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Ligand 1,4-diguanidinobutane

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Natural Substrate (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.5.3.20

1,4-diguanidinobutane + H2O = agmatine + urea

209443, 209444

-

Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Substrate (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.5.3.20

1,4-diguanidinobutane + H2O = agmatine + urea

209443, 209444

-

Inhibitor in Enzyme-catalyzed Reactions (4 results)

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Show Inhibitors (4 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

3.5.3.12

agmatine analogue, strong competitive inhibition

657259

-

3.5.3.12

competitive inhibitor

670510, 674316

-

3.5.3.12

2 entries

3.5.3.6

-

209453

-

4.1.1.19

-

4083

-

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (1 result)

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Show Turnover Number (1 entry)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

3.5.3.20

1330

-

per subunit

209444

K_M Value (2 results)

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Show KM Value (2 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

3.5.3.20

0.65

-

-

209444

3.5.3.20

0.7

-

-

209443

3.5.3.20

2 entries

K_i Value (3 results)

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Show KI Value (3 entries)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

3.5.3.12

0.0033

-

-

670510

3.5.3.12

0.0071

-

pH 7.0, 30°C

657259

3.5.3.12

0.028

-

at 37°C

674316

3.5.3.12

3 entries

References & Links

Literature References (7)

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Show Reference (7 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

4083

1252

Arginine decarboxylase from Lathyrus sativus seedlings. Purification and properties

1975

Ramakrishna, S.; Adiga, P.R.

Eur. J. Biochem.

59

377-386

209443

-

Degradation of alpha,omega-diguanidinoalkanoates and a novel enzyme, diguanidinobutane amidohydrolase in Pseudomonas putida

1989

Yorifuji, T.; Kaneoke, M.; Shimizu, E.; Shiota, K.; Matsuo, R.

Agric. Biol. Chem.

53

3003-3009

209444

-

Diguanidinobutanase of Pseudomonas putida and enzymatic preparation of agmatine from 1,4-diguanidinobutanate

1995

Shoeb, S.M.; Kaneoke, M.; Shimizu, E.; Yorifuji, T.

Appl. Microbiol. Biotechnol.

44

94-99

209453

681336

Arginine deiminase from Mycoplasma arthritidis. Structure-activity relationships among substrates and competitive inhibitors

1978

Smith, D.W.; Ganaway, R.L.; Fahrney, D.E.

J. Biol. Chem.

253

6016-6020

657259

12821325

Agmatine deiminase from cucumber seedlings is a mono-specific enzyme: purification and characteristics

2003

Sakakibara, Y.; Yanagisawa, H.

Protein Expr. Purif.

30

88-93

670510

11314948

Agmatine deiminase from maize shoots: purification and properties

2001

Yanagisawa, H.

Phytochemistry

56

643-647

674316

17028272

The gene cluster for agmatine catabolism of Enterococcus faecalis: study of recombinant putrescine transcarbamylase and agmatine deiminase and a snapshot of agmatine deiminase catalyzing its reaction

2007

Llacer, J.L.; Polo, L.M.; Tavarez, S.; Alarcon, B.; Hilario, R.; Rubio, V.

J. Bacteriol.

189

1254-1265

Links to other databases for 1,4-diguanidinobutane

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Show Links (1 entry)

ChEBI

PubChem