Ligand methyl-cob(III)alamin

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Basic Ligand Information

Molecular Structure
Picture of methyl-cob(III)alamin (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C63H93CoN13O14P
methyl-cob(III)alamin
UKAOQJHGJIMJQJ-IOYQEBOVSA-M
Synonyms:
methylcob(III)-amide, methylcob(III)alamin

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
S-adenosyl-L-methionine + methylcob(III)alamin + 2-hydroxyethylphosphonate = 5'-deoxyadenosine + L-methionine + cob(III)alamin + (2S)-2-hydroxypropylphosphonate
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
S-adenosyl-L-methionine + methylcob(III)alamin + 2-hydroxyethylphosphonate = 5'-deoxyadenosine + L-methionine + cob(III)alamin + (2S)-2-hydroxypropylphosphonate
show the reaction diagram
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5,6,7,8-tetrahydromethanopterin + methylcob(III)alamin = 5-methyl-5,6,7,8-tetrahydromethanopterin + cob(III)alamin
show the reaction diagram
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mercaptopropionate + methylcob(III)alamin = ?
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
glycine betaine + cob(I)alamin = dimethylglycine + methylcob(III)alamin
show the reaction diagram
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Enzyme Cofactor/Cosubstrate (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
the addition of 0.05 mM methylcob(III)alamin to the crude extract results in an about 6fold increase in activity which is not greatly affected by the addition of cytochrome P450 reductase or reductase domain of neuronal nitric oxide synthase
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Inhibitor in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
product inhibition
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.315
-
at pH 7.2, temperature not specified in the publication

KM Value (1 result)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0122
-
at pH 7.2, temperature not specified in the publication

References & Links

Links to other databases for methyl-cob(III)alamin

ChEBI
PubChem
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PubChem