Ligand protoporphyrinogen

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Basic Ligand Information

Molecular Structure
Picture of protoporphyrinogen (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C34H40N4O4
protoporphyrinogen
UHSGPDMIQQYNAX-UHFFFAOYSA-N
Synonyms:
protoporphyrinogen-IX, protoporphyrinogen IX


Show all pahtways known for Show all BRENDA pathways known for protoporphyrinogen

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (11 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
protoporphyrinogen IX + O2 = protoporphyrin IX + H2O
show the reaction diagram
-
protoporphyrinogen + glutathione = protoporphyrinogen-S-glutathione + H2O
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (13 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (14 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
protoporphyrinogen IX + O2 = protoporphyrin IX + H2O
show the reaction diagram
-
protoporphyrinogen + glutathione = protoporphyrinogen-S-glutathione + H2O
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (20 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
acts as a competitive inhibitor of the coproporphyrinogen III to coproporphyrin oxidase activity of HemY
-
substrate inhibition above 0.05 mM
-
inhibits both erythroid and lymphoblast forms of the enzyme
-
feedback inhibition by downstream intermediate
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (74 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.44
-
at pH 8.0 and 37°C
0.292
-
pH 8.0, 37°C

KM Value (85 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.001
-
at pH 8.7 and 37°C
0.007
-
pH 8.0, 37°C

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0003
-
at pH 7.2 and 30°C

References & Links

Links to other databases for protoporphyrinogen

ChEBI
PubChem
ChEBI
PubChem