Substrate (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.B16

baccatin III + 3-amino-3-phenylpropanoyl-CoA = 3'-N-debenzoyl-2'-deoxytaxol + coenzyme A

716800

-

2.3.1.B16

baccatin III + 3-phenylisoserinoyl-CoA = ? + coenzyme A

716800

-

2.3.1.B16

2 entries

Product in Enzyme-catalyzed Reactions (4 results)

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Show Product (4 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.167

acetyl-CoA + 10-deacetylbaccatin III = CoA + baccatin III

, 486453, 486455

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2.3.1.167

acetyl-CoA + 4-deacetylbaccatin III = CoA + baccatin III

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2.3.1.167

N-acetyl-D-glucosamine + 10-deacetylbaccatin III = D-glucosamine + baccatin III

-

-

2.3.1.167

vinyl acetate + 10-deacetylbaccatin III = vinyl alcohol + baccatin III

-

-

2.3.1.167

4 entries

Enzyme Kinetic Parameters

K_M Value (1 result)

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Show KM Value (1 entry)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.3.1.B16

0.0024

-

pH and temperature not specified in the publication

716800

References & Links

Literature References (3)

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Show Reference (3 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

486453

10639122

Molecular cloning of a 10-deacetylbaccatin III-10-O-acetyl transferase cDNA from Taxus and functional expression in Escherichia coli

2000

Walker.K.; Croteau, R.

Proc. Natl. Acad. Sci. USA

97

583-587

486455

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Acetyl CoA: 10-deacetylbaccatin-III-10-O-acetyltransferase activity in leaves and cell suspension cultures of Taxus cuspidata

1998

Pennington, J.J.; Fett-Neto, A.G.; Nicholson, S.A.; Kingston, D.G.I.; Dicosmo, F.

Phytochemistry

49

2261-2266

716800

12232048

Molecular cloning and heterologous expression of the C-13 phenylpropanoid side chain-CoA acyltransferase that functions in Taxol biosynthesis

2002

Walker, K.; Fujisaki, S.; Long, R.; Croteau, R.

Proc. Natl. Acad. Sci. USA

99

12715-12720

Links to other databases for baccatin III

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Show Links (1 entry)

ChEBI

PubChem

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